Arterial Spin Labeling Characterization of Cerebral Perfusion during Normal Maturation from Late Childhood into Adulthood: Normal ‘Reference Range’ Values and Their Use in Clinical Studies
The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics...
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| Published in | Journal of cerebral blood flow and metabolism Vol. 34; no. 5; pp. 776 - 784 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London, England
SAGE Publications
01.05.2014
Sage Publications Ltd Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0271-678X 1559-7016 1559-7016 |
| DOI | 10.1038/jcbfm.2014.17 |
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| Abstract | The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T1) and equilibrium longitudinal magnetization (M0). We present mean and reference ranges for normal values of T1, M0, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T1 relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M0 anteriorly, but posteriorly, males but not females showed a significant decline in M0 with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge–Weber syndrome and sickle cell anemia, are illustrated. |
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| AbstractList | The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T₁) and equilibrium longitudinal magnetization (M₀). We present mean and reference ranges for normal values of T₁, M₀, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T₁ relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M₀ anteriorly, but posteriorly, males but not females showed a significant decline in M₀ with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated.The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T₁) and equilibrium longitudinal magnetization (M₀). We present mean and reference ranges for normal values of T₁, M₀, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T₁ relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M₀ anteriorly, but posteriorly, males but not females showed a significant decline in M₀ with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated. The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T1) and equilibrium longitudinal magnetization (M0). We present mean and reference ranges for normal values of T1, M0, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T1 relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M0 anteriorly, but posteriorly, males but not females showed a significant decline in M0 with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge–Weber syndrome and sickle cell anemia, are illustrated. The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T₁) and equilibrium longitudinal magnetization (M₀). We present mean and reference ranges for normal values of T₁, M₀, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T₁ relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M₀ anteriorly, but posteriorly, males but not females showed a significant decline in M₀ with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated. The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time ( T 1 ) and equilibrium longitudinal magnetization ( M 0 ). We present mean and reference ranges for normal values of T 1 , M 0 , cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T 1 relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M 0 anteriorly, but posteriorly, males but not females showed a significant decline in M 0 with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge–Weber syndrome and sickle cell anemia, are illustrated. The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time ( T 1 ) and equilibrium longitudinal magnetization ( M 0 ). We present mean and reference ranges for normal values of T 1 , M 0 , cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T 1 relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M 0 anteriorly, but posteriorly, males but not females showed a significant decline in M 0 with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge–Weber syndrome and sickle cell anemia, are illustrated. The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T) and equilibrium longitudinal magnetization (M). We present mean and reference ranges for normal values of T, M, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M anteriorly, but posteriorly, males but not females showed a significant decline in M with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated. The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T sub(1)) and equilibrium longitudinal magnetization (M sub(0)). We present mean and reference ranges for normal values of T sub(1), M sub(0), cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T sub(1) relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M sub(0) anteriorly, but posteriorly, males but not females showed a significant decline in M sub(0) with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated. |
| Author | Hales, Patrick W Kawadler, Jamie M Aylett, Sarah E Clark, Christopher A Kirkham, Fenella J |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24496173$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1073/pnas.0402680101 10.1016/S0301-5629(02)00705-6 10.1073/pnas.1006025107 10.1186/1532-429X-15-13 10.1002/jmri.20839 10.1148/radiol.12111509 10.1038/jcbfm.2009.6 10.1002/mrm.22484 10.1002/(SICI)1522-2594(199906)41:6<1246::AID-MRM22>3.0.CO;2-N 10.1002/sim.4780100502 10.1016/j.ejrad.2008.02.011 10.1002/mrm.20580 10.1002/jmri.10372 10.1148/radiol.2272020903 10.1016/S0730-725X(02)00635-5 10.1002/hbm.21163 10.1136/adc.48.10.757 10.1007/s10334-012-0308-9 10.1002/ana.97 10.1002/mrm.1910360208 10.1002/mrm.1910230106 10.1542/peds.113.6.1642 10.1002/mrm.21654 10.1212/WNL.50.6.1699 10.1093/brain/113.1.27 10.1016/j.clinimag.2011.11.003 10.1109/TMI.2006.886807 10.1002/mrm.1910400308 10.1016/S0730-725X(98)00204-5 10.1177/08830738030180080701 10.1002/(SICI)1099-1492(199706/08)10:4/5<237::AID-NBM475>3.0.CO;2-X 10.1542/peds.2005-1815 10.1002/mrm.20023 10.1073/pnas.89.1.212 10.1161/01.STR.24.9.1305 10.1177/088307389701200313 10.1038/jcbfm.1985.9 10.1097/00004647-199611000-00028 10.1111/j.1471-4159.1977.tb10649.x |
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| References | Chen, Chiu, Wu, Wu, Lin, Wu 2012; 36 Wong, Buxton, Frank 1997; 10 Golay, Guenther 2012; 25 Wintermark, Lepori, Cotting, Roulet, van Melle, Meuli 2004; 113 Prohovnik, Hurlet-Jensen, Adams, De Vivo, Pavlakis 2009; 29 Sokoloff, Reivich, Kennedy, Rosiers, Patlak, Pettigrew 1977; 28 Detre, Leigh, Williams, Koretsky 1992; 23 Piechnik, Ferreira, Lewandowski, Ntusi, Banerjee, Holloway 2013; 15 Royston 1991; 10 Raznahan, Lee, Stidd, Long, Greenstein, Clasen 2010; 107 Parkes, Rashid, Chard, Tofts 2004; 51 Wang, Licht, Jahng, Liu, Rubin, Haselgrove 2003; 18 Leenders, Perani, Lammertsma, Heather, Buckingham, Jones 1990; 113 Ye, Pekar, Jezzard, Duyn, Frank, McLaughlin 1996; 36 Gogtay, Giedd, Lusk, Hayashi, Greenstein, Vaituzis 2004; 101 Broome 2008; 66 Tatu, Moulin, Bogousslavsky, Duvernoy 1998; 50 Taki, Hashizume, Sassa, Takeuchi, Wu, Asano 2011; 32 Steen, Langston, Ogg, Xiong, Ye, Wang 1999; 17 Steen, Schroeder 2003; 21 Evans, Widjaja, Connolly, Griffiths 2006; 117 Zoccoli, Lucchi, Andreoli, Bach, Cianci, Lenzi 1996; 16 Luh, Wong, Bandettini, Hyde 1999; 41 Biagi, Abbruzzese, Bianchi, Alsop, Del Guerra, Tosetti 2007; 25 Herscovitch, Raichle 1985; 5 Gunther, Oshio, Feinberg 2005; 54 Reid, Maria, Drane, Quisling, Hoang 1997; 12 Wu, Jain, Li, Giannetta, Hurt, Wehrli 2010; 64 Chiron, Raynaud, Maziere, Zilbovicius, Laflamme, Masure 