Comparison of hazard models with and without consideration of competing risks to assess the effect of neoadjuvant chemotherapy on locoregional recurrence among breast cancer patients

• Published in: Journal of cancer research and therapeutics Vol. 17; no. 4; pp. 982 - 987
• Main Authors: Pathak, Mona, S. Deo, Surya, Dwivedi, Sada, Vishnubhatla, Sreenivas, Thakur, Bhaskar
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.07.2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Breast cancer; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Care and treatment; Chemotherapy; Chemotherapy, Adjuvant - adverse effects; Combined Modality Therapy; Diseases; Female; Follow-Up Studies; Humans; India - epidemiology; Mastectomy - adverse effects; Medical prognosis; Metastasis; Middle Aged; Neoadjuvant therapy; Neoadjuvant Therapy - adverse effects; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - etiology; Neoplasm Recurrence, Local - pathology; Patient outcomes; Prognosis; Proportional Hazards Models; Radiation therapy; Relapse; Retrospective Studies; Risk Factors; Surgery; Survival analysis; Survival Rate; Young Adult; India; Cause-specific hazard model; cumulative incidence competing risk; sub-distribution hazard model; Fine and Gray model; distant metastasis

Context: While analyzing locoregional recurrences (LRRs), it is necessary to consider distant metastasis as a competing event. Because, later one is more fatal than LRR. It may change ongoing treatment of breast cancer and may alter the chance of LRR. Although some earlier studies assessed the effec...