Acute cholestatic liver injury caused by polyhexamethyleneguanidine hydrochloride admixed to ethyl alcohol

• Published in: Clinical toxicology (Philadelphia, Pa.) Vol. 49; no. 6; pp. 471 - 477
• Main Authors: Ostapenko, Y. N., Brusin, K. M., Zobnin, Y. V., Shchupak, A. Y., Vishnevetskiy, M. K., Sentsov, V. G., Novikova, O. V., Alekseenko, S. A., Lebed'Ko, O. A., Puchkov, Y. B.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.07.2011; Taylor & Francis
• Subjects: Acute Disease; Adolescent; Adult; Age Factors; Aged; Alcoholic Beverages - poisoning; Central Nervous System Depressants - poisoning; Chemical and Drug Induced Liver Injury - diagnostic imaging; Chemical and Drug Induced Liver Injury - pathology; Cholestasis - diagnostic imaging; Cholestasis - pathology; Cholestatic hepatitis; Clinical Laboratory Techniques; Disinfectants - poisoning; Epidemics; Ethanol - poisoning; Female; Guanidines - poisoning; Hepatic Encephalopathy - chemically induced; Hepatic Encephalopathy - psychology; Humans; Liver - pathology; Liver Function Tests; Male; Middle Aged; Poisoning; Poisoning - diagnosis; Poisoning - epidemiology; Poisoning - mortality; Polyhexamethyleneguanidine hydrochloride; Retrospective Studies; Russia - epidemiology; Sex Factors; Social Class; Ultrasonography; Young Adult

Introduction. Polyhexamethyleneguanidine hydrochloride (PHMG) is an antimicrobial biocide of the guanidine family. In the period from August 2006 to May 2007, more than 12500 patients were admitted to hospital with a history of drinking illegal cheap "vodka" in 44 different regions in Russ...