Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 19; no. 10; pp. 2611 - 2622
• Main Authors: BIANCO-MIOTTO, Tina, CHIAM, Karen, HORVATH, Lisa G, KENCH, James G, STRICKER, Phillip D, MARSHALL, Villis R, SUTHERLAND, Robert L, HENSHALL, Susan M, GERALD, William L, SCHER, Howard I, RISBRIDGER, Gail P, CLEMENTS, Judith A, BUCHANAN, Grant, BUTLER, Lisa M, TILLEY, Wayne D, HORSFALL, David J, RICCIARDELLI, Carmela, JINDAL, Shalini, DAY, Tanya K, THOMAS, Mervyn, PICKERING, Marie A, O'LOUGHLIN, Melissa A, RYAN, Natalie K, RAYMOND, Wendy A
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.10.2010
• Subjects: Acetylation; Biological and medical sciences; Cohort Studies; Disease Progression; Disease-Free Survival; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones - genetics; Histones - metabolism; Humans; Male; Medical sciences; Microarray Analysis; Nephrology. Urinary tract diseases; Prognosis; Prostate-Specific Antigen - blood; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Modification; Urinary system disease; Prostate disease; Prediction; Malignant tumor; Carcinogenesis; Gene expression profile; Cancerology; Tumor progression; Epigenetics; Predictive factor; Histone; Male genital diseases; Prostate cancer; Cancer

Epigenetic alterations are common in prostate cancer, yet how these modifications contribute to carcinogenesis is poorly understood. We investigated whether specific histone modifications are prognostic for prostate cancer relapse, and whether the expression of epigenetic genes is altered in prostat...