1992; 33 Gallichan, Jezzard 2008; 60 Williams, Detre, Leigh, Koretsky 1992; 89 Schöning, Staab, Walter, Niemann 1993; 24 Dobbing, Sands 1973; 48 Wu, Mazaheri, Wong 2007; 26 Comi 2003; 18 Buxton, Frank, Wong, Siewert, Warach, Edelman 1998; 40 Oguz, Golay, Pizzini, Freer, Winrow, Ichord 2003; 227 Kirkham, Calamante, Bynevelt, Gadian, Evans, Cox 2001; 49 Jain, Duda, Avants, Giannetta, Xie, Roberts 2012; 263 Tortoli, Michelassi, Bambi, Guidi, Righi 2003; 29 bibr38-jcbfm.2014.17 bibr9-jcbfm.2014.17 bibr17-jcbfm.2014.17 bibr25-jcbfm.2014.17 Chiron C (bibr26-jcbfm.2014.17) 1992; 33 bibr33-jcbfm.2014.17 bibr4-jcbfm.2014.17 bibr20-jcbfm.2014.17 bibr2-jcbfm.2014.17 bibr23-jcbfm.2014.17 bibr15-jcbfm.2014.17 bibr36-jcbfm.2014.17 bibr22-jcbfm.2014.17 bibr28-jcbfm.2014.17 bibr30-jcbfm.2014.17 bibr13-jcbfm.2014.17 bibr34-jcbfm.2014.17 bibr7-jcbfm.2014.17 bibr5-jcbfm.2014.17 bibr11-jcbfm.2014.17 bibr32-jcbfm.2014.17 bibr3-jcbfm.2014.17 bibr18-jcbfm.2014.17 bibr39-jcbfm.2014.17 bibr8-jcbfm.2014.17 bibr24-jcbfm.2014.17 bibr40-jcbfm.2014.17 bibr29-jcbfm.2014.17 bibr37-jcbfm.2014.17 bibr21-jcbfm.2014.17 bibr1-jcbfm.2014.17 bibr16-jcbfm.2014.17 bibr6-jcbfm.2014.17 bibr35-jcbfm.2014.17 bibr14-jcbfm.2014.17 bibr10-jcbfm.2014.17 bibr19-jcbfm.2014.17 bibr31-jcbfm.2014.17 bibr27-jcbfm.2014.17 bibr12-jcbfm.2014.17 |
| References_xml | – volume: 60 start-page: 53 year: 2008 end-page: 63 article-title: Modeling the effects of dispersion and pulsatility of blood flow in pulsed arterial spin labeling publication-title: Magn Reson Med – volume: 5 start-page: 65 year: 1985 end-page: 69 article-title: What is the correct value for the brain-blood partition coefficient for water? publication-title: J Cereb Blood Flow Metab – volume: 18 start-page: 509 year: 2003 end-page: 516 article-title: Pathophysiology of Sturge–Weber syndrome publication-title: J Child Neurol – volume: 28 start-page: 897 year: 1977 end-page: 916 article-title: The [14c]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized Albino rat publication-title: J Neurochem – volume: 21 start-page: 9 year: 2003 end-page: 15 article-title: Age-related changes in the pediatric brain: proton T1 in healthy children and in children with sickle cell disease publication-title: Magn Reson Imaging – volume: 40 start-page: 383 year: 1998 end-page: 396 article-title: A general kinetic model for quantitative perfusion imaging with arterial spin labeling publication-title: Magn Reson Med – volume: 263 start-page: 527 year: 2012 end-page: 536 article-title: Longitudinal reproducibility and accuracy of pseudo-continuous arterial spin-labeled perfusion MR imaging in typically developing children publication-title: Radiology – volume: 64 start-page: 1140 year: 2010 end-page: 1147 article-title: In vivo venous blood T1 measurement using inversion recovery true-FISP in children and adults publication-title: Magn Reson Med – volume: 113 start-page: 1642 year: 2004 end-page: 1652 article-title: Brain perfusion in children: evolution with age assessed by quantitative perfusion computed tomography publication-title: Pediatrics – volume: 29 start-page: 803 year: 2009 end-page: 810 article-title: Hemodynamic etiology of elevated flow velocity and stroke in sickle-cell disease publication-title: J Cereb Blood Flow Metab – volume: 89 start-page: 212 year: 1992 end-page: 216 article-title: Magnetic resonance imaging of perfusion using spin inversion of arterial water publication-title: Proc Natl Acad Sci USA – volume: 66 start-page: 230 year: 2008 end-page: 234 article-title: Nephrogenic systemic fibrosis associated with gadolinium based contrast agents: a summary of the medical literature reporting publication-title: Eur J Radiol – volume: 10 start-page: 675 year: 1991 end-page: 690 