Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID‐19 related cytokine storm

The coronavirus disease 2019 (COVID‐19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent findings suggest that severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the coronavirus pathogen that causes COVID‐19, could elicit a...

Full description

Saved in:
Bibliographic Details
Published inStem cells (Dayton, Ohio) Vol. 39; no. 6; pp. 707 - 722
Main Authors Song, Na, Wakimoto, Hiroaki, Rossignoli, Filippo, Bhere, Deepak, Ciccocioppo, Rachele, Chen, Kok‐Siong, Khalsa, Jasneet Kaur, Mastrolia, Ilenia, Samarelli, Anna Valeria, Dominici, Massimo, Shah, Khalid
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.06.2021
Oxford University Press
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent findings suggest that severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the coronavirus pathogen that causes COVID‐19, could elicit a cytokine storm that drives edema, dysfunction of the airway exchange, and acute respiratory distress syndrome in the lung, followed by acute cardiac injury and thromboembolic events leading to multiorgan failure and death. Mesenchymal stem cells (MSCs), owing to their powerful immunomodulatory abilities, have the potential to attenuate the cytokine storm and have therefore been proposed as a potential therapeutic approach for which several clinical trials are underway. Given that intravenous infusion of MSCs results in a significant trapping in the lung, MSC therapy could directly mitigate inflammation, protect alveolar epithelial cells, and reverse lung dysfunction by normalizing the pulmonary microenvironment and preventing pulmonary fibrosis. In this review, we present an overview and perspectives of the SARS‐CoV‐2 induced inflammatory dysfunction and the potential of MSC immunomodulation for the prevention and treatment of COVID‐19 related pulmonary disease. Potential mechanism of MSC action in COVID‐19 infected patients. SARS‐CoV‐2 enters cells through receptor‐mediated endocytosis via interactions with cell surface protein angiotensin‐converting enzyme II (ACE2) receptor with the assistance of transmembrane protease serine 2 (TMPRSS2) protease, thus triggering a complex immune response involved in T cells, dendritic cells, natural killer cells and macrophages. Engineering MSCs with immunomodulatory molecules enhance the efficacy of homing to damaged tissues or cells and attenuate the cytokine storm, ultimately improving patients' outcome.
AbstractList The coronavirus disease 2019 (COVID-19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent findings suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus pathogen that causes COVID-19, could elicit a cytokine storm that drives edema, dysfunction of the airway exchange, and acute respiratory distress syndrome in the lung, followed by acute cardiac injury and thromboembolic events leading to multiorgan failure and death. Mesenchymal stem cells (MSCs), owing to their powerful immunomodulatory abilities, have the potential to attenuate the cytokine storm and have therefore been proposed as a potential therapeutic approach for which several clinical trials are underway. Given that intravenous infusion of MSCs results in a significant trapping in the lung, MSC therapy could directly mitigate inflammation, protect alveolar epithelial cells, and reverse lung dysfunction by normalizing the pulmonary microenvironment and preventing pulmonary fibrosis. In this review, we present an overview and perspectives of the SARS-CoV-2 induced inflammatory dysfunction and the potential of MSC immunomodulation for the prevention and treatment of COVID-19 related pulmonary disease.
The coronavirus disease 2019 (COVID‐19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent findings suggest that severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the coronavirus pathogen that causes COVID‐19, could elicit a cytokine storm that drives edema, dysfunction of the airway exchange, and acute respiratory distress syndrome in the lung, followed by acute cardiac injury and thromboembolic events leading to multiorgan failure and death. Mesenchymal stem cells (MSCs), owing to their powerful immunomodulatory abilities, have the potential to attenuate the cytokine storm and have therefore been proposed as a potential therapeutic approach for which several clinical trials are underway. Given that intravenous infusion of MSCs results in a significant trapping in the lung, MSC therapy could directly mitigate inflammation, protect alveolar epithelial cells, and reverse lung dysfunction by normalizing the pulmonary microenvironment and preventing pulmonary fibrosis. In this review, we present an overview and perspectives of the SARS‐CoV‐2 induced inflammatory dysfunction and the potential of MSC immunomodulation for the prevention and treatment of COVID‐19 related pulmonary disease. Potential mechanism of MSC action in COVID‐19 infected patients. SARS‐CoV‐2 enters cells through receptor‐mediated endocytosis via interactions with cell surface protein angiotensin‐converting enzyme II (ACE2) receptor with the assistance of transmembrane protease serine 2 (TMPRSS2) protease, thus triggering a complex immune response involved in T cells, dendritic cells, natural killer cells and macrophages. Engineering MSCs with immunomodulatory molecules enhance the efficacy of homing to damaged tissues or cells and attenuate the cytokine storm, ultimately improving patients' outcome.
Author Shah, Khalid
Song, Na
Bhere, Deepak
Mastrolia, Ilenia
Khalsa, Jasneet Kaur
Rossignoli, Filippo
Samarelli, Anna Valeria
Wakimoto, Hiroaki
Ciccocioppo, Rachele
Dominici, Massimo
Chen, Kok‐Siong
AuthorAffiliation 6 Harvard Stem Cell Institute, Harvard University Cambridge Massachusetts USA
1 Center for Stem Cell Therapeutics and Imaging (CSTI) Harvard Medical School Boston Massachusetts USA
4 Gastroenterology Unit, Department of Medicine, A.O.U.I. Policlinico G.B. Rossi & University of Verona Verona Italy
3 Department of Neurosurgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA
2 Department of Neurosurgery, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA
5 Laboratory of Cellular Therapy, Department of Medical and Surgical Sciences University of Modena and Reggio Emilia Modena Italy
AuthorAffiliation_xml – name: 1 Center for Stem Cell Therapeutics and Imaging (CSTI) Harvard Medical School Boston Massachusetts USA
– name: 6 Harvard Stem Cell Institute, Harvard University Cambridge Massachusetts USA
– name: 4 Gastroenterology Unit, Department of Medicine, A.O.U.I. Policlinico G.B. Rossi & University of Verona Verona Italy
– name: 3 Department of Neurosurgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA
– name: 5 Laboratory of Cellular Therapy, Department of Medical and Surgical Sciences University of Modena and Reggio Emilia Modena Italy
– name: 2 Department of Neurosurgery, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA
Author_xml – sequence: 1
  givenname: Na
  surname: Song
  fullname: Song, Na
  organization: Harvard Medical School
– sequence: 2
  givenname: Hiroaki
  surname: Wakimoto
  fullname: Wakimoto, Hiroaki
  organization: Harvard Medical School
– sequence: 3
  givenname: Filippo
  surname: Rossignoli
  fullname: Rossignoli, Filippo
  organization: Harvard Medical School
– sequence: 4
  givenname: Deepak
  surname: Bhere
  fullname: Bhere, Deepak
  organization: Harvard Medical School
– sequence: 5
  givenname: Rachele
  surname: Ciccocioppo
  fullname: Ciccocioppo, Rachele
  organization: Gastroenterology Unit, Department of Medicine, A.O.U.I. Policlinico G.B. Rossi & University of Verona
– sequence: 6
  givenname: Kok‐Siong
  surname: Chen
  fullname: Chen, Kok‐Siong
  organization: Harvard Medical School
– sequence: 7
  givenname: Jasneet Kaur
  surname: Khalsa
  fullname: Khalsa, Jasneet Kaur
  organization: Harvard Medical School
– sequence: 8
  givenname: Ilenia
  surname: Mastrolia
  fullname: Mastrolia, Ilenia
  organization: University of Modena and Reggio Emilia
– sequence: 9
  givenname: Anna Valeria
