Maternal glucocorticoid hormone influences nerve growth factor expression in the developing rat brain

• Published in: Neuroreport Vol. 12; no. 13; p. 2881
• Main Authors: Scaccianoce, S, Catalani, A, Lombardo, K, Consoli, C, Angelucci, L
• Format: Journal Article
• Language: English
• Published: England 17.09.2001
• Subjects: Animals; Animals, Suckling - anatomy & histology; Animals, Suckling - growth & development; Animals, Suckling - metabolism; Animals, Suckling - physiology; Brain - growth & development; Brain - metabolism; Female; Gene Expression Regulation, Developmental - physiology; Glucocorticoids - blood; Glucocorticoids - metabolism; Hippocampus - growth & development; Hippocampus - metabolism; Hypothalamo-Hypophyseal System - metabolism; Lactation - physiology; Male; Maternal Behavior - physiology; Nerve Growth Factor - metabolism; Prefrontal Cortex - growth & development; Prefrontal Cortex - metabolism; Rats; Rats, Wistar - anatomy & histology; Rats, Wistar - growth & development; Rats, Wistar - metabolism; Sex Characteristics; Stress, Physiological - metabolism; Stress, Physiological - physiopathology; Substantia Innominata - growth & development; Substantia Innominata - metabolism

Rat pups nursed from birth by mothers with increased plasma corticosterone show long-lasting biochemical and behavioral modifications. Here we have investigated nerve growth factor (NGF) concentrations in the basal forebrain, prefrontal cortex and hippocampus of both male and female offspring at 11...