Hypervariable ultra-long telomeres in mice

• Published in: Nature (London) Vol. 347; no. 6291; pp. 400 - 402
• Main Authors: Kipling, David, Cooke, Howard J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.09.1990; Nature Publishing; Nature Publishing Group
• Subjects: Aging; Animals; Biological and medical sciences; Blood cells; Cell division; Chromatin. Chromosome; Chromosomes; Chromosomes - ultrastructure; Deoxyribonucleic acid; DNA; DNA - genetics; DNA Restriction Enzymes; Enzymes; Family studies; Fragments; Fundamental and applied biological sciences. Psychology; Genetics; Genomes; Humanities and Social Sciences; Humans; Hybridization; letter; Male; Mice - genetics; Mice, Inbred BALB C - genetics; Mice, Inbred C57BL - genetics; Mice, Inbred CBA - genetics; Mice, Inbred DBA - genetics; Molecular and cellular biology; Molecular genetics; multidisciplinary; Nucleic Acid Hybridization; Oligonucleotides; Peripheral blood; Polymorphism, Genetic; Repetitive Sequences, Nucleic Acid; Rodents; Science; Telomerase; Telomeres; Vertebrates; Yeasts; Vertebrata; Mammalia; Restriction fragment length polymorphism; Mouse; Family study; Repeated sequence; DNA; Rodentia; Inheritance; Chromosome; Strain specificity; Telomer

TELOMERE structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG) n , as shown by in...