Pseudomonas aeruginosa Regulates Flagellin Expression as Part of a Global Response to Airway Fluid from Cystic Fibrosis Patients

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 101; no. 17; pp. 6664 - 6668
• Main Authors: Wolfgang, Matthew C., Jyot, Jeevan, Goodman, Andrew L., Ramphal, Reuben, Lory, Stephen, Tiedje, James M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.04.2004; National Acad Sciences
• Subjects: ATP binding cassette transporters; Bacteria; Biological Sciences; Cystic fibrosis; Cystic Fibrosis - complications; Cystic Fibrosis - microbiology; Cystic Fibrosis - physiopathology; Flagellin - genetics; Fluids; Gene expression; Gene Expression Profiling; Genes; Humans; Infections; Liquids; Lungs; Microbiology; Microscopy, Electron; Mucus; Nucleic Acid Hybridization; Patients; Pattern recognition; Pseudomonas aeruginosa; Pseudomonas aeruginosa - physiology; Pseudomonas aeruginosa - ultrastructure; Pseudomonas Infections - complications; Pseudomonas Infections - physiopathology; Repression; Responses; Reverse Transcriptase Polymerase Chain Reaction; Sensors; Trachea - physiopathology

Cystic fibrosis (CF) patients are highly susceptible to chronic lung infections by the environmental bacterium Pseudomonas aeruginosa. The overproduction and accumulation of dehydrated viscous respiratory mucus and excessive inflammation represents a defining feature of CF and constitutes the major...