S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility

• Published in: Biochemical and biophysical research communications Vol. 447; no. 3; pp. 459 - 464
• Main Authors: Chen, Na, Sato, Daisuke, Saiki, Yuriko, Sunamura, Makoto, Fukushige, Shinichi, Horii, Akira
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.05.2014
• Subjects: 60 APPLIED LIFE SCIENCES; CALCIUM; calcium-binding proteins; CARCINOGENESIS; Carcinogenesis - genetics; Cell Cycle Proteins - genetics; cell growth; Cell Line, Tumor; Cell Movement; CELL PROLIFERATION; DNA-Binding Proteins - genetics; gene expression regulation; Gene Expression Regulation, Neoplastic; gene overexpression; GENES; HISTOLOGY; Histone-Lysine N-Methyltransferase - genetics; Humans; Lung cancer; lung neoplasms; Lung Neoplasms - genetics; Lung Neoplasms - pathology; LUNGS; METASTASES; metastasis; microarray technology; Migration; neoplasm cells; NEOPLASMS; Nuclear Proteins - genetics; PANCREAS; pancreatic neoplasms; PRDM2; PROTEINS; S100 Calcium-Binding Protein A4; S100 Proteins - genetics; S100 Proteins - metabolism; S100A4; Transcription Factors - genetics; TUMOR CELLS; Cell proliferation; S100A4; PRDM2; Migration; Lung cancer

•We observed frequent overexpression of S100A4 in lung cancer cell lines.•Knockdown of S100A4 suppressed proliferation in lung cancer cells.•Forced expression of S100A4 accelerated cell motility in lung cancer cells.•PRDM2 was found to be one of the downstream suppressed genes of S100A4. S100A4, a s...