Long-term exposure to trihalomethanes in drinking water and breast cancer in the Spanish multicase-control study on cancer (MCC-SPAIN)

• Published in: Environment international Vol. 112; pp. 227 - 234
• Main Authors: Font-Ribera, Laia, Gràcia-Lavedan, Esther, Aragonés, Nuria, Pérez-Gómez, Beatriz, Pollán, Marina, Amiano, Pilar, Jiménez-Zabala, Ana, Castaño-Vinyals, Gemma, Roca-Barceló, Aina, Ardanaz, Eva, Burgui, Rosana, Molina, Antonio José, Fernández-Villa, Tania, Gómez-Acebo, Inés, Dierssen-Sotos, Trinidad, Moreno, Victor, Fernandez-Tardon, Guillermo, Peiró, Rosana, Kogevinas, Manolis, Villanueva, Cristina M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2018; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; breast neoplasms; Breast Neoplasms - epidemiology; bromination; Case-Control Studies; Case-control study; chloroform; chronic exposure; Drinking water; Drinking Water - adverse effects; Drinking Water - chemistry; Environmental Exposure - analysis; exposure assessment; Exposure routes; Female; females; hospitals; Humans; Long-term exposure; Middle Aged; risk factors; Spain; Spain - epidemiology; Trihalomethanes; Trihalomethanes - adverse effects; Trihalomethanes - analysis; urinary bladder neoplasms; Water Pollutants, Chemical - adverse effects; Water Pollutants, Chemical - analysis; women; Young Adult; Spain; Exposure routes; Drinking water; Long-term exposure; Case-control study; Trihalomethanes

Exposure to trihalomethanes (THMs) in drinking water has consistently been associated with an increased risk of bladder cancer, but evidence on other cancers including the breast is very limited. We assessed long-term exposure to THMs to evaluate the association with female breast cancer (BC) risk....