Selective removal of stratum corneum by microdermabrasion to increase skin permeability

This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been used for cosmetic treatment of skin for decades, no study has assessed the detailed effects of microdermabrasion conditions on the degree of...

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Published inEuropean journal of pharmaceutical sciences Vol. 38; no. 2; pp. 95 - 103
Main Authors Gill, Harvinder S., Andrews, Samantha N., Sakthivel, Senthilkumar K., Fedanov, Andrew, Williams, Ifor R., Garber, David A., Priddy, Frances H., Yellin, Seth, Feinberg, Mark B., Staprans, Silvija I., Prausnitz, Mark R.
Format Journal Article
LanguageEnglish
Published Kindlington Elsevier B.V 10.09.2009
Elsevier
Subjects
Adolescent
Adult
Aged
Animals
Biological and medical sciences
Dermabrasion
Female
General pharmacology
Humans
Macaca mulatta
Male
Medical sciences
Microdermabrasion
Microscopy, Electron, Scanning
Permeability
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Skin Absorption
Skin histology
Skin permeability
Stratum corneum removal
Transdermal drug delivery
Vaccination
Vaccinia virus
Vaccinia virus
Skin permeability
Vaccination
Transdermal drug delivery
Stratum corneum removal
Skin histology
Microdermabrasion
Drug
Chordopoxvirinae
Stratum corneum
Pharmaceutical technology
Orthopoxvirus
Histology
Permeability
Percutaneous route
Virus
Poxviridae
Skin
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Abstract This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been used for cosmetic treatment of skin for decades, no study has assessed the detailed effects of microdermabrasion conditions on the degree of skin tissue removal. Therefore, we histologically characterized the skin of rhesus macaques and human volunteers after microdermabrasion at different conditions. Using mobile tip microdermabrasion, an increase in the number of treatment passes led to greater tissue removal ranging from minimal effects to extensive damage to deeper layers of the skin. Of note, these data showed for the first time that at moderate microdermabrasion conditions selective yet full-thickness removal of stratum corneum could be achieved with little damage to deeper skin tissues. In the stationary mode of microdermabrasion, selective stratum corneum removal was not observed, but micro-blisters could be seen. Similar tissue removal trends were observed in human volunteers. As proof of concept for drug delivery applications, a model fluorescent drug (fluorescein) was delivered through microdermabraded skin and antibodies were generated against vaccinia virus after its topical application in monkeys. In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability.
AbstractList This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been used for cosmetic treatment of skin for decades, no study has assessed the detailed effects of microdermabrasion conditions on the degree of skin tissue removal. Therefore, we histologically characterized the skin of rhesus macaques and human volunteers after microdermabrasion at different conditions. Using mobile tip microdermabrasion, an increase in the number of treatment passes led to greater tissue removal ranging from minimal effects to extensive damage to deeper layers of the skin. Of note, these data showed for the first time that at moderate microdermabrasion conditions selective yet full-thickness removal of stratum corneum could be achieved with little damage to deeper skin tissues. In the stationary mode of microdermabrasion, selective stratum corneum removal was not observed, but micro-blisters could be seen. Similar tissue removal trends were observed in human volunteers. As proof of concept for drug delivery applications, a model fluorescent drug (fluorescein) was delivered through microdermabraded skin and antibodies were generated against vaccinia virus after its topical application in monkeys. In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability.
Author Williams, Ifor R.
Priddy, Frances H.
Fedanov, Andrew
Yellin, Seth
Prausnitz, Mark R.
Gill, Harvinder S.
Garber, David A.
Andrews, Samantha N.
Feinberg, Mark B.
Sakthivel, Senthilkumar K.
Staprans, Silvija I.
AuthorAffiliation 4 Division of Infectious Disease, Department of Medicine, Emory University School of Medicine
5 Department of Otolaryngology, Emory University
6 School of Chemical and Biomolecular Engineering, Georgia Institute of Technology
3 Emory Vaccine Center, Emory University
1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
2 Department of Pathology and Laboratory Medicine, Emory University
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Issue 2
Keywords Vaccinia virus
Skin permeability
Vaccination
Transdermal drug delivery
Stratum corneum removal
Skin histology
Microdermabrasion
Drug
Chordopoxvirinae
Stratum corneum
Pharmaceutical technology
Orthopoxvirus
Histology
Permeability
Percutaneous route
Virus
Poxviridae
Skin
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Snippet This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been...
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StartPage 95
SubjectTerms Adolescent
Adult
Aged
Animals
Biological and medical sciences
Dermabrasion
Female
General pharmacology
Humans
Macaca mulatta
Male
Medical sciences
Microdermabrasion
Microscopy, Electron, Scanning
Permeability
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Skin Absorption
Skin histology
Skin permeability
Stratum corneum removal
Transdermal drug delivery
Vaccination
Vaccinia virus
Title Selective removal of stratum corneum by microdermabrasion to increase skin permeability
URI https://dx.doi.org/10.1016/j.ejps.2009.06.004
https://www.ncbi.nlm.nih.gov/pubmed/19559791
https://pubmed.ncbi.nlm.nih.gov/PMC2731013
Volume 38
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