Selective removal of stratum corneum by microdermabrasion to increase skin permeability

• Published in: European journal of pharmaceutical sciences Vol. 38; no. 2; pp. 95 - 103
• Main Authors: Gill, Harvinder S., Andrews, Samantha N., Sakthivel, Senthilkumar K., Fedanov, Andrew, Williams, Ifor R., Garber, David A., Priddy, Frances H., Yellin, Seth, Feinberg, Mark B., Staprans, Silvija I., Prausnitz, Mark R.
• Format: Journal Article
• Language: English
• Published: Kindlington Elsevier B.V 10.09.2009; Elsevier
• Subjects: Adolescent; Adult; Aged; Animals; Biological and medical sciences; Dermabrasion; Female; General pharmacology; Humans; Macaca mulatta; Male; Medical sciences; Microdermabrasion; Microscopy, Electron, Scanning; Permeability; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Skin Absorption; Skin histology; Skin permeability; Stratum corneum removal; Transdermal drug delivery; Vaccination; Vaccinia virus; Vaccinia virus; Skin permeability; Vaccination; Transdermal drug delivery; Stratum corneum removal; Skin histology; Microdermabrasion; Drug; Chordopoxvirinae; Stratum corneum; Pharmaceutical technology; Orthopoxvirus; Histology; Permeability; Percutaneous route; Virus; Poxviridae; Skin

This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been used for cosmetic treatment of skin for decades, no study has assessed the detailed effects of microdermabrasion conditions on the degree of...