Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion

• Published in: The journal of obstetrics and gynaecology research Vol. 42; no. 11; pp. 1439 - 1444
• Main Authors: Hou, Wenhui, Li, Zhuyu, Li, Yinguang, Fang, Liyuan, Li, Jie, Huang, Jia, Li, Xiaoqing, You, Zeshan
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.11.2016; Wiley Subscription Services, Inc
• Subjects: Abortion, Spontaneous - genetics; Abortion, Spontaneous - metabolism; Adult; Bisulfite; DNA Methylation; Female; forkhead box P3; Forkhead protein; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Foxp3 protein; Gestational Age; Humans; Immunological tolerance; Karyotype; Miscarriage; Pregnancy; promoter methylation; Promoter Regions, Genetic; Protein expression; Proteins; Statistics; unexplained recurrent spontaneous abortion; promoter methylation; unexplained recurrent spontaneous abortion; forkhead box P3; protein expression

Aim The aim of this study was to investigate the level of Forkhead box P3 (FOXP3) promoter methylation and protein expression in recurrent spontaneous abortion and to elucidate the pathogenesis of unexplained recurrent spontaneous abortion (URSA). Methods We assessed a total of 56 URSA patients with...