  surname: Samarelli
  fullname: Samarelli, Anna Valeria
  organization: University of Modena and Reggio Emilia
– sequence: 10
  givenname: Massimo
  surname: Dominici
  fullname: Dominici, Massimo
  organization: University of Modena and Reggio Emilia
– sequence: 11
  givenname: Khalid
  orcidid: 0000-0002-5474-0974
  surname: Shah
  fullname: Shah, Khalid
  email: kshah@bwh.harvard.edu
  organization: Harvard Stem Cell Institute, Harvard University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33586320$$D View this record in MEDLINE/PubMed
BookMark eNp1kc1u1DAURi1URH9gwQsgS2xgkdaO7cRmgYSGAiO16oLC1nKcm9bFsQc7Ac2OR-AZeRIcplSAxMpXukdHn-93iPZCDIDQY0qOKSH1SZ5gPGZM8HvogAquKq6o3CszaZpKEKX20WHON4RQLqR8gPYLKxtWkwNkzyFDsNfb0Xi8eLAF77EbxznEMfazN5OL4QVeB7yZU57dhOOAbQxTit67cIVXFx_Xr398-04VTlBw6LHdTvGTC1CMMY0P0f3B-AyPbt8j9OHN6eXqXXV28Xa9enVWWS4Zr8zQCQGkk6phbd_TFlgL_UCMULQjkgmg0NcNZ7RVtmx7YTrbSCKl6SgDwY7Qy513M3cj9BZKRuP1JrnRpK2Oxum_N8Fd66v4RctymJo3RfDsVpDi5xnypEeXl3uYAHHOuuZSCSU5bwv69B_0Js4plO_pWjDKGRfNQj3fUTbFnBMMd2Eo0Ut1ejm5Xqor7JM_09-Rv7sqwMkO-Oo8bP9v0u8vT89_KX8CWp-n0g
CitedBy_id crossref_primary_10_32388_YKMEB3_2
crossref_primary_10_1177_09636897231184611
crossref_primary_10_1007_s11010_023_04785_1
crossref_primary_10_1186_s13287_021_02664_4
crossref_primary_10_3390_ijms241713469
crossref_primary_10_1109_TMBMC_2023_3296430
crossref_primary_10_1016_j_heliyon_2024_e29769
crossref_primary_10_3390_cells11142175
crossref_primary_10_1016_j_cryobiol_2024_104856
crossref_primary_10_2174_1574888X18666230103120302
crossref_primary_10_1007_s00210_023_02882_y
crossref_primary_10_3390_antibiotics10070750
crossref_primary_10_1007_s12020_024_03944_8
crossref_primary_10_1007_s11033_023_09174_x
crossref_primary_10_1055_a_1720_7975
crossref_primary_10_2217_imt_2021_0245
crossref_primary_10_3389_fcell_2022_836887
crossref_primary_10_1002_elsc_202100097
crossref_primary_10_3389_fimmu_2022_880523
crossref_primary_10_1002_ccr3_5851
crossref_primary_10_3389_fpubh_2022_967829
crossref_primary_10_3390_cells11172686
crossref_primary_10_1186_s13287_023_03286_8
crossref_primary_10_1016_j_jare_2024_05_004
crossref_primary_10_1093_stmcls_sxad011
crossref_primary_10_1016_j_intimp_2024_112255
crossref_primary_10_1016_j_intimp_2023_110890
crossref_primary_10_1016_j_ejphar_2023_176148
crossref_primary_10_3389_fcell_2021_675310
crossref_primary_10_3389_fcell_2022_1047094
crossref_primary_10_3390_ijms24043745
crossref_primary_10_2174_011574888X260032230925052240
crossref_primary_10_3390_ijms222212421
crossref_primary_10_1186_s13287_022_03181_8
crossref_primary_10_1016_j_addr_2023_115147
crossref_primary_10_1097_ANC_0000000000000954
crossref_primary_10_26685_urncst_319
crossref_primary_10_1016_j_intimp_2022_108655
crossref_primary_10_1128_cmr_00188_21
Cites_doi 10.1007/s00395-020-0791-5
10.1016/j.ijantimicag.2020.105954
10.1111/trf.13562
10.1186/1465-9921-11-147
10.1164/rccm.201206-0990OC
10.1007/s11684-020-0773-x
10.1016/S0140-6736(20)30183-5
10.1186/1471-2172-10-35
10.1038/ni.1637
10.1371/journal.pone.0085040
10.3389/fimmu.2018.02837
10.1002/stem.2619
10.1007/s00018-017-2473-5
10.1002/jcp.24794
10.1186/s12916-015-0426-0
10.5966/sctm.2013-0033
10.1164/rccm.201701-0170OC
10.1186/s13287-018-0802-8
10.1038/s41591-020-0901-9
10.14336/AD.2020.0228
10.1038/s41577-020-0331-4
10.1016/j.yexcr.2019.05.035
10.1016/j.reth.2020.03.012
10.1155/2018/9214831
10.1126/science.abc6141
10.1111/imm.13223
10.1002/jgh3.12141
10.1007/s10565-019-09493-5
10.3332/ecancer.2020.1023
10.1073/pnas.0704581104
10.1186/s12967-020-02339-3
10.1038/s41551-018-0325-8
10.1016/j.omtm.2019.05.004
10.1080/21645515.2015.1030549
10.3727/096368914X685087
10.1164/rccm.201701-0107CP
10.7150/thno.27576
10.5483/BMBRep.2020.53.8.121
10.1016/j.bbrc.2012.12.134
10.3390/cells9040924
10.1080/14712598.2020.1761322
10.1016/j.tcm.2015.12.001
10.1016/j.medidd.2020.100019
10.1016/S2213-2600(18)30418-1
10.1186/s12967-015-0700-0
10.1016/S0140-6736(20)30566-3
10.1128/JVI.79.14.9320-9324.2005
10.1097/MD.0000000000021429
10.1186/s13063-020-04416-w
10.1016/j.jcv.2020.104362
10.1183/13993003.00858-2020
10.1186/s13287-016-0395-z
10.1007/s00134-020-05991-x
10.1182/blood-2007-10-119370
10.4252/wjsc.v12.i9.1013
10.3389/fimmu.2017.00313
10.3184/003685010X12708191209250
10.1186/s13063-020-04380-5
10.1371/journal.ppat.1000604
10.1371/journal.pone.0233263
10.1016/j.transproceed.2017.03.078
10.1186/s40635-017-0155-0
10.1093/brain/awv094
10.1038/nm.2736
10.1002/sctm.20-0083
10.1186/s13287-018-0936-8
10.3389/fphar.2020.00857
10.1016/S0140-6736(20)30628-0
10.3906/sag-2004-168
10.1097/DCR.0000000000001700
10.1038/s41577-020-0308-3
10.1002/sctm.16-0415
10.1165/rcmb.2012-0406OC
10.1089/scd.2015.0120
10.1002/stem.2475
10.1016/j.clim.2020.108448
10.1080/08830185.2020.1756284
10.14336/AD.2020.0301
10.1016/j.ejphar.2019.01.022
10.5966/sctm.2015-0138
10.1148/radiol.2020200843
10.18632/oncotarget.7031
10.1016/j.molmed.2011.10.004
10.1016/j.jconrel.2020.06.036
10.1038/s41586-020-2179-y
10.1002/oby.22849
10.1016/S0301-472X(03)00110-3
10.3324/haematol.11446
10.1155/2016/5934782
10.3109/14653249.2010.507330
10.1126/science.abb8925
10.1016/j.bbamcr.2009.02.008
10.1002/sctm.18-0015
10.1038/leu.2014.273
10.1016/j.eng.2020.02.006
10.1093/infdis/jiy478
10.1080/14653240600855905
10.1164/rccm.201410-1765OC
10.1161/JAHA.120.016219
10.1073/pnas.1601911113
10.1093/cid/ciaa248
10.1021/acschemneuro.0c00346
10.1186/s41232-020-00121-y
10.3390/jcm8071025
10.1016/j.eclinm.2019.100249
10.1038/nbt.2816
10.1007/s12035-019-1554-x
10.1016/j.isci.2020.101303
10.1089/scd.2020.0080
10.1128/MMBR.05015-11
10.1002/sctm.19-0205
10.3892/mmr.2014.3025
ContentType Journal Article
Copyright AlphaMed Press 2021
AlphaMed Press 2021.
2021 AlphaMed Press
Copyright_xml – notice: AlphaMed Press 2021
– notice: AlphaMed Press 2021.
– notice: 2021 AlphaMed Press
DBID NPM
AAYXX
CITATION
7QO
7QP
7QR
7TK
7TM
8FD
FR3
K9.
P64
RC3
7X8
5PM
DOI 10.1002/stem.3354
DatabaseName PubMed
CrossRef
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Technology Research Database
Engineering Research Database
ProQuest Health & Medical Complete (Alumni)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
Genetics Abstracts
Biotechnology Research Abstracts
Technology Research Database
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
Chemoreception Abstracts
Engineering Research Database
Calcium & Calcified Tissue Abstracts
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList CrossRef
PubMed


Genetics Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Public Health
DocumentTitleAlternate MSC IMMUNOMODULATION AND COVID‐19
EISSN 1549-4918
EndPage 722
ExternalDocumentID 10_1002_stem_3354
33586320
STEM3354
Genre article
Journal Article
GrantInformation_xml – fundername: Departmental funds
GroupedDBID ---
.GJ
05W
0R~
123
18M
1OB
1OC
24P
2WC
31~
3WU
4.4
53G
5RE
5WD
8-0
8-1
A00
AABZA
AACZT
AAESR
AAIHA
AAONW
AAPGJ
AAPXW
AARHZ
AASNB
AAUAY
AAVAP
AAWDT
AAZKR
ABCUV
ABHFT
ABLJU
ABMNT
ABNHQ
ABPTD
ABXVV
ACFRR
ACGFO
ACGFS
ACIWK
ACPOU
ACPRK
ACUFI
ACUTJ
ACXQS
ACZBC
ADBBV
ADGKP
ADIPN
ADKYN
ADQBN
ADVEK
ADXAS
ADZMN
AENEX
AEUQT
AFBPY
AFFZL
AFGWE
AFRAH
AFYAG
AFZJQ
AGMDO
AHMBA
AIURR
AJAOE
AJEEA
ALMA_UNASSIGNED_HOLDINGS
AMYDB
APJGH
ATGXG
AVNTJ
AZBYB
AZVAB
BAWUL
BCRHZ
BEYMZ
BMXJE
BRXPI
CS3
DCZOG
DIK
DU5
E3Z
EBS
EJD
EMB
EMOBN
F5P
FD6
G-S
GODZA
GX1
H13
HHY
HZ~
IH2
KOP
KSI
KSN
LATKE
LEEKS
LH4
LITHE
LMP
LOXES
LUTES
LW6
LYRES
MY~
N9A
NNB
NOMLY
O66
O9-
OBOKY
OCZFY
OIG
OJZSN
OK1
OPAEJ
OVD
OWPYF
P2P
P2W
P4E
PALCI
PQQKQ
RAO
RIWAO
RJQFR
ROL
ROX
RWI
SUPJJ
SV3
TEORI
TMA
TR2
WBKPD
WOHZO
WOQ
WYB
WYJ
XV2
ZGI
ZXP
ZZTAW
~S-
NPM
AAYXX
ABEJV
AHMMS
CITATION
7QO
7QP
7QR
7TK
7TM
8FD
FR3
K9.
P64
RC3
7X8
5PM
ID FETCH-LOGICAL-c4834-afb55e0b89637dd17e37edf0a591b0835e1ed2643179c17ed5abc68088ab13e53
ISSN 1066-5099
IngestDate Tue Sep 17 20:59:06 EDT 2024
Wed Dec 04 11:05:49 EST 2024
Wed Dec 18 16:53:45 EST 2024
Fri Dec 06 05:25:13 EST 2024
Wed Oct 16 00:43:32 EDT 2024
Sat Aug 24 01:03:52 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords COVID-19
immunomodulation
coronavirus
SARS-CoV-2
cytokine storm
mesenchymal stem cells
Language English
License AlphaMed Press 2021.
