Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non–A–E Hepatitis
SEN virus (SENV) has been tentatively linked to transfusion-associated non–A–E hepatitis. We investigated SENV’s role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV...
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| Published in | The Journal of infectious diseases Vol. 188; no. 10; pp. 1545 - 1552 |
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| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chicago, IL
The University of Chicago Press
15.11.2003
University of Chicago Press Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-1899 1537-6613 |
| DOI | 10.1086/379216 |
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| Abstract | SEN virus (SENV) has been tentatively linked to transfusion-associated non–A–E hepatitis. We investigated SENV’s role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non–A–E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated |
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| AbstractList | SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated. SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated.SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated. SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitisassociated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10o%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated. |
| Author | Heringlake, Stefan Tassopoulos, Nicolaos C. Yeo, Anthony E. T. Tanaka, Eiji Shih, J. Wai-Kuo Lee, William M. Young, Neal S. Orii, Koji Alter, Harvey J. Hatzakis, Angelos Kiyosawa, Kendo Brown, Kevin E. Manns, Michael P. Ostapowicz, George Umemura, Takeji Wang, Richard Y.-H. |
| Author_xml | – sequence: 1 givenname: Takeji surname: Umemura fullname: Umemura, Takeji organization: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, and – sequence: 2 givenname: Eiji surname: Tanaka fullname: Tanaka, Eiji organization: Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan – sequence: 3 givenname: George surname: Ostapowicz fullname: Ostapowicz, George organization: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas – sequence: 4 givenname: Kevin E. surname: Brown fullname: Brown, Kevin E. organization: Hematology Branch, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland – sequence: 5 givenname: Stefan surname: Heringlake fullname: Heringlake, Stefan organization: Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany – sequence: 6 givenname: Nicolaos C. surname: Tassopoulos fullname: Tassopoulos, Nicolaos C. organization: First Department of Medicine, Western Attica General Hospital, and – sequence: 7 givenname: Richard Y.-H. surname: Wang fullname: Wang, Richard Y.-H. organization: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, and – sequence: 8 givenname: Anthony E. T. surname: Yeo fullname: Yeo, Anthony E. T. organization: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, and – sequence: 9 givenname: J. Wai-Kuo surname: Shih fullname: Shih, J. Wai-Kuo organization: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, and – sequence: 10 givenname: Koji surname: Orii fullname: Orii, Koji organization: Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan – sequence: 11 givenname: Neal S. surname: Young fullname: Young, Neal S. organization: Hematology Branch, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland – sequence: 12 givenname: Angelos surname: Hatzakis fullname: Hatzakis, Angelos organization: Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece – sequence: 13 givenname: Michael P. surname: Manns fullname: Manns, Michael P. organization: Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany – sequence: 14 givenname: William M. surname: Lee fullname: Lee, William M. organization: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas – sequence: 15 givenname: Kendo surname: Kiyosawa fullname: Kiyosawa, Kendo organization: Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan – sequence: 16 givenname: Harvey J. surname: Alter fullname: Alter, Harvey J. email: halter@dtm.cc.nih.gov organization: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, and |
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| Keywords | Human Microbiology Acute Aplastic anemia Hepatic disease Hemopathy Infection Viral hepatitis A Chronic Liver failure Viral disease Digestive diseases Viral hepatitis E |
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| Snippet | SEN virus (SENV) has been tentatively linked to transfusion-associated non–A–E hepatitis. We investigated SENV’s role in unexplained hepatitis in other... SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other... |
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| SubjectTerms | Acute liver failure Adolescent Adult Aged Anemia, Aplastic - epidemiology Anemia, Aplastic - virology Aplastic anemia Biological and medical sciences Blood donation Blood transfusion Child Chronic hepatitis Circoviridae - genetics Circoviridae - growth & development Circoviridae Infections - epidemiology Circoviridae Infections - virology DNA, Viral - chemistry DNA, Viral - genetics Female Fundamental and applied biological sciences. Psychology Germany - epidemiology Greece - epidemiology Hepatitis Hepatitis B virus Hepatitis Viruses - growth & development Hepatitis, Chronic - epidemiology Hepatitis, Chronic - virology Human viral diseases Humans Infections Infectious diseases Japan - epidemiology Liver diseases Liver Failure, Acute - epidemiology Liver Failure, Acute - virology Male Medical sciences Microbiology Middle Aged Polymerase Chain Reaction Prevalence SEN virus Torque teno virus United States - epidemiology Viral diseases Viral hepatitis Viruses |
| Title | Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non–A–E Hepatitis |
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