Hypervariable ultra-long telomeres in mice
TELOMERE structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG) n , as shown by in...
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| Published in | Nature (London) Vol. 347; no. 6291; pp. 400 - 402 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
27.09.1990
Nature Publishing Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | TELOMERE structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG)
n
, as shown by
in situ
hybridization
2,3
. In humans, these terminal repeats are heterogeneous in length, averaging about 10 kilobases in blood cells
4–6
. Here we report the structure and inheritance of the terminal repeats present at mouse telomeres. The (TTAGGG)
n
tracts are many times larger than those present at human telomeres. Because of their constancy in length through somatic cell divisions, they are resolved as multiple discrete restriction fragments of up to 150 kilobases. Strikingly, this banding pattern is highly polymorphic within populations of inbred mice, suggesting an unusually high mutation rate. Indeed, although the banding pattern is inherited in a largely mendelian fashion, (TTAGGG)
n
tracts of new size appear frequently in family studies. |
|---|---|
| AbstractList | The (TTAGGG)„ tracts are many times larger than those present at human telomeres. Because of their constancy in length through somatic cell divisions, they are resolved as multiple discrete restriction fragments of up to 150 kilobases. When human DNA from peripheral blood cells is digested with a frequently cutting restriction enzyme, hybridization with a (TTAGGG)4 oligonucleotide probe detects a range of terminal fragment sizes, averaging around 10 kilobases (kb) (refs 4-6). Large fragments, similar in size, are seen after digestion with BamHl, BglU, Eco RI, HındlII, Hinti, Mspl, Нае III, Rsa I, Mbo I, Sau ЗА or Alu I. (Small differences are seen, some of which may reflect varying amounts of flanking DNA included in the fragments.) The banding pattern seen with DNA from a CBA/Ca individual digested with five different enzymes, each with a 4-bp recognition sequence, is illustrated in Fig. 2. The shortening of human telomeres during ageing in vivo10 may instead indicate that telomere maintenance is another metabolic process that senescent cells are unable to perform as efficiently. □ * To whom correspondence should be addressed. Telomere structure and behavior is less well understood in vertebrates than it is in ciliates and yeasts. The telomere structure of vertebrates terminate in an array of a short repeated sequence. The structure and inheritance of the repeats present at mouse telomeres is reported. TELOMERE structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG) n , as shown by in situ hybridization 2,3 . In humans, these terminal repeats are heterogeneous in length, averaging about 10 kilobases in blood cells 4–6 . Here we report the structure and inheritance of the terminal repeats present at mouse telomeres. The (TTAGGG) n tracts are many times larger than those present at human telomeres. Because of their constancy in length through somatic cell divisions, they are resolved as multiple discrete restriction fragments of up to 150 kilobases. Strikingly, this banding pattern is highly polymorphic within populations of inbred mice, suggesting an unusually high mutation rate. Indeed, although the banding pattern is inherited in a largely mendelian fashion, (TTAGGG) n tracts of new size appear frequently in family studies. Telomere structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG)n, as shown by in situ hybridization. In humans, these terminal repeats are heterogeneous in length, averaging about 10 kilobases in blood cells. Here we report the structure and inheritance of the terminal repeats present at mouse telomeres. The (TTAGGG)n tracts are many times larger than those present at human telomeres. Because of their constancy in length through somatic cell divisions, they are resolved as multiple discrete restriction fragments of up to 150 kilobases. Strikingly, this banding pattern is highly polymorphic within populations of inbred mice, suggesting an unusually high mutation rate. Indeed, although the banding pattern is inherited in a largely mendelian fashion, (TTAGGG)n tracts of new size appear frequently in family studies. Telomere structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts. Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG) sub(n), as shown by in situ hybridization. In humans, these terminal repeats are heterogeneous in length, averaging about 10 kilobases in blood cells. Here we report the structure and inheritance of the terminal repeats present at mouse telomeres. The (TTAGGG) sub(n) tracts are many times larger than those present at human telomeres. Because of their constance in length through somatic cell divisions, they are resolved as multiple discrete restriction fragments of up to 150 kilobases. Strikingly, this banding pattern is highly polymorphic within populations of inbred mice, suggesting an unusually high mutation rate. |