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c4834-afb55e0b89637dd17e37edf0a591b0835e1ed2643179c17ed5abc68088ab13e53
Notes Funding information
Departmental funds
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Funding information Departmental funds
ORCID 0000-0002-5474-0974
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC8014246
PMID 33586320
PQID 2531434567
PQPubID 1046343
PageCount 16
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8014246
proquest_miscellaneous_2489598447
proquest_journals_2531434567
crossref_primary_10_1002_stem_3354
pubmed_primary_33586320
wiley_primary_10_1002_stem_3354_STEM3354
PublicationCentury 2000
PublicationDate June 2021
PublicationDateYYYYMMDD 2021-06-01
PublicationDate_xml – month: 06
  year: 2021
  text: June 2021
PublicationDecade 2020
PublicationPlace Hoboken, USA
PublicationPlace_xml – name: Hoboken, USA
– name: United States
– name: Oxford
PublicationTitle Stem cells (Dayton, Ohio)
PublicationTitleAlternate Stem Cells
PublicationYear 2021
Publisher John Wiley & Sons, Inc
Oxford University Press
Publisher_xml – name: John Wiley & Sons, Inc
– name: Oxford University Press
References 2010; 12
2017; 5
2010; 11
2017; 6
2007; 104
2017; 8
2013; 2
2020; 20
2020; 63
2017; 49
2019; 56
2020; 160
2019; 14
2008; 9
2020; 325
2020; 368
2020; 127
2020; 15
2020; 14
2012; 18
2016; 2016
2020; 12
2017; 196
2020; 11
2020; 55
2020; 99
2014; 28
2020; 19
2020; 18
2018; 7
2020; 6
2018; 9
2020; 5
2017; 74
2009; 10
2020; 53
2015; 138
2020; 50
2020; 296
2017; 35
2020; 9
2020; 215
2013; 431
2016; 113
2020; 46
2008; 112
2014; 9
2009; 1793
2005; 79
2015; 13
2019; 8
2019; 7
2019; 9
2019; 3
2013; 49
2020; 581
2020; 40
2015; 11
2020; 39
2006; 8
2007; 92
2020; 36
2020; 34
2013; 187
2019; 383
2012; 76
2003; 31
2016; 12
2016; 56
2015; 24
2016; 5
2016; 7
2018; 2018
2015; 192
2020
2020; 395
2020; 71
2015; 230
2020; 115
2020; 28
2015; 2015
2019; 852
2020; 26
2020; 23
2019; 219
2009; 5
2020; 21
2016; 26
2014; 32
2010; 93
2020; 29
Thompson (2022061709080694700_stem3354-bib-0053) 2020; 19
Liu (2022061709080694700_stem3354-bib-0002) 2020
Kirshner (2022061709080694700_stem3354-bib-0113) 2005; 79
Watanabe (2022061709080694700_stem3354-bib-0077) 2020; 14
Fu (2022061709080694700_stem3354-bib-0027) 2020; 18
Li (2022061709080694700_stem3354-bib-0093) 2016; 7
Monsel (2022061709080694700_stem3354-bib-0120) 2015; 192
Cao (2022061709080694700_stem3354-bib-0005) 2020; 20
Rizzo (2022061709080694700_stem3354-bib-0012) 2020; 115
Ciccocioppo (2022061709080694700_stem3354-bib-0067) 2019; 3
Bustos (2022061709080694700_stem3354-bib-0071) 2013; 2
Teoh (2022061709080694700_stem3354-bib-0032) 2020; 5
Dalberto (2022061709080694700_stem3354-bib-0039) 2010; 93
Felsenstein (2022061709080694700_stem3354-bib-0021) 2020; 215
Lopes-Pacheco (2022061709080694700_stem3354-bib-0078) 2020; 36
Huang (2022061709080694700_stem3354-bib-0004) 2020; 395
Reinders (2022061709080694700_stem3354-bib-0059) 2015; 13
Tang (2022061709080694700_stem3354-bib-0122) 2017; 35
Jayaramayya (2022061709080694700_stem3354-bib-0075) 2020; 53
Condor (2022061709080694700_stem3354-bib-0079) 2016; 5
Wang (2022061709080694700_stem3354-bib-0041) 2018; 2018
Mesoblast (2022061709080694700_stem3354-bib-0096) 2020
George (2022061709080694700_stem3354-bib-0083) 2018; 7
Netsch (2022061709080694700_stem3354-bib-0090) 2018; 9
Lee (2022061709080694700_stem3354-bib-0091) 2013; 187
Salvadori (2022061709080694700_stem3354-bib-0037) 2019; 14
Qin (2022061709080694700_stem3354-bib-0008) 2020; 71
Zhou (2022061709080694700_stem3354-bib-0017) 2020; 14
Morrison (2022061709080694700_stem3354-bib-0121) 2017; 196
Atluri (2022061709080694700_stem3354-bib-0010) 2020; 23
Yin (2022061709080694700_stem3354-bib-0042) 2019; 3
Ferreira (2022061709080694700_stem3354-bib-0048) 2018; 9
Johnson (2022061709080694700_stem3354-bib-0065) 2017; 6
Bari (2022061709080694700_stem3354-bib-0074) 2020; 9
Hashi (2022061709080694700_stem3354-bib-0089) 2007; 104
Zhang (2022061709080694700_stem3354-bib-0026) 2020; 55
Zhou (2022061709080694700_stem3354-bib-0081) 2020; 395
Lakdawala (2022061709080694700_stem3354-bib-0107) 2020; 368
Tsuchiya (2022061709080694700_stem3354-bib-0056) 2020; 40
Wu (2022061709080694700_stem3354-bib-0087) 2017; 49
Tufan (2022061709080694700_stem3354-bib-0020) 2020; 50
Khoury (2022061709080694700_stem3354-bib-0108) 2020; 55
Snelgrove (2022061709080694700_stem3354-bib-0038) 2008; 9
Ye (2022061709080694700_stem3354-bib-0098) 2020; 21
Liao (2022061709080694700_stem3354-bib-0018) 2020; 26
Leng (2022061709080694700_stem3354-bib-0099) 2020; 11
Conti (2022061709080694700_stem3354-bib-0022) 2020; 34
Zbinden-Foncea (2022061709080694700_stem3354-bib-0023) 2020; 28
Shetty (2022061709080694700_stem3354-bib-0100) 2020; 11
D'Souza (2022061709080694700_stem3354-bib-0036) 2015; 13
Ruan (2022061709080694700_stem3354-bib-0011) 2020; 46
Peteranderl (2022061709080694700_stem3354-bib-0112) 2017; 8
Martínez-Urbistondo (2022061709080694700_stem3354-bib-0031) 2020
Lightner (2022061709080694700_stem3354-bib-0103) 2020; 63
Temesgen (2022061709080694700_stem3354-bib-0030) 2020
Chen (2022061709080694700_stem3354-bib-0028) 2020; 6
Liu (2022061709080694700_stem3354-bib-0050) 2015; 2015
Gorman (2022061709080694700_stem3354-bib-0054) 2020; 21
Gebler (2022061709080694700_stem3354-bib-0046) 2012; 18
Muraca (2022061709080694700_stem3354-bib-0076) 2020; 325
Wang (2022061709080694700_stem3354-bib-0111) 2020; 296
Law (2022061709080694700_stem3354-bib-0114) 2009; 10
Giannis (2022061709080694700_stem3354-bib-0082) 2020; 127
Zhu (2022061709080694700_stem3354-bib-0119) 2017; 5
Golchin (2022061709080694700_stem3354-bib-0015) 2020
Giudice (2022061709080694700_stem3354-bib-0033) 2020; 11
Ji (2022061709080694700_stem3354-bib-0064) 2020; 9
Mehta (2022061709080694700_stem3354-bib-0009) 2020; 395
Abati (2022061709080694700_stem3354-bib-0068) 2019; 56
Hu (2022061709080694700_stem3354-bib-0070) 2020
Laffey (2022061709080694700_stem3354-bib-0109) 2017; 196
Tan (2022061709080694700_stem3354-bib-0126) 2020; 160
Moore (2022061709080694700_stem3354-bib-0001) 2020; 368
Yi (2022061709080694700_stem3354-bib-0124) 2019; 383
Li (2022061709080694700_stem3354-bib-0044) 2017; 74
Islam (2022061709080694700_stem3354-bib-0066) 2012; 18
He (2022061709080694700_stem3354-bib-0073) 2015; 24
Gentile (2022061709080694700_stem3354-bib-0104) 2020; 20
Shneider (2022061709080694700_stem3354-bib-0024) 2020; 39
Chan (2022061709080694700_stem3354-bib-0092) 2016; 113
Bagci-Onder (2022061709080694700_stem3354-bib-0117) 2015; 138
Altay (2022061709080694700_stem3354-bib-0034) 2020; 23
Min (2022061709080694700_stem3354-bib-0106) 2015; 11
Abraham (2022061709080694700_stem3354-bib-0045) 2020; 9
Li (2022061709080694700_stem3354-bib-0123) 2019; 852
Russell (2022061709080694700_stem3354-bib-0029) 2020; 14
Prockop (2022061709080694700_stem3354-bib-0061) 2010; 12
Martinez-Gonzalez (2022061709080694700_stem3354-bib-0072) 2013; 49
Klimczak (2022061709080694700_stem3354-bib-0095) 2020; 12
Zhou (2022061709080694700_stem3354-bib-0043) 2019; 8
Witkowski (2022061709080694700_stem3354-bib-0085) 2016; 26
Cilloniz (2022061709080694700_stem3354-bib-0013) 2009; 5
Kaczorowski (2022061709080694700_stem3354-bib-0116) 2016; 7
Silva (2022061709080694700_stem3354-bib-0049) 2018; 9
Wang (2022061709080694700_stem3354-bib-0110)
Shoji-Kawata (2022061709080694700_stem3354-bib-0115) 2009; 1793
Malcherek (2022061709080694700_stem3354-bib-0051) 2014; 28
Ruppert (2022061709080694700_stem3354-bib-0101) 2020; 15
Tisoncik (2022061709080694700_stem3354-bib-0006) 2012; 76
Karlsson (2022061709080694700_stem3354-bib-0052) 2008; 112
Sengupta (2022061709080694700_stem3354-bib-0055) 2020; 29
Orqueda (2022061709080694700_stem3354-bib-0062) 2016; 2016
de Windt (2022061709080694700_stem3354-bib-0069) 2017; 35
Mays (2022061709080694700_stem3354-bib-0097) 2016; 56
He (2022061709080694700_stem3354-bib-0105) 2015; 230
Lee (2022061709080694700_stem3354-bib-0014) 2010; 11
Dominici (2022061709080694700_stem3354-bib-0040) 2006; 8
Tatsumi (2022061709080694700_stem3354-bib-0086) 2013; 431
Ankrum (2022061709080694700_stem3354-bib-0060) 2014; 32
Moll (2022061709080694700_stem3354-bib-0084) 2015; 24
Rossignoli (2022061709080694700_stem3354-bib-0118) 2019; 9
Merad (2022061709080694700_stem3354-bib-0019) 2020; 20
Guo (2022061709080694700_stem3354-bib-0025) 2020; 9
Metcalfe (2022061709080694700_stem3354-bib-0016) 2020; 5
Moll (2022061709080694700_stem3354-bib-0088) 2014; 9
Wang (2022061709080694700_stem3354-bib-0047) 2016; 12
Le Blanc (2022061709080694700_stem3354-bib-0057) 2003; 31
Schafer (2022061709080694700_stem3354-bib-0063) 2020
Qin (2022061709080694700_stem3354-bib-0125) 2020; 71
Loy (2022061709080694700_stem3354-bib-0094) 2019; 219
Shang (2022061709080694700_stem3354-bib-0003) 2020; 581
Saad (2022061709080694700_stem3354-bib-0035) 2020
Matthay (2022061709080694700_stem3354-bib-0080) 2019; 7
Sundin (2022061709080694700_stem3354-bib-0058) 2007; 92
Ur (2022061709080694700_stem3354-bib-0007) 2020; 11
Liang (2022061709080694700_stem3354-bib-0102) 2020; 99
References_xml – volume: 215
  year: 2020
  article-title: COVID‐19: immunology and treatment options
  publication-title: Clin Immunol
– volume: 8
  start-page: 1025
  issue: 7
  year: 2019
  article-title: The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity
  publication-title: J Clin Med
– volume: 2
  start-page: 884
  issue: 11
  year: 2013
  end-page: 895
  article-title: Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)‐10 and IL‐1RN levels
  publication-title: Stem Cells Translational Medicine
– volume: 12
  start-page: 1013
  issue: 9
  year: 2020
  end-page: 1022
  article-title: Perspectives on mesenchymal stem/progenitor cells and their derivates as potential therapies for lung damage caused by COVID‐19
  publication-title: World J Stem Cells
– volume: 5
  start-page: 1048
  issue: 8
  year: 2016
  end-page: 1057
  article-title: Treatment with human Wharton's jelly‐derived mesenchymal stem cells attenuates sepsis‐induced kidney injury, liver injury, and endothelial dysfunction
  publication-title: Stem Cells Translational Medicine
– volume: 35
  start-page: 256
  issue: 1
  year: 2017
  end-page: 264
  article-title: Allogeneic mesenchymal stem cells stimulate cartilage regeneration and are safe for single‐stage cartilage repair in humans upon mixture with recycled autologous chondrons
  publication-title: Stem Cells
– volume: 5
  start-page: 38
  issue: 1
  year: 2017
  article-title: Whole blood microRNA markers are associated with acute respiratory distress syndrome
  publication-title: Intensive Care Med Exp
– volume: 24
  start-page: 1699
  issue: 9
  year: 2015
  end-page: 1715
  article-title: Mesenchymal stem cells overexpressing angiotensin‐converting enzyme 2 rescue lipopolysaccharide‐induced lung injury
  publication-title: Cell Transplant
– volume: 187
  start-page: 751
  issue: 7
  year: 2013
  end-page: 760
  article-title: Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria
  publication-title: Am J Respir Crit Care Med
– volume: 2015
  year: 2015
  article-title: Human umbilical cord mesenchymal stem cells inhibit the function of allogeneic activated Vγ9Vδ2 T lymphocytes in vitro
  publication-title: Biomed Res Int
– volume: 15
  issue: 5
  year: 2020
  article-title: Human adipose‐derived mesenchymal stem cells for acute and sub‐acute TBI
  publication-title: PLoS One
– volume: 49
  start-page: 552
  issue: 4
  year: 2013
  end-page: 562
  article-title: Human mesenchymal stem cells overexpressing the IL‐33 antagonist soluble IL‐1 receptor‐like‐1 attenuate endotoxin‐induced acute lung injury
  publication-title: Am J Respir Cell Mol Biol
– volume: 192
  start-page: 324
  issue: 3
  year: 2015
  end-page: 336
  article-title: Therapeutic effects of human mesenchymal stem cell‐derived microvesicles in severe pneumonia in mice
  publication-title: Am J Respir Crit Care Med
– volume: 8
  start-page: 313
  year: 2017
  article-title: The impact of the interferon/TNF‐related apoptosis‐inducing ligand signaling axis on disease progression in respiratory viral infection and beyond
  publication-title: Front Immunol
– volume: 35
  start-page: 1849
  issue: 7
  year: 2017
  end-page: 1859
  article-title: Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang‐1 mRNA
  publication-title: Stem Cells
– volume: 28
  start-page: 2388
  issue: 12
  year: 2014
  end-page: 2394
  article-title: Mesenchymal stromal cells inhibit proliferation of virus‐specific CD8(+) T cells
  publication-title: Leukemia
– volume: 11
  start-page: 216
  issue: 2
  year: 2020
  end-page: 228
  article-title: Transplantation of ACE2‐mesenchymal stem cells improves the outcome of patients with COVID‐19 pneumonia
  publication-title: Aging Dis
– volume: 9
  start-page: 28
  issue: 1
  year: 2020
  end-page: 38
  article-title: Mesenchymal stem cell‐derived extracellular vesicles for the treatment of acute respiratory distress syndrome
  publication-title: Stem Cells Translational Medicine
– volume: 115
  start-page: 31
  issue: 3
  year: 2020
  article-title: COVID‐19 in the heart and the lungs: could we “notch” the inflammatory storm?
  publication-title: Basic Res Cardiol
– volume: 9
  start-page: 2837
  year: 2018
  article-title: Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre‐conditioning
  publication-title: Front Immunol
– volume: 9
  start-page: 1074
  issue: 9
  year: 2008
  end-page: 1083
  article-title: A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
  publication-title: Nat Immunol
– volume: 11
  start-page: 147
  year: 2010
  article-title: Systems‐level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I‐like alveolar epithelial cells in vitro
  publication-title: Respir Res
– volume: 5
  start-page: 227
  issue: 5
  year: 2020
  end-page: 229
  article-title: Statins as early therapy to mitigate COVID‐19 (SARS‐CoV‐2)‐associated ARDS and cytokine storm syndrome ‐ time is of the essence
  publication-title: J Clin Transl Res
– volume: 127
  year: 2020
  article-title: Coagulation disorders in coronavirus infected patients: COVID‐19, SARS‐CoV‐1, MERS‐CoV and lessons from the past
  publication-title: J Clin Virol
– volume: 99
  issue: 31
  year: 2020
  article-title: Clinical remission of a critically ill COVID‐19 patient treated by human umbilical cord mesenchymal stem cells: a case report
  publication-title: Medicine
– volume: 18
  start-page: 128
  issue: 2
  year: 2012
  end-page: 134
  article-title: The immunomodulatory capacity of mesenchymal stem cells
  publication-title: Trends Mol Med
– volume: 9
  start-page: 45
  issue: 1
  year: 2018
  article-title: Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases
  publication-title: Stem Cell Res Ther
– volume: 325
  start-page: 135
  year: 2020
  end-page: 140
  article-title: Mesenchymal stromal cells and their secreted extracellular vesicles as therapeutic tools for COVID‐19 pneumonia?
  publication-title: J Control Release
– volume: 368
  start-page: 473
  year: 2020
  end-page: 474
  article-title: Cytokine release syndrome in severe COVID‐19
  publication-title: Science
– volume: 63
  start-page: 874
  year: 2020
  end-page: 878
  article-title: Mesenchymal stem cell therapy can transcend perianal Crohn's disease: how colorectal surgeons can help in the COVID‐19 crisis
  publication-title: Dis Colon Rectum
– volume: 14
  start-page: 1
  year: 2019
  end-page: 15
  article-title: Dissecting the pharmacodynamics and pharmacokinetics of MSCs to overcome limitations in their clinical translation
  publication-title: Mol Ther Methods Clin Dev
– year: 2020
  article-title: Treatment of critical limb ischemia with localized scleroderma by local injection of umbilical cord mesenchymal stem cells
  publication-title: Med Clin
– volume: 9
  start-page: 436
  issue: 2
  year: 2019
  end-page: 448
  article-title: MSC‐delivered soluble TRAIL and paclitaxel as novel combinatory treatment for pancreatic adenocarcinoma
  publication-title: Theranostics
– volume: 160
  start-page: 261
  issue: 3
  year: 2020
  end-page: 268
  article-title: Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China
  publication-title: Immunology
– volume: 14
  start-page: 1023
  year: 2020
  article-title: COVID‐19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting?
