Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non–A–E Hepatitis

• Published in: The Journal of infectious diseases Vol. 188; no. 10; pp. 1545 - 1552
• Main Authors: Umemura, Takeji, Tanaka, Eiji, Ostapowicz, George, Brown, Kevin E., Heringlake, Stefan, Tassopoulos, Nicolaos C., Wang, Richard Y.-H., Yeo, Anthony E. T., Shih, J. Wai-Kuo, Orii, Koji, Young, Neal S., Hatzakis, Angelos, Manns, Michael P., Lee, William M., Kiyosawa, Kendo, Alter, Harvey J.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.11.2003; University of Chicago Press; Oxford University Press
• Subjects: Acute liver failure; Adolescent; Adult; Aged; Anemia, Aplastic - epidemiology; Anemia, Aplastic - virology; Aplastic anemia; Biological and medical sciences; Blood donation; Blood transfusion; Child; Chronic hepatitis; Circoviridae - genetics; Circoviridae - growth & development; Circoviridae Infections - epidemiology; Circoviridae Infections - virology; DNA, Viral - chemistry; DNA, Viral - genetics; Female; Fundamental and applied biological sciences. Psychology; Germany - epidemiology; Greece - epidemiology; Hepatitis; Hepatitis B virus; Hepatitis Viruses - growth & development; Hepatitis, Chronic - epidemiology; Hepatitis, Chronic - virology; Human viral diseases; Humans; Infections; Infectious diseases; Japan - epidemiology; Liver diseases; Liver Failure, Acute - epidemiology; Liver Failure, Acute - virology; Male; Medical sciences; Microbiology; Middle Aged; Polymerase Chain Reaction; Prevalence; SEN virus; Torque teno virus; United States - epidemiology; Viral diseases; Viral hepatitis; Viruses; Greece; United States; Japan; Germany; Human; Microbiology; Acute; Aplastic anemia; Hepatic disease; Hemopathy; Infection; Viral hepatitis A; Chronic; Liver failure; Viral disease; Digestive diseases; Viral hepatitis E

SEN virus (SENV) has been tentatively linked to transfusion-associated non–A–E hepatitis. We investigated SENV’s role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV...