Activation of subthalamic neurons produces NMDA receptor-mediated dendritic dopamine release in substantia nigra pars reticulata: a microdialysis study in the rat
Here we have studied whether the activation of the subthalamic neurons induces the release of dopamine (DA) from dopaminergic dendrites in the pars reticulata of the substantia nigra. Subthalamic neurons were activated by carbachol microinjected into the subthalamic nucleus. A microdialysis probe wa...
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Published in | Brain research Vol. 645; no. 1; pp. 335 - 337 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
Elsevier B.V
09.05.1994
Amsterdam Elsevier New York, NY |
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Abstract | Here we have studied whether the activation of the subthalamic neurons induces the release of dopamine (DA) from dopaminergic dendrites in the pars reticulata of the substantia nigra. Subthalamic neurons were activated by carbachol microinjected into the subthalamic nucleus. A microdialysis probe was implanted in the medial aspect of the pars reticulata to collect samples of the perfusate. Carbachol (1 μg/0.25 μl saline) enhanced (58 ± 8% over basal values) nigral DA release. The enhancement was fully blocked by the NMDA antagonist AP5 added to the microdialysis medium perfusing the pars reticulata. Perfusion of the pars reticulata with NMDA also increased (125 ± 25% over basal) nigral DA release. Again, AP5 reversed the effect. These results suggest that activation of the glutamatergic subthalamonigral pathway enhances dendritic DA release by activating NMDA receptors present on dopaminergic dendrites. |
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AbstractList | Here we have studied whether the activation of the subthalamic neurons induces the release of dopamine (DA) from dopaminergic dendrites in the pars reticulata of the substantia nigra. Subthalamic neurons were activated by carbachol microinjected into the subthalamic nucleus. A microdialysis probe was implanted in the medial aspect of the pars reticulata to collect samples of the perfusate. Carbachol (1 microgram/0.25 microliter saline) enhanced (58 +/- 8% over basal values) nigral DA release. The enhancement was fully blocked by the NMDA antagonist AP5 added to the microdialysis medium perfusing the pars reticulata. Perfusion of the pars reticulata with NMDA also increased (125 +/- 25% over basal) nigral DA release. Again, AP5 reversed the effect. These results suggest that activation of the glutamatergic subthalamonigral pathway enhances dendritic DA release by activating NMDA receptors present on dopaminergic dendrites. Here we have studied whether the activation of the subthalamic neurons induces the release of dopamine (DA) from dopaminergic dendrites in the pars reticulata of the substantia nigra. Subthalamic neurons were activated by carbachol microinjected into the subthalamic nucleus. A microdialysis probe was implanted in the medial aspect of the pars reticulata to collect samples of the perfusate. Carbachol enhanced nigral DA release. The enhancement was fully blocked by the NMDA antagonist AP5 added to the microdialysis medium perfusing the pars reticulata. Perfusion of the pars reticulata with NMDA also increased nigral DA release. Again, AP5 reversed the effect. The results suggest that activation of the glutamatergic subthalamonigral pathway enhances dendritic DA release by activating NMDA receptors present on dopaminergic dendrites. Here we have studied whether the activation of the subthalamic neurons induces the release of dopamine (DA) from dopaminergic dendrites in the pars reticulata of the substantia nigra. Subthalamic neurons were activated by carbachol microinjected into the subthalamic nucleus. A microdialysis probe was implanted in the medial aspect of the pars reticulata to collect samples of the perfusate. Carbachol (1 μg/0.25 μl saline) enhanced (58 ± 8% over basal values) nigral DA release. The enhancement was fully blocked by the NMDA antagonist AP5 added to the microdialysis medium perfusing the pars reticulata. Perfusion of the pars reticulata with NMDA also increased (125 ± 25% over basal) nigral DA release. Again, AP5 reversed the effect. These results suggest that activation of the glutamatergic subthalamonigral pathway enhances dendritic DA release by activating NMDA receptors present on dopaminergic dendrites. |
Author | Aceves, Jorge Flores, Gonzalo Martínez-Fong, Daniel Hernández, Salvador Rosales, Manuel G. |
Author_xml | – sequence: 1 givenname: Manuel G. surname: Rosales fullname: Rosales, Manuel G. – sequence: 2 givenname: Gonzalo surname: Flores fullname: Flores, Gonzalo – sequence: 3 givenname: Salvador surname: Hernández fullname: Hernández, Salvador – sequence: 4 givenname: Daniel surname: Martínez-Fong fullname: Martínez-Fong, Daniel – sequence: 5 givenname: Jorge surname: Aceves fullname: Aceves, Jorge |
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Keywords | Dopamine Dopamine release Substantia nigra Glutamate receptor Subthalamic nucleus Brain microdialysis Glutamate NMDA receptor Rat Rodentia Central nervous system Catecholamine Vertebrata Mammalia Locus niger Microdialysis Neurotransmitter Release Brain (vertebrata) |
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Snippet | Here we have studied whether the activation of the subthalamic neurons induces the release of dopamine (DA) from dopaminergic dendrites in the pars reticulata... |
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SubjectTerms | Animals Biological and medical sciences Brain microdialysis Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dendrites - metabolism Dopamine Dopamine - metabolism Dopamine release Fundamental and applied biological sciences. Psychology Glutamate Glutamate receptor Male Microdialysis NMDA receptor Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - physiology Substantia nigra Substantia Nigra - metabolism Subthalamic nucleus Thalamic Nuclei - cytology Thalamic Nuclei - physiology Vertebrates: nervous system and sense organs |
Title | Activation of subthalamic neurons produces NMDA receptor-mediated dendritic dopamine release in substantia nigra pars reticulata: a microdialysis study in the rat |
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