  publication-title: Ecancermedicalscience
– volume: 9
  start-page: 813
  year: 2020
  end-page: 814
  article-title: Mesenchymal stem cells as a potential treatment for critically ill patients with coronavirus disease 2019
  publication-title: Stem Cells Translational Medicine
– volume: 36
  start-page: 83
  issue: 1
  year: 2020
  end-page: 102
  article-title: Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome
  publication-title: Cell Biol Toxicol
– volume: 7
  start-page: 159
  issue: 1
  year: 2016
  article-title: Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus‐induced acute lung injury in mice
  publication-title: Stem Cell Res Ther
– start-page: 1
  year: 2020
  end-page: 7
  article-title: Mesenchymal stem cell therapy for COVID‐19: present or future
  publication-title: Stem Cell Rev Rep
– volume: 23
  issue: 7
  year: 2020
  article-title: Current status of COVID‐19 therapies and drug repositioning applications
  publication-title: iScience
– volume: 431
  start-page: 203
  issue: 2
  year: 2013
  end-page: 209
  article-title: Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism
  publication-title: Biochem Biophys Res Commun
– volume: 56
  start-page: 6703
  issue: 10
  year: 2019
  end-page: 6715
  article-title: Advances, challenges, and perspectives in translational stem cell therapy for amyotrophic lateral sclerosis
  publication-title: Mol Neurobiol
– volume: 34
  start-page: 327
  issue: 2
  year: 2020
  end-page: 331
  article-title: Induction of pro‐inflammatory cytokines (IL‐1 and IL‐6) and lung inflammation by Coronavirus‐19 (COVI‐19 or SARS‐CoV‐2): anti‐inflammatory strategies
  publication-title: J Biol Regul Homeost Agents
– volume: 53
  start-page: 400
  issue: 8
  year: 2020
  end-page: 412
  article-title: Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem‐cell‐derived exosomes for COVID‐19 treatment
  publication-title: BMB Rep
– volume: 196
  start-page: 1275
  issue: 10
  year: 2017
  end-page: 1286
  article-title: Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer
  publication-title: Am J Respir Crit Care Med
– volume: 230
  start-page: 691
  issue: 3
  year: 2015
  end-page: 701
  article-title: MSCs modified with ACE2 restore endothelial function following LPS challenge by inhibiting the activation of RAS
  publication-title: J Cell Physiol
– volume: 56
  start-page: 6S
  issue: 4
  year: 2016
  end-page: 8S
  article-title: Adult adherent cell therapy for ischemic stroke: clinical results and development experience using MultiStem
  publication-title: Transfusion
– volume: 9
  start-page: 184
  issue: 1
  year: 2018
  article-title: Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73‐converted adenosine
  publication-title: Stem Cell Res Ther
– volume: 10
  start-page: 35
  issue: 1
  year: 2009
  article-title: Toll‐like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
  publication-title: BMC Immunol
– volume: 40
  start-page: 14
  year: 2020
  article-title: Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID‐19) cases
  publication-title: Inflamm Regen
– volume: 12
  start-page: 85
  issue: 1
  year: 2016
  end-page: 96
  article-title: Comparative analysis of human mesenchymal stem cells from fetal‐bone marrow, adipose tissue, and Warton's jelly as sources of cell immunomodulatory therapy
  publication-title: Hum Vaccin Immunother
– volume: 28
  start-page: 1378
  year: 2020
  end-page: 1381
  article-title: Does high cardiorespiratory fitness confer some protection against proinflammatory responses after infection by SARS‐CoV‐2?
  publication-title: Obesity
– volume: 138
  start-page: 1710
  issue: pt 6
  year: 2015
  end-page: 1721
  article-title: Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells
  publication-title: Brain
– volume: 11
  start-page: 857
  year: 2020
  article-title: Combination of ruxolitinib and eculizumab for treatment of severe SARS‐CoV‐2‐related acute respiratory distress syndrome: a controlled study
  publication-title: Front Pharmacol
– volume: 20
  start-page: 269
  issue: 5
  year: 2020
  end-page: 270
  article-title: COVID‐19: immunopathology and its implications for therapy
  publication-title: Nat Rev Immunol
– volume: 581
  start-page: 221
  year: 2020
  end-page: 224
  article-title: Structural basis of receptor recognition by SARS‐CoV‐2
  publication-title: Nature
– volume: 2016
  year: 2016
  article-title: iPSCs: a minireview from bench to bed, including organoids and the CRISPR system
  publication-title: Stem Cells Int
– volume: 74
  start-page: 2345
  issue: 13
  year: 2017
  end-page: 2360
  article-title: Interactions between mesenchymal stem cells and the immune system
  publication-title: Cell Mol Life Sci
– volume: 20
  issue: 7
  year: 2020
  end-page: 716
  article-title: Adipose‐derived stromal stem cells (ASCs) as a new regenerative immediate therapy combating coronavirus (COVID‐19)‐induced pneumonia
  publication-title: Expert Opin Biol Ther
– volume: 2018
  start-page: 1
  year: 2018
  end-page: 12
  article-title: Mesenchymal stem cell‐based immunomodulation: properties and clinical application
  publication-title: Stem Cells Int
– volume: 39
  start-page: 153
  issue: 4
  year: 2020
  end-page: 162
  article-title: Can melatonin reduce the severity of COVID‐19 pandemic?
  publication-title: Int Rev Immunol
– volume: 12
  start-page: 576
  issue: 5
  year: 2010
  end-page: 578
  article-title: Defining the risks of mesenchymal stromal cell therapy
  publication-title: Cytotherapy
– volume: 26
  start-page: 297
  issue: 4
  year: 2016
  end-page: 303
  article-title: Tissue factor as a link between inflammation and coagulation
  publication-title: Trends Cardiovasc Med
– volume: 18
  start-page: 759
  issue: 5
  year: 2012
  end-page: 765
  article-title: Mitochondrial transfer from bone‐marrow‐derived stromal cells to pulmonary alveoli protects against acute lung injury
  publication-title: Nat Med
– volume: 71
  start-page: 762
  issue: 15
  year: 2020
  end-page: 768
  article-title: Dysregulation of immune response in patients with COVID‐19 in Wuhan, China
  publication-title: Clin Infect Dis
– volume: 112
  start-page: 532
  issue: 3
  year: 2008
  end-page: 541
  article-title: Mesenchymal stem cells exert differential effects on alloantigen and virus‐specific T‐cell responses
  publication-title: Blood
– year: 2020
  article-title: The science underlying COVID‐19: implications for the cardiovascular system
  publication-title: Circulation
– volume: 5
  issue: 10
  year: 2009
  article-title: Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes
  publication-title: PLoS Pathog
– volume: 14
  start-page: 117
  issue: 2
  year: 2020
  article-title: Advances in COVID‐19: the virus, the pathogenesis, and evidence‐based control and therapeutic strategies
  publication-title: Front Med
– volume: 29
  start-page: 747
  issue: 12
  year: 2020
  end-page: 754
  article-title: Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID‐19
  publication-title: Stem Cells Dev
– volume: 79
  start-page: 9320
  issue: 14
  year: 2005
  end-page: 9324
  article-title: Identification of TRAIL as an interferon regulatory factor 3 transcriptional target
  publication-title: J Virol
– volume: 71
  start-page: 762
  issue: 15
  year: 2020
  end-page: 768
  article-title: Dysregulation of immune response in patients with coronavirus 2019 (COVID‐19) in Wuhan, China
  publication-title: Clin Infect Dis
– volume: 219
  start-page: 186
  issue: 2
  year: 2019
  end-page: 196
  article-title: Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A(H5N1) virus‐associated acute lung injury
  publication-title: J Infect Dis
– volume: 11
  start-page: 2387
  issue: 4
  year: 2015
  end-page: 2396
  article-title: Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin‐converting enzyme 2 gene on bleomycin‐induced lung fibrosis injury
  publication-title: Mol Med Rep
– volume: 852
  start-page: 68
  year: 2019
  end-page: 76
  article-title: Mesenchymal stromal cells‐derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti‐apoptotic miR‐21‐5p
  publication-title: Eur J Pharmacol
– volume: 13
  start-page: 186
  year: 2015
  article-title: Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies
  publication-title: BMC Med
– volume: 9
  issue: 7
  year: 2020
  article-title: Coronavirus disease 2019 (COVID‐19) and cardiovascular disease: a viewpoint on the potential influence of angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers on onset and severity of severe acute respiratory syndrome coronavirus 2 infection
  publication-title: J Am Heart Assoc
– volume: 9
  start-page: 924
  issue: 4
  year: 2020
  article-title: Mesenchymal stromal cell secretome for severe COVID‐19 infections: premises for the therapeutic use
  publication-title: Cell
– volume: 3
  start-page: 249
  issue: 3
  year: 2019
  end-page: 260
  article-title: Systematic review with meta‐analysis: safety and efficacy of local injections of mesenchymal stem cells in perianal fistulas
  publication-title: JGH Open
– volume: 5
  year: 2020
  article-title: Mesenchymal stem cells and management of COVID‐19 pneumonia
  publication-title: Med Drug Discov
– volume: 24
  start-page: 2269
  issue: 19
  year: 2015
  end-page: 2279
  article-title: Different procoagulant activity of therapeutic mesenchymal stromal cells derived from bone marrow and placental decidua
  publication-title: Stem Cells Dev
– volume: 49
  start-page: 1656
  issue: 7
  year: 2017
  end-page: 1658
  article-title: Thromboembolism induced by umbilical cord mesenchymal stem cell infusion: a report of two cases and literature review
  publication-title: Transplant Proc
– volume: 383
  issue: 2
  year: 2019
  article-title: Exosomes derived from microRNA‐30b‐3p‐overexpressing mesenchymal stem cells protect against lipopolysaccharide‐induced acute lung injury by inhibiting SAA3
  publication-title: Exp Cell Res
– volume: 20
  start-page: 355
  issue: 6
  year: 2020
  end-page: 362
  article-title: Pathological inflammation in patients with COVID‐19: a key role for monocytes and macrophages
  publication-title: Nat Rev Immunol
– volume: 368
  start-page: 942
  issue: 6494
  year: 2020
  end-page: 943
  article-title: The search for a COVID‐19 animal model
  publication-title: Science
– volume: 23
  start-page: E71
  year: 2020
  end-page: E83
  article-title: Expanded umbilical cord mesenchymal stem cells (UC‐MSCs) as a therapeutic strategy in managing critically ill COVID‐19 patients: the case for compassionate use
  publication-title: Pain Physician
– volume: 46
  start-page: 846
  issue: 5
  year: 2020
  end-page: 848
  article-title: Clinical predictors of mortality due to COVID‐19 based on an analysis of data of 150 patients from Wuhan, China
  publication-title: Intensive Care Med
– volume: 196
  start-page: 266
  issue: 3
  year: 2017
  end-page: 273
  article-title: Fifty years of research in ARDS. Cell‐based therapy for acute respiratory distress syndrome. Biology and potential therapeutic value
  publication-title: Am J Respir Crit Care Med
– volume: 32
  start-page: 252
  issue: 3
  year: 2014
  end-page: 260
  article-title: Mesenchymal stem cells: immune evasive, not immune privileged
  publication-title: Nat Biotechnol
– volume: 13
  start-page: 344
  year: 2015
  article-title: Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study
  publication-title: J Transl Med
– volume: 6
  start-page: 1153
  year: 2020
  end-page: 1161
  article-title: Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic influenza A (H7N9) infection, a hint for COVID‐19 treatment
  publication-title: Engineering
– volume: 55
  year: 2020
  article-title: Current status of cell‐based therapies for respiratory virus infections: applicability to COVID‐19
  publication-title: Eur Respir J
– volume: 7
  start-page: 9046
  issue: 8
  year: 2016
  end-page: 9059
  article-title: Delivery of improved oncolytic adenoviruses by mesenchymal stromal cells for elimination of tumorigenic pancreatic cancer cells
  publication-title: Oncotarget
– year: 2020
  article-title: Human mesenchymal stromal cells are resistant to SARS‐CoV‐2 infection under steady‐state, inflammatory conditions and in the presence of SARS‐CoV‐2‐infected cells
  publication-title: Stem Cell Reports
– volume: 8
  start-page: 315
  issue: 4
  year: 2006
  end-page: 317
  article-title: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
  publication-title: Cytotherapy
– volume: 19
  year: 2020
  article-title: Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: an updated systematic review and meta‐analysis
  publication-title: EClinicalMedicine
– volume: 92
  start-page: 1208
  issue: 9
  year: 2007
  end-page: 1215
  article-title: No alloantibodies against mesenchymal stromal cells, but presence of anti‐fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
  publication-title: Haematologica
– volume: 93
  start-page: 129
  issue: 2
  year: 2010
  end-page: 140
  article-title: Mesenchymal stem cells as a platform for gene therapy protocols
  publication-title: Sci Prog
– volume: 9
  issue: 1
  year: 2014
  article-title: Do ABO blood group antigens hamper the therapeutic efficacy of mesenchymal stromal cells?
