Systemic interferon type I and type II signatures in primary Sjögren's syndrome reveal differences in biological disease activity

• Published in: Rheumatology (Oxford, England) Vol. 57; no. 5; pp. 921 - 930
• Main Authors: Bodewes, Iris L A, Al-Ali, Shereen, van Helden-Meeuwsen, Cornelia G, Maria, Naomi I, Tarn, Jessica, Lendrem, Dennis W, Schreurs, Marco W J, Steenwijk, Eline C, van Daele, Paul L A, Both, Tim, Bowman, Simon J, Griffiths, Bridget, Ng, Wan-Fai, Versnel, Marjan A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2018; Oxford Publishing Limited (England)
• Subjects: Adult; Clinical trials; Female; Gene Expression Regulation; Humans; Immunoglobulin G; Interferon; Interferon Type I - biosynthesis; Interferon Type I - genetics; Interferon-gamma - biosynthesis; Interferon-gamma - genetics; Male; Middle Aged; Patients; Polymerase chain reaction; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; RNA - genetics; Severity of Illness Index; Sjogren's syndrome; Sjogren's Syndrome - diagnosis; Sjogren's Syndrome - genetics; Sjogren's Syndrome - metabolism; interferon type II; fatigue; Sjögren's syndrome; interferon type I

Abstract Objective To assess the relationships between systemic IFN type I (IFN-I) and II (IFN-II) activity and disease manifestations in primary SS (pSS). Methods RT-PCR of multiple IFN-induced genes followed by principal component analysis of whole blood RNA of 50 pSS patients was used to identify...