Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects

• Published in: Pharmacotherapy Vol. 20; no. 7; p. 756
• Main Authors: Swan, S K, St Peter, J V, Lambrecht, L J, Hursting, M J
• Format: Journal Article
• Language: English
• Published: United States 01.07.2000
• Subjects: Adult; Anticoagulants - adverse effects; Anticoagulants - pharmacokinetics; Anticoagulants - pharmacology; Double-Blind Method; Half-Life; Heparin - adverse effects; Heparin - pharmacokinetics; Heparin - pharmacology; Humans; Infusions, Intravenous; Male; Partial Thromboplastin Time; Pipecolic Acids - adverse effects; Pipecolic Acids - pharmacokinetics; Pipecolic Acids - pharmacology; Whole Blood Coagulation Time

To evaluate and compare the relationship between dosage and coagulation parameters, as well as safety profiles, of ascending bolus and infusion dosages of argatroban versus heparin in three phase I studies. Two randomized, double-blind studies compared argatroban and heparin, and one open-label, dos...