Mucosal immunoglobulin‐A and ‐G responses to oncogenic human papilloma virus capsids

• Published in: International journal of cancer Vol. 104; no. 3; pp. 328 - 335
• Main Authors: Sasagawa, Toshiyuki, Rose, Robert C., Azar, Khadijeh K., Sakai, Akemi, Inoue, Masaki
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 10.04.2003; Wiley-Liss
• Subjects: Adolescent; Adult; Aged; Antibodies, Neoplasm - immunology; Antibodies, Viral - immunology; Biological and medical sciences; Capsid; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - virology; cervical cancer; Cervical Intraepithelial Neoplasia - genetics; Cervical Intraepithelial Neoplasia - immunology; Cervical Intraepithelial Neoplasia - virology; Cervix Mucus - immunology; DNA, Viral - analysis; ELISA; Enzyme-Linked Immunosorbent Assay; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Immunoglobulin A - immunology; Immunoglobulin G - immunology; Longitudinal Studies; Medical sciences; Middle Aged; mucosal antibody; oncogenic HPV types; Papillomaviridae - immunology; Papillomavirus Infections - immunology; Papillomavirus Infections - pathology; Time Factors; Tumor Virus Infections - immunology; Tumor Virus Infections - pathology; Tumors; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - immunology; Uterine Cervical Neoplasms - virology; Asia; Japan; Human; Squamous cell carcinoma; IgA; Immunoglobulins; Immune response; Mucosa; IgG; Papovaviridae; Malignant tumor; Uterine cervix; Epidemiology; Female genital diseases; Infection; Papillomavirus; Virus; Human papillomavirus; Oncogenic virus; Viral disease; Capsid; Uterine cervix diseases; Public health; Humoral immunity
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.10939

Oncogenic human papilloma virus (HPV) infection is the most important risk factor for developing cervical cancer. It is known that serum antibody responses against these viruses are associated with persistent infection. We conducted an epidemiological study of 627 women to detect cervical mucosal im...