| Author | Kipling, David Cooke, Howard J |
| Author_xml | – sequence: 1 givenname: David surname: Kipling fullname: Kipling, David – sequence: 2 givenname: Howard J surname: Cooke fullname: Cooke, Howard J |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19463711$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/2170845$$D View this record in MEDLINE/PubMed |
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| CODEN | NATUAS |
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| Cites_doi | 10.1093/nar/17.12.4611 10.1073/pnas.87.5.1758 10.1016/0092-8674(87)90493-4 10.1146/annurev.ge.23.120189.003051 10.1073/pnas.86.18.7049 10.1093/nar/11.20.6965 10.1038/338771a0 10.1038/345458a0 10.1073/pnas.85.18.6622 10.1016/0092-8674(89)90112-8 |
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| Keywords | Vertebrata Mammalia Restriction fragment length polymorphism Mouse Family study Repeated sequence DNA Rodentia Inheritance Chromosome Strain specificity Telomer |
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| References | Levis, R. W. (b8) 1989; 58 Zakian, V. A. (b1) 1989; 23 Cross, S. H., Allshire, R. C., McKay, S. J., McGill, N. I., Cooke, H. J. (b5) 1989; 338 Moyzis, R. K. (b2) 1988; 85 Meyne, J., Ratliff, R. L., Moyzis, R. K. (b3) 1989; 86 de Lange, T. (b6) 1990; 10 Allshire, R. C. (b11) 1987; 50 Pietras, D. F. (b12) 1983; 11 Alishire, R. C., Dempster, M., Hastie, N. D. (b4) 1989; 17 Harley, C. B., Futcher, A. B., Greider, C. W. (b9) 1990; 345 Hastie, N. O. (b10) Biessmann, H., Carter, S. B., Mason, J. M. (b7) 1990; 87 RC Alishire (BF347400a0_CR4) 1989; 17 H Biessmann (BF347400a0_CR7) 1990; 87 VA Zakian (BF347400a0_CR1) 1989; 23 RK Moyzis (BF347400a0_CR2) 1988; 85 J Meyne (BF347400a0_CR3) 1989; 86 T de Lange (BF347400a0_CR6) 1990; 10 RW Levis (BF347400a0_CR8) 1989; 58 CB Harley (BF347400a0_CR9) 1990; 345 SH Cross (BF347400a0_CR5) 1989; 338 BF347400a0_CR10 RC Allshire (BF347400a0_CR11) 1987; 50 DF Pietras (BF347400a0_CR12) 1983; 11 |
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| Snippet | TELOMERE structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic... Telomere structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic... The (TTAGGG)„ tracts are many times larger than those present at human telomeres. Because of their constancy in length through somatic cell divisions, they are... Telomere structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts. Like all other eukaryotic chromosomes, those of... Telomere structure and behavior is less well understood in vertebrates than it is in ciliates and yeasts. The telomere structure of vertebrates terminate in an... |
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| SubjectTerms | Aging Animals Biological and medical sciences Blood cells Cell division Chromatin. Chromosome Chromosomes Chromosomes - ultrastructure Deoxyribonucleic acid DNA DNA - genetics DNA Restriction Enzymes Enzymes Family studies Fragments Fundamental and applied biological sciences. Psychology Genetics Genomes Humanities and Social Sciences Humans Hybridization letter Male Mice - genetics Mice, Inbred BALB C - genetics Mice, Inbred C57BL - genetics Mice, Inbred CBA - genetics Mice, Inbred DBA - genetics Molecular and cellular biology Molecular genetics multidisciplinary Nucleic Acid Hybridization Oligonucleotides Peripheral blood Polymorphism, Genetic Repetitive Sequences, Nucleic Acid Rodents Science Telomerase Telomeres Vertebrates Yeasts |
| Title | Hypervariable ultra-long telomeres in mice |
| URI | http://dx.doi.org/10.1038/347400a0 https://link.springer.com/article/10.1038/347400a0 https://www.ncbi.nlm.nih.gov/pubmed/2170845 https://www.proquest.com/docview/204427236 https://www.proquest.com/docview/2233935291 https://search.proquest.com/docview/15788422 https://search.proquest.com/docview/743250671 https://search.proquest.com/docview/80047732 |
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