Longitudinal Changes of Bone Mineral Density and Metabolism in Antiretroviral-Treated Human Immunodeficiency Virus-Infected Children

• Published in: The journal of clinical endocrinology and metabolism Vol. 89; no. 1; pp. 24 - 28
• Main Authors: Mora, Stefano, Zamproni, Ilaria, Beccio, Sabrina, Bianchi, Roberta, Giacomet, Vania, Viganò, Alessandra
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.01.2004; Copyright by The Endocrine Society
• Subjects: Absorptiometry, Photon; Adolescent; Adult; Alkaline Phosphatase - blood; Antiretroviral Therapy, Highly Active - adverse effects; Biological and medical sciences; Bone and Bones - enzymology; Bone and Bones - metabolism; Bone Density; Bone Diseases, Metabolic - epidemiology; Bone Diseases, Metabolic - etiology; Bone Remodeling; Bone Resorption; Child; Child, Preschool; Collagen - urine; Collagen Type I; Drug toxicity and drugs side effects treatment; Female; highly active antiretroviral therapy; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - physiopathology; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Longitudinal Studies; Lumbar Vertebrae; Male; Medical sciences; Peptides - urine; Pharmacology. Drug treatments; Toxicity: osteoarticular system; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Drug combination; HIV-1 virus; Toxicity; Retroviridae; AIDS; Metabolism; Immune deficiency; Lentivirus; Infection; Virus; Chemotherapy; Treatment; Viral disease; Antiviral; Complication; Bone mineral density; Human immunodeficiency virus; Osseous tissue; Child

Highly active antiretroviral therapy (HAART) may be a contributory factor for a decreased bone mass and altered bone metabolism in HIV-infected children. However, the evolution of bone mineral density (BMD) and bone metabolism during HAART has not been studied yet. In the current longitudinal study...