  publication-title: PLoS One
– volume: 18
  start-page: 1
  issue: 1
  year: 2020
  end-page: 5
  article-title: Why tocilizumab could be an effective treatment for severe COVID‐19?
  publication-title: J Transl Med
– volume: 1793
  start-page: 1478
  issue: 9
  year: 2009
  end-page: 1484
  article-title: Autophagy, antiviral immunity, and viral countermeasures
  publication-title: Biochim Biophys Acta
– volume: 395
  start-page: 1033
  issue: 10229
  year: 2020
  end-page: 1034
  article-title: COVID‐19: consider cytokine storm syndromes and immunosuppression
  publication-title: Lancet
– year: 2020
  article-title: Early combination of tocilizumab and corticosteroids: an upgrade in anti‐inflammatory therapy for severe COVID
  publication-title: Clin Infect Dis
– volume: 6
  start-page: 1141
  issue: 4
  year: 2017
  end-page: 1151
  article-title: Concise review: mesenchymal stromal cell‐based approaches for the treatment of acute respiratory distress and sepsis syndromes
  publication-title: Stem Cells Translational Medicine
– volume: 76
  start-page: 16
  issue: 1
  year: 2012
  end-page: 32
  article-title: Into the eye of the cytokine storm
  publication-title: Microbiol Mol Biol Rev
– volume: 50
  start-page: 620
  issue: SI‐1
  year: 2020
  end-page: 632
  article-title: COVID‐19, immune system response, hyperinflammation and repurposing antirheumatic drugs
  publication-title: Turk J Med Sci
– volume: 21
  start-page: 462
  issue: 1
  year: 2020
  article-title: Repair of acute respiratory distress syndrome by stromal cell administration in COVID‐19 (REALIST‐COVID‐19): a structured summary of a study protocol for a randomised, controlled trial
  publication-title: Trials
– volume: 31
  start-page: 890
  issue: 10
  year: 2003
  end-page: 896
  article-title: HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
  publication-title: Exp Hematol
– volume: 113
  start-page: 3621
  issue: 13
  year: 2016
  end-page: 3626
  article-title: Human mesenchymal stromal cells reduce influenza A H5N1‐associated acute lung injury in vitro and in vivo
  publication-title: Proc Natl Acad Sci USA
– volume: 3
  start-page: 90
  issue: 2
  year: 2019
  end-page: 104
  article-title: Manufacturing of primed mesenchymal stromal cells for therapy
  publication-title: Nat Biomed Eng
– volume: 296
  start-page: E55
  issue: 2
  year: 2020
  end-page: E64
  article-title: Temporal changes of CT findings in 90 patients with COVID‐19 pneumonia: a longitudinal study
  publication-title: Radiology
– volume: 11
  start-page: 462
  issue: 2
  year: 2020
  end-page: 464
  article-title: Mesenchymal stem cell infusion shows promise for combating coronavirus (COVID‐19)‐induced pneumonia
  publication-title: Aging Dis
– volume: 395
  start-page: 497
  issue: 10223
  year: 2020
  end-page: 506
  article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
  publication-title: Lancet
– year: 2020
– volume: 395
  start-page: 1054
  issue: 10229
  year: 2020
  end-page: 1062
  article-title: Clinical course and risk factors for mortality of adult inpatients with COVID‐19 in Wuhan, China: a retrospective cohort study
  publication-title: Lancet
– volume: 26
  start-page: 842
  issue: 6
  year: 2020
  end-page: 844
  article-title: Single‐cell landscape of bronchoalveolar immune cells in patients with COVID‐19
  publication-title: Nat Med
– volume: 14
  start-page: 252
  year: 2020
  end-page: 261
  article-title: Development of a non‐alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles
  publication-title: Regen Ther
– volume: 104
  start-page: 11915
  issue: 29
  year: 2007
  end-page: 11920
  article-title: Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts
  publication-title: Proc Natl Acad Sci USA
– volume: 21
  start-page: 520
  issue: 1
  year: 2020
  article-title: Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID‐19: structured summary of a study protocol for a randomized controlled trial (phase I/II)
  publication-title: Trials
– volume: 55
  year: 2020
  article-title: The cytokine release syndrome (CRS) of severe COVID‐19 and Interleukin‐6 receptor (IL‐6R) antagonist tocilizumab may be the key to reduce the mortality
  publication-title: Int J Antimicrob Agents
– volume: 7
  start-page: 154
  issue: 2
  year: 2019
  end-page: 162
  article-title: Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial
  publication-title: Lancet Respir Med
– volume: 11
  start-page: 1868
  issue: 13
  year: 2020
  end-page: 1870
  article-title: Cytokine storm in COVID19: a neural hypothesis
  publication-title: ACS Chem Nerosci
– volume: 7
  start-page: 731
  issue: 10
  year: 2018
  end-page: 739
  article-title: Clinical cellular therapeutics accelerate clot formation
  publication-title: Stem Cells Translational Medicine
– volume: 115
  start-page: 31
  issue: 3
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0012
  article-title: COVID-19 in the heart and the lungs: could we “notch” the inflammatory storm?
  publication-title: Basic Res Cardiol
  doi: 10.1007/s00395-020-0791-5
  contributor:
    fullname: Rizzo
– volume-title: StatPearls
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0035
  contributor:
    fullname: Saad
– volume: 55
  start-page: 105954
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0026
  article-title: The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist tocilizumab may be the key to reduce the mortality
  publication-title: Int J Antimicrob Agents
  doi: 10.1016/j.ijantimicag.2020.105954
  contributor:
    fullname: Zhang
– volume: 56
  start-page: 6S
  issue: 4
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0097
  article-title: Adult adherent cell therapy for ischemic stroke: clinical results and development experience using MultiStem
  publication-title: Transfusion
  doi: 10.1111/trf.13562
  contributor:
    fullname: Mays
– volume: 11
  start-page: 147
  year: 2010
  ident: 2022061709080694700_stem3354-bib-0014
  article-title: Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
  publication-title: Respir Res
  doi: 10.1186/1465-9921-11-147
  contributor:
    fullname: Lee
– volume: 187
  start-page: 751
  issue: 7
  year: 2013
  ident: 2022061709080694700_stem3354-bib-0091
  article-title: Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201206-0990OC
  contributor:
    fullname: Lee
– volume: 14
  start-page: 117
  issue: 2
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0017
  article-title: Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies
  publication-title: Front Med
  doi: 10.1007/s11684-020-0773-x
  contributor:
    fullname: Zhou
– volume: 395
  start-page: 497
  issue: 10223
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0004
  article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30183-5
  contributor:
    fullname: Huang
– volume: 10
  start-page: 35
  issue: 1
  year: 2009
  ident: 2022061709080694700_stem3354-bib-0114
  article-title: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
  publication-title: BMC Immunol
  doi: 10.1186/1471-2172-10-35
  contributor:
    fullname: Law
– volume: 23
  start-page: E71
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0010
  article-title: Expanded umbilical cord mesenchymal stem cells (UC-MSCs) as a therapeutic strategy in managing critically ill COVID-19 patients: the case for compassionate use
  publication-title: Pain Physician
  contributor:
    fullname: Atluri
– volume: 9
  start-page: 1074
  issue: 9
  year: 2008
  ident: 2022061709080694700_stem3354-bib-0038
  article-title: A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
  publication-title: Nat Immunol
  doi: 10.1038/ni.1637
  contributor:
    fullname: Snelgrove
– start-page: 1
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0015
  article-title: Mesenchymal stem cell therapy for COVID-19: present or future
  publication-title: Stem Cell Rev Rep
  contributor:
    fullname: Golchin
– volume: 9
  start-page: e85040
  issue: 1
  year: 2014
  ident: 2022061709080694700_stem3354-bib-0088
  article-title: Do ABO blood group antigens hamper the therapeutic efficacy of mesenchymal stromal cells?