article-title: Constructing time-specific reference ranges publication-title: Stat Med – volume: 113 start-page: 27 year: 1990 end-page: 47 article-title: Cerebral blood flow, blood volume and oxygen utilization publication-title: Brain – volume: 15 start-page: 13 year: 2013 article-title: Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5T using ShMOLLI publication-title: J Cardiovasc Magn Reson – volume: 48 start-page: 757 year: 1973 end-page: 767 article-title: Quantitative growth and development of human brain publication-title: Arch Dis Child – volume: 29 start-page: 407 year: 2003 end-page: 415 article-title: Interaction between secondary velocities, flow pulsation and vessel morphology in the common carotid artery publication-title: Ultrasound Med Biol – volume: 10 start-page: 237 year: 1997 end-page: 249 article-title: Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling publication-title: NMR Biomed – volume: 36 start-page: 345 year: 2012 end-page: 352 article-title: Arterial spin-labeling in routine clinical practice: a preliminary experience of 200 cases and correlation with MRI and clinical findings publication-title: Clin Imaging – volume: 25 start-page: 696 year: 2007 end-page: 702 article-title: Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling publication-title: J Magn Reson Imaging – volume: 23 start-page: 37 year: 1992 end-page: 45 article-title: Perfusion imaging publication-title: Magn Reson Med – volume: 18 start-page: 404 year: 2003 end-page: 413 article-title: Pediatric perfusion imaging using pulsed arterial spin labeling publication-title: J Magn Reson Imaging – volume: 117 start-page: 2119 year: 2006 end-page: 2125 article-title: Cerebral perfusion abnormalities in children with Sturge–Weber syndrome shown by dynamic contrast bolus magnetic resonance perfusion imaging publication-title: Pediatrics – volume: 17 start-page: 503 year: 1999 end-page: 515 article-title: Diffuse T1 reduction in gray matter of sickle cell disease patients: evidence of selective vulnerability to damage? publication-title: Magn Reson Imaging – volume: 24 start-page: 1305 year: 1993 end-page: 1309 article-title: Transcranial color duplex sonography in childhood and adolescence. Age dependence of flow velocities and waveform parameters publication-title: Stroke – volume: 16 start-page: 1312 year: 1996 end-page: 1318 article-title: Brain capillary perfusion during sleep publication-title: J Cereb Blood Flow Metab – volume: 32 start-page: 1973 year: 2011 end-page: 1985 article-title: Correlation between gray matter density-adjusted brain perfusion and age using brain MR images of 202 healthy children publication-title: Hum Brain Mapp – volume: 36 start-page: 217 year: 1996 end-page: 224 article-title: Perfusion imaging of the human brain at 1.5T using a single-shot EPI spin tagging approach publication-title: Magn Reson Med – volume: 227 start-page: 567 year: 2003 end-page: 574 article-title: Sickle cell disease: continuous arterial spin-labeling perfusion MR imaging in children publication-title: Radiology – volume: 50 start-page: 1699 year: 1998 end-page: 1708 article-title: Arterial territories of the human brain cerebral hemispheres publication-title: Neurology – volume: 54 start-page: 491 year: 2005 end-page: 498 article-title: Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements publication-title: Magn Reson Med – volume: 49 start-page: 477 year: 2001 end-page: 485 article-title: Perfusion magnetic resonance abnormalities in patients with sickle cell disease publication-title: Ann Neurol – volume: 101 start-page: 8174 year: 2004 end-page: 8179 article-title: Dynamic mapping of human cortical development during childhood through early adulthood publication-title: Proc Natl Acad Sci USA – volume: 107 start-page: 16988 year: 2010 end-page: 16993 article-title: Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescence publication-title: Proc Natl Acad Sci USA – volume: 51 start-page: 736 year: 2004 end-page: 743 article-title: Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects publication-title: Magn Reson Med – volume: 25 start-page: 79 year: 2012 end-page: 82 article-title: Arterial spin labelling: final steps to make it a clinical reality publication-title: MAGMA – volume: 26 start-page: 84 year: 2007 end-page: 92 article-title: The effects of flow dispersion and cardiac pulsation in arterial spin labeling publication-title: IEEE Trans Med Imaging – volume: 12 start-page: 218 year: 1997 end-page: 222 article-title: Central nervous system perfusion and metabolism abnormalities in Sturge–Weber syndrome publication-title: J Child Neurol – volume: 33 start-page: 696 year: 1992 end-page: 703 article-title: Changes in regional cerebral blood flow during brain maturation in children and adolescents publication-title: J Nucl Med – volume: 41 start-page: 1246 year: 1999 end-page: 1254 article-title: QUIPSS II with thin-slice TI periodic saturation: A method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling publication-title: Magn Reson Med – ident: bibr1-jcbfm.2014.17 doi: 10.1073/pnas.0402680101 – ident: bibr31-jcbfm.2014.17 doi: 10.1016/S0301-5629(02)00705-6 – ident: bibr29-jcbfm.2014.17 doi: 10.1073/pnas.1006025107 – ident: bibr23-jcbfm.2014.17 doi: 10.1186/1532-429X-15-13 – ident: bibr2-jcbfm.2014.17 doi: 10.1002/jmri.20839 – ident: bibr13-jcbfm.2014.17 doi: 10.1148/radiol.12111509 – ident: bibr39-jcbfm.2014.17 doi: 10.1038/jcbfm.2009.6 – ident: bibr14-jcbfm.2014.17 doi: 10.1002/mrm.22484 – ident: bibr11-jcbfm.2014.17 doi: 10.1002/(SICI)1522-2594(199906)41:6<1246::AID-MRM22>3.0.CO;2-N – ident: bibr24-jcbfm.2014.17 doi: 10.1002/sim.4780100502 – ident: bibr4-jcbfm.2014.17 doi: 10.1016/j.ejrad.2008.02.011 – ident: bibr21-jcbfm.2014.17 doi: 10.1002/mrm.20580 – ident: bibr18-jcbfm.2014.17 doi: 10.1002/jmri.10372 – ident: bibr38-jcbfm.2014.17 doi: 10.1148/radiol.2272020903 – ident: bibr40-jcbfm.2014.17 doi: 10.1016/S0730-725X(02)00635-5 – ident: bibr19-jcbfm.2014.17 doi: 10.1002/hbm.21163 – ident: bibr28-jcbfm.2014.17 doi: 10.1136/adc.48.10.757 – ident: bibr8-jcbfm.2014.17 doi: 10.1007/s10334-012-0308-9 – volume: 33 start-page: 696 year: 1992 ident: bibr26-jcbfm.2014.17 publication-title: J Nucl Med – ident: bibr37-jcbfm.2014.17 doi: 10.1002/ana.97 – ident: bibr15-jcbfm.2014.17 doi: 10.1002/mrm.1910360208 – ident: bibr5-jcbfm.2014.17 doi: 10.1002/mrm.1910230106 – ident: bibr27-jcbfm.2014.17 doi: 10.1542/peds.113.6.1642 – ident: bibr33-jcbfm.2014.17 doi: 10.1002/mrm.21654 – ident: bibr22-jcbfm.2014.17 doi: 10.1212/WNL.50.6.1699 – ident: bibr25-jcbfm.2014.17 doi: 10.1093/brain/113.1.27 – ident: bibr7-jcbfm.2014.17 doi: 10.1016/j.clinimag.2011.11.003 – ident: bibr32-jcbfm.2014.17 doi: 10.1109/TMI.2006.886807 – ident: bibr10-jcbfm.2014.17 doi: 10.1002/mrm.1910400308 – ident: bibr16-jcbfm.2014.17 doi: 10.1016/S0730-725X(98)00204-5 – ident: bibr34-jcbfm.2014.17 doi: 10.1177/08830738030180080701 – ident: bibr9-jcbfm.2014.17 doi: 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| SubjectTerms | Adolescent Adult Brain - blood supply Brain - growth & development Cerebrovascular Circulation Child Female Hemodynamics Humans Magnetic Resonance Imaging - methods Male Original Spin Labels Young Adult |
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| Title | Arterial Spin Labeling Characterization of Cerebral Perfusion during Normal Maturation from Late Childhood into Adulthood: Normal ‘Reference Range’ Values and Their Use in Clinical Studies |
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