Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution - Cunha, Eva S.; Chen, Xiaorui; Sanz-Gaitero, Marta; Mills, Deryck J.; Luecke, Hartmut (Nature communications, 2021)
Keywords: 101/28; 147/28; 631/154; 631/326/421; 631/45/607/1164; 631/535/1258/1259; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Broadband; Cancer; Catalytic Domain; Clarithromycin; Colonization; Cryoelectron Microscopy; Cytoplasm; Drug development; Electron microscopy; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Eradication; Gastric cancer; Helicobacter pylori; Helicobacter pylori - enzymology; Humanities and Social Sciences; Hydrogen-Ion Concentration; Infections; Inhibitors; Metronidazole; Models, Molecular; multidisciplinary; Nickel; Peptic ulcers; Proton pump inhibitors; Science; Science (multidisciplinary); Stomach; Therapeutic targets; Ulcers; Urease; Urease - antagonists & inhibitors; Urease - ultrastructure; World population