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0085040
  contributor:
    fullname: Moll
– volume: 9
  start-page: 2837
  year: 2018
  ident: 2022061709080694700_stem3354-bib-0048
  article-title: Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.02837
  contributor:
    fullname: Ferreira
– volume: 35
  start-page: 1849
  issue: 7
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0122
  article-title: Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang-1 mRNA
  publication-title: Stem Cells
  doi: 10.1002/stem.2619
  contributor:
    fullname: Tang
– volume: 74
  start-page: 2345
  issue: 13
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0044
  article-title: Interactions between mesenchymal stem cells and the immune system
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-017-2473-5
  contributor:
    fullname: Li
– volume: 230
  start-page: 691
  issue: 3
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0105
  article-title: MSCs modified with ACE2 restore endothelial function following LPS challenge by inhibiting the activation of RAS
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.24794
  contributor:
    fullname: He
– volume: 13
  start-page: 186
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0036
  article-title: Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies
  publication-title: BMC Med
  doi: 10.1186/s12916-015-0426-0
  contributor:
    fullname: D'Souza
– volume: 2
  start-page: 884
  issue: 11
  year: 2013
  ident: 2022061709080694700_stem3354-bib-0071
  article-title: Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)-10 and IL-1RN levels
  publication-title: Stem Cells Translational Medicine
  doi: 10.5966/sctm.2013-0033
  contributor:
    fullname: Bustos
– volume: 196
  start-page: 1275
  issue: 10
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0121
  article-title: Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201701-0170OC
  contributor:
    fullname: Morrison
– volume: 9
  start-page: 45
  issue: 1
  year: 2018
  ident: 2022061709080694700_stem3354-bib-0049
  article-title: Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-018-0802-8
  contributor:
    fullname: Silva
– volume: 26
  start-page: 842
  issue: 6
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0018
  article-title: Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0901-9
  contributor:
    fullname: Liao
– volume: 11
  start-page: 216
  issue: 2
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0099
  article-title: Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia
  publication-title: Aging Dis
  doi: 10.14336/AD.2020.0228
  contributor:
    fullname: Leng
– volume: 20
  start-page: 355
  issue: 6
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0019
  article-title: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-020-0331-4
  contributor:
    fullname: Merad
– volume: 383
  start-page: 111454
  issue: 2
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0124
  article-title: Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2019.05.035
  contributor:
    fullname: Yi
– volume: 14
  start-page: 252
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0077
  article-title: Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles
  publication-title: Regen Ther
  doi: 10.1016/j.reth.2020.03.012
  contributor:
    fullname: Watanabe
– volume: 2018
  start-page: 1
  year: 2018
  ident: 2022061709080694700_stem3354-bib-0041
  article-title: Mesenchymal stem cell-based immunomodulation: properties and clinical application
  publication-title: Stem Cells Int
  doi: 10.1155/2018/9214831
  contributor:
    fullname: Wang
– volume: 368
  start-page: 942
  issue: 6494
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0107
  article-title: The search for a COVID-19 animal model
  publication-title: Science
  doi: 10.1126/science.abc6141
  contributor:
    fullname: Lakdawala
– volume: 160
  start-page: 261
  issue: 3
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0126
  article-title: Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China
  publication-title: Immunology
  doi: 10.1111/imm.13223
  contributor:
    fullname: Tan
– volume: 3
  start-page: 249
  issue: 3
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0067
  article-title: Systematic review with meta-analysis: safety and efficacy of local injections of mesenchymal stem cells in perianal fistulas
  publication-title: JGH Open
  doi: 10.1002/jgh3.12141
  contributor:
    fullname: Ciccocioppo
– volume: 36
  start-page: 83
  issue: 1
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0078
  article-title: Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome
  publication-title: Cell Biol Toxicol
  doi: 10.1007/s10565-019-09493-5
  contributor:
    fullname: Lopes-Pacheco
– volume: 14
  start-page: 1023
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0029
  article-title: COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting?
  publication-title: Ecancermedicalscience
  doi: 10.3332/ecancer.2020.1023
  contributor:
    fullname: Russell
– volume: 104
  start-page: 11915
  issue: 29
  year: 2007
  ident: 2022061709080694700_stem3354-bib-0089
  article-title: Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0704581104
  contributor:
    fullname: Hashi
– volume: 18
  start-page: 1
  issue: 1
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0027
  article-title: Why tocilizumab could be an effective treatment for severe COVID-19?
  publication-title: J Transl Med
  doi: 10.1186/s12967-020-02339-3
  contributor:
    fullname: Fu
– volume: 3
  start-page: 90
  issue: 2
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0042
  article-title: Manufacturing of primed mesenchymal stromal cells for therapy
  publication-title: Nat Biomed Eng
  doi: 10.1038/s41551-018-0325-8
  contributor:
    fullname: Yin
– volume: 14
  start-page: 1
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0037
  article-title: Dissecting the pharmacodynamics and pharmacokinetics of MSCs to overcome limitations in their clinical translation
  publication-title: Mol Ther Methods Clin Dev
  doi: 10.1016/j.omtm.2019.05.004
  contributor:
    fullname: Salvadori
– volume: 12
  start-page: 85
  issue: 1
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0047
  article-title: Comparative analysis of human mesenchymal stem cells from fetal-bone marrow, adipose tissue, and Warton's jelly as sources of cell immunomodulatory therapy
  publication-title: Hum Vaccin Immunother
  doi: 10.1080/21645515.2015.1030549
  contributor:
    fullname: Wang
– volume-title: First clinical use of lenzilumab to neutralize GM-CSF in patients with severe COVID-19 pneumonia. medRxiv
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0030
  contributor:
    fullname: Temesgen
– volume: 24
  start-page: 1699
  issue: 9
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0073
  article-title: Mesenchymal stem cells overexpressing angiotensin-converting enzyme 2 rescue lipopolysaccharide-induced lung injury
  publication-title: Cell Transplant
  doi: 10.3727/096368914X685087
  contributor:
    fullname: He
– volume: 196
  start-page: 266
  issue: 3
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0109
  article-title: Fifty years of research in ARDS. Cell-based therapy for acute respiratory distress syndrome. Biology and potential therapeutic value
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201701-0107CP
  contributor:
    fullname: Laffey
– volume: 9
  start-page: 436
  issue: 2
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0118
  article-title: MSC-delivered soluble TRAIL and paclitaxel as novel combinatory treatment for pancreatic adenocarcinoma
  publication-title: Theranostics
  doi: 10.7150/thno.27576
  contributor:
    fullname: Rossignoli
– volume: 53
  start-page: 400
  issue: 8
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0075
  article-title: Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment
  publication-title: BMB Rep
  doi: 10.5483/BMBRep.2020.53.8.121
  contributor:
    fullname: Jayaramayya
– volume: 431
  start-page: 203
  issue: 2
  year: 2013
  ident: 2022061709080694700_stem3354-bib-0086
  article-title: Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2012.12.134
  contributor:
    fullname: Tatsumi
– year: 2020
  ident: 2022061709080694700_stem3354-bib-0031
  article-title: Early combination of tocilizumab and corticosteroids: an upgrade in anti-inflammatory therapy for severe COVID
  publication-title: Clin Infect Dis
  contributor:
    fullname: Martínez-Urbistondo
– volume: 9
  start-page: 924
  issue: 4
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0074
  article-title: Mesenchymal stromal cell secretome for severe COVID-19 infections: premises for the therapeutic use
  publication-title: Cell
  doi: 10.3390/cells9040924
  contributor:
    fullname: Bari
– volume: 20
  issue: 7
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0104
  article-title: Adipose-derived stromal stem cells (ASCs) as a new regenerative immediate therapy combating coronavirus (COVID-19)-induced pneumonia
  publication-title: Expert Opin Biol Ther
  doi: 10.1080/14712598.2020.1761322
  contributor:
    fullname: Gentile
– volume: 26
  start-page: 297
  issue: 4
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0085
  article-title: Tissue factor as a link between inflammation and coagulation
  publication-title: Trends Cardiovasc Med
  doi: 10.1016/j.tcm.2015.12.001
  contributor:
    fullname: Witkowski
– volume: 5
  start-page: 100019
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0016
  article-title: Mesenchymal stem cells and management of COVID-19 pneumonia
  publication-title: Med Drug Discov
  doi: 10.1016/j.medidd.2020.100019
  contributor:
    fullname: Metcalfe
– volume: 7
  start-page: 154
  issue: 2
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0080
  article-title: Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(18)30418-1
  contributor:
    fullname: Matthay
– volume: 13
  start-page: 344
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0059
  article-title: Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study
  publication-title: J Transl Med
  doi: 10.1186/s12967-015-0700-0
  contributor:
    fullname: Reinders
– volume-title: 83% Survival in COVID-19 Patients with Moderate/Severe Acute Respiratory Distress Syndrome Treated in New York with Mesoblast's Cell Therapy Remestemcel-L
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0096
  contributor:
    fullname: Mesoblast
– volume: 395
  start-page: 1054
  issue: 10229
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0081
  article-title: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30566-3
  contributor:
    fullname: Zhou
– volume: 79
  start-page: 9320
  issue: 14
  year: 2005
  ident: 2022061709080694700_stem3354-bib-0113
  article-title: Identification of TRAIL as an interferon regulatory factor 3 transcriptional target
  publication-title: J Virol
  doi: 10.1128/JVI.79.14.9320-9324.2005
  contributor:
    fullname: Kirshner
– volume: 99
  start-page: e21429
  issue: 31
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0102
  article-title: Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: a case report
  publication-title: Medicine
  doi: 10.1097/MD.0000000000021429
  contributor:
    fullname: Liang
– volume: 2015
  start-page: 317801
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0050
  article-title: Human umbilical cord mesenchymal stem cells inhibit the function of allogeneic activated Vγ9Vδ2 T lymphocytes in vitro
  publication-title: Biomed Res Int
  contributor:
    fullname: Liu
– volume: 21
  start-page: 462
  issue: 1
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0054
  article-title: Repair of acute respiratory distress syndrome by stromal cell administration in COVID-19 (REALIST-COVID-19): a structured summary of a study protocol for a randomised, controlled trial
  publication-title: Trials
  doi: 10.1186/s13063-020-04416-w
  contributor:
    fullname: Gorman
– volume: 127
  start-page: 104362
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0082
  article-title: Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2020.104362
  contributor:
    fullname: Giannis
– volume: 55
  start-page: 2000858
