Targeting glycolysis in Th2 cells by pterostilbene attenuates clinical severities in an asthmatic mouse model and IL‐4 production in peripheral blood from asthmatic patients

• Published in: Immunology Vol. 166; no. 2; pp. 222 - 237
• Main Authors: Liu, Chuan‐Teng, Song, Ying‐Chyi, Wu, Tsai‐Chen, Shiung, Ko‐Chieh, Chen, I‐Hsuan, Chang, Tung‐Ti, Liang, Shinn‐Jye, Yen, Hung‐Rong
• Format: Journal Article
• Language: English
• Published: England Wiley 01.06.2022; Wiley Subscription Services, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; Accumulation; Acetylation; Adoptive transfer; Animal models; Animals; Asthma; Asthma - drug therapy; Blood; CD4 antigen; Cell activation; Cytokines; Cytokines - metabolism; Disease Models, Animal; Eosinophils; GATA-3 protein; Glucose; Glucose - metabolism; Glycolysis; Health services; Helper cells; Histones; Histones - metabolism; House dust; house dust mite; Humans; Immunoglobulin E; Immunoglobulin G; Inflammation; Interleukin-4; Interleukin-4 - metabolism; Interleukins; Leukocytes (eosinophilic); Leukocytes, Mononuclear; Leukocytes, Mononuclear - metabolism; Lymphocytes; Lymphocytes T; Medical treatment; Mice; Monocytes; Morbidity; Patients; Peripheral blood mononuclear cells; pterostilbene; Pyroglyphidae; Pyroglyphidae - metabolism; Respiratory tract; Respiratory tract diseases; Side effects; Steroid hormones; Stilbenes; Stilbenes - pharmacology; Supplements; Th2 Cells; TOR Serine-Threonine Kinases; TOR Serine-Threonine Kinases - metabolism; type 2 helper T cells; type 2 helper T cells; asthma; house dust mite; glycolysis; pterostilbene

Asthma, a major non‐communicable disease, affects both adults and children and is associated with high morbidity compared with other chronic diseases. The glycolysis‐associated activation of type 2 helper T (Th2) cells is the critical immunopathological mechanism involved in asthma deterioration. Lo...