Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients - Hitomi, Toshiaki; Habu, Toshiyuki; Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H.; Osafune, Kenji; Taura, Daisuke; Sone, Masakatsu; Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; et al. (Biochemical and biophysical research communications, 2013)
Keywords: 60 APPLIED LIFE SCIENCES; Adenosine Triphosphatases; alleles; ANGIOGENESIS; CARRIERS; Cells, Cultured; Child; DISEASES; Down-Regulation; endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; ENDOTHELIUM; Female; FIBROBLASTS; gene expression; GENES; Humans; IN VITRO; induced pluripotent stem cells; INHIBITION; iPS cells; Male; Middle Aged; MITOSIS; Moyamoya disease; Moyamoya Disease - metabolism; Moyamoya Disease - pathology; Mutation - genetics; Neoplasm Proteins - metabolism; Neovascularization, Pathologic - pathology; Neovascularization, Pathologic - physiopathology; PATIENTS; Pluripotent Stem Cells - metabolism; Pluripotent Stem Cells - pathology; RNA; RNA interference; RNF213; Securin; STEM CELLS; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; VEINS; Angiogenesis; Moyamoya disease; RNF213; Securin; iPS cells; Endothelium