p63 Overexpression Induces the Expression of Sonic Hedgehog

• Published in: Molecular cancer research Vol. 4; no. 10; pp. 759 - 768
• Main Authors: Caserta, Tina M, Kommagani, Ramakrishna, Yuan, Ziqiang, Robbins, David J, Mercer, Carol A, Kadakia, Madhavi P
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.10.2006
• Subjects: Animals; Binding Sites; Cell Line, Tumor; Cells, Cultured; DNA-Binding Proteins - physiology; Gene regulation and transcriptional control; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Humans; Membrane Proteins - metabolism; Membrane Proteins - physiology; Mice; Mice, Knockout; Nuclear Proteins - physiology; ORGAN SITES AND TUMOR TYPES; Phosphoproteins - genetics; Phosphoproteins - metabolism; Phosphoproteins - physiology; Promoter Regions, Genetic; Signal Transduction; Trans-Activators - genetics; Trans-Activators - metabolism; Trans-Activators - physiology; Transcriptional Activation; Tumor Protein p73; Tumor Suppressor Protein p14ARF - physiology; Tumor Suppressor Proteins - physiology

p63 and p73 are members of the p53 protein family and have been shown to play an important role in cell death, development, and tumorigenesis. In particular, p63 has been shown to be involved in the maintenance of epidermal stem cells and in the stratification of the epidermis. Sonic Hedgehog (Shh)...