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0108
  article-title: Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19
  publication-title: Eur Respir J
  doi: 10.1183/13993003.00858-2020
  contributor:
    fullname: Khoury
– volume: 7
  start-page: 159
  issue: 1
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0093
  article-title: Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-016-0395-z
  contributor:
    fullname: Li
– year: 2020
  ident: 2022061709080694700_stem3354-bib-0063
  article-title: Human mesenchymal stromal cells are resistant to SARS-CoV-2 infection under steady-state, inflammatory conditions and in the presence of SARS-CoV-2-infected cells
  publication-title: Stem Cell Reports
  contributor:
    fullname: Schafer
– year: 2020
  ident: 2022061709080694700_stem3354-bib-0070
  article-title: Treatment of critical limb ischemia with localized scleroderma by local injection of umbilical cord mesenchymal stem cells
  publication-title: Med Clin
  contributor:
    fullname: Hu
– volume: 46
  start-page: 846
  issue: 5
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0011
  article-title: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China
  publication-title: Intensive Care Med
  doi: 10.1007/s00134-020-05991-x
  contributor:
    fullname: Ruan
– volume: 112
  start-page: 532
  issue: 3
  year: 2008
  ident: 2022061709080694700_stem3354-bib-0052
  article-title: Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses
  publication-title: Blood
  doi: 10.1182/blood-2007-10-119370
  contributor:
    fullname: Karlsson
– volume: 12
  start-page: 1013
  issue: 9
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0095
  article-title: Perspectives on mesenchymal stem/progenitor cells and their derivates as potential therapies for lung damage caused by COVID-19
  publication-title: World J Stem Cells
  doi: 10.4252/wjsc.v12.i9.1013
  contributor:
    fullname: Klimczak
– volume: 8
  start-page: 313
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0112
  article-title: The impact of the interferon/TNF-related apoptosis-inducing ligand signaling axis on disease progression in respiratory viral infection and beyond
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00313
  contributor:
    fullname: Peteranderl
– volume: 93
  start-page: 129
  issue: 2
  year: 2010
  ident: 2022061709080694700_stem3354-bib-0039
  article-title: Mesenchymal stem cells as a platform for gene therapy protocols
  publication-title: Sci Prog
  doi: 10.3184/003685010X12708191209250
  contributor:
    fullname: Dalberto
– volume: 21
  start-page: 520
  issue: 1
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0098
  article-title: Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (phase I/II)
  publication-title: Trials
  doi: 10.1186/s13063-020-04380-5
  contributor:
    fullname: Ye
– volume: 5
  start-page: e1000604
  issue: 10
  year: 2009
  ident: 2022061709080694700_stem3354-bib-0013
  article-title: Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1000604
  contributor:
    fullname: Cilloniz
– volume: 15
  start-page: e0233263
  issue: 5
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0101
  article-title: Human adipose-derived mesenchymal stem cells for acute and sub-acute TBI
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0233263
  contributor:
    fullname: Ruppert
– volume: 49
  start-page: 1656
  issue: 7
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0087
  article-title: Thromboembolism induced by umbilical cord mesenchymal stem cell infusion: a report of two cases and literature review
  publication-title: Transplant Proc
  doi: 10.1016/j.transproceed.2017.03.078
  contributor:
    fullname: Wu
– volume: 5
  start-page: 38
  issue: 1
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0119
  article-title: Whole blood microRNA markers are associated with acute respiratory distress syndrome
  publication-title: Intensive Care Med Exp
  doi: 10.1186/s40635-017-0155-0
  contributor:
    fullname: Zhu
– volume: 138
  start-page: 1710
  issue: pt 6
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0117
  article-title: Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells
  publication-title: Brain
  doi: 10.1093/brain/awv094
  contributor:
    fullname: Bagci-Onder
– volume: 18
  start-page: 759
  issue: 5
  year: 2012
  ident: 2022061709080694700_stem3354-bib-0066
  article-title: Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury
  publication-title: Nat Med
  doi: 10.1038/nm.2736
  contributor:
    fullname: Islam
– volume: 9
  start-page: 813
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0064
  article-title: Mesenchymal stem cells as a potential treatment for critically ill patients with coronavirus disease 2019
  publication-title: Stem Cells Translational Medicine
  doi: 10.1002/sctm.20-0083
  contributor:
    fullname: Ji
– volume: 9
  start-page: 184
  issue: 1
  year: 2018
  ident: 2022061709080694700_stem3354-bib-0090
  article-title: Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-018-0936-8
  contributor:
    fullname: Netsch
– volume: 11
  start-page: 857
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0033
  article-title: Combination of ruxolitinib and eculizumab for treatment of severe SARS-CoV-2-related acute respiratory distress syndrome: a controlled study
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2020.00857
  contributor:
    fullname: Giudice
– volume: 395
  start-page: 1033
  issue: 10229
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0009
  article-title: COVID-19: consider cytokine storm syndromes and immunosuppression
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30628-0
  contributor:
    fullname: Mehta
– volume: 50
  start-page: 620
  issue: SI-1
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0020
  article-title: COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs
  publication-title: Turk J Med Sci
  doi: 10.3906/sag-2004-168
  contributor:
    fullname: Tufan
– volume: 63
  start-page: 874
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0103
  article-title: Mesenchymal stem cell therapy can transcend perianal Crohn's disease: how colorectal surgeons can help in the COVID-19 crisis
  publication-title: Dis Colon Rectum
  doi: 10.1097/DCR.0000000000001700
  contributor:
    fullname: Lightner
– volume: 20
  start-page: 269
  issue: 5
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0005
  article-title: COVID-19: immunopathology and its implications for therapy
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-020-0308-3
  contributor:
    fullname: Cao
– volume: 6
  start-page: 1141
  issue: 4
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0065
  article-title: Concise review: mesenchymal stromal cell-based approaches for the treatment of acute respiratory distress and sepsis syndromes
  publication-title: Stem Cells Translational Medicine
  doi: 10.1002/sctm.16-0415
  contributor:
    fullname: Johnson
– volume: 49
  start-page: 552
  issue: 4
  year: 2013
  ident: 2022061709080694700_stem3354-bib-0072
  article-title: Human mesenchymal stem cells overexpressing the IL-33 antagonist soluble IL-1 receptor-like-1 attenuate endotoxin-induced acute lung injury
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2012-0406OC
  contributor:
    fullname: Martinez-Gonzalez
– volume: 24
  start-page: 2269
  issue: 19
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0084
  article-title: Different procoagulant activity of therapeutic mesenchymal stromal cells derived from bone marrow and placental decidua
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2015.0120
  contributor:
    fullname: Moll
– volume: 35
  start-page: 256
  issue: 1
  year: 2017
  ident: 2022061709080694700_stem3354-bib-0069
  article-title: Allogeneic mesenchymal stem cells stimulate cartilage regeneration and are safe for single-stage cartilage repair in humans upon mixture with recycled autologous chondrons
  publication-title: Stem Cells
  doi: 10.1002/stem.2475
  contributor:
    fullname: de Windt
– volume: 215
  start-page: 108448
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0021
  article-title: COVID-19: immunology and treatment options
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2020.108448
  contributor:
    fullname: Felsenstein
– volume: 34
  start-page: 327
  issue: 2
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0022
  article-title: Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies
  publication-title: J Biol Regul Homeost Agents
  contributor:
    fullname: Conti
– volume: 39
  start-page: 153
  issue: 4
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0024
  article-title: Can melatonin reduce the severity of COVID-19 pandemic?
  publication-title: Int Rev Immunol
  doi: 10.1080/08830185.2020.1756284
  contributor:
    fullname: Shneider
– volume: 11
  start-page: 462
  issue: 2
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0100
  article-title: Mesenchymal stem cell infusion shows promise for combating coronavirus (COVID-19)-induced pneumonia
  publication-title: Aging Dis
  doi: 10.14336/AD.2020.0301
  contributor:
    fullname: Shetty
– volume: 852
  start-page: 68
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0123
  article-title: Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2019.01.022
  contributor:
    fullname: Li
– volume: 5
  start-page: 1048
  issue: 8
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0079
  article-title: Treatment with human Wharton's jelly-derived mesenchymal stem cells attenuates sepsis-induced kidney injury, liver injury, and endothelial dysfunction
  publication-title: Stem Cells Translational Medicine
  doi: 10.5966/sctm.2015-0138
  contributor:
    fullname: Condor
– volume: 296
  start-page: E55
  issue: 2
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0111
  article-title: Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study
  publication-title: Radiology
  doi: 10.1148/radiol.2020200843
  contributor:
    fullname: Wang
– volume: 7
  start-page: 9046
  issue: 8
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0116
  article-title: Delivery of improved oncolytic adenoviruses by mesenchymal stromal cells for elimination of tumorigenic pancreatic cancer cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.7031
  contributor:
    fullname: Kaczorowski
– volume: 18
  start-page: 128
  issue: 2
  year: 2012
  ident: 2022061709080694700_stem3354-bib-0046
  article-title: The immunomodulatory capacity of mesenchymal stem cells
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2011.10.004
  contributor:
    fullname: Gebler
– volume: 325
  start-page: 135
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0076
  article-title: Mesenchymal stromal cells and their secreted extracellular vesicles as therapeutic tools for COVID-19 pneumonia?
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.06.036
  contributor:
    fullname: Muraca
– volume: 581
  start-page: 221
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0003
  article-title: Structural basis of receptor recognition by SARS-CoV-2
  publication-title: Nature
  doi: 10.1038/s41586-020-2179-y
  contributor:
    fullname: Shang
– volume: 28
  start-page: 1378
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0023
  article-title: Does high cardiorespiratory fitness confer some protection against proinflammatory responses after infection by SARS-CoV-2?
  publication-title: Obesity
  doi: 10.1002/oby.22849
  contributor:
    fullname: Zbinden-Foncea
– year: 2020
  ident: 2022061709080694700_stem3354-bib-0002
  article-title: The science underlying COVID-19: implications for the cardiovascular system
  publication-title: Circulation
  contributor:
    fullname: Liu
– volume: 31
  start-page: 890
  issue: 10
  year: 2003
  ident: 2022061709080694700_stem3354-bib-0057
  article-title: HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
  publication-title: Exp Hematol
  doi: 10.1016/S0301-472X(03)00110-3
  contributor:
    fullname: Le Blanc
– volume: 92
  start-page: 1208
  issue: 9
  year: 2007
  ident: 2022061709080694700_stem3354-bib-0058
  article-title: No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
  publication-title: Haematologica
  doi: 10.3324/haematol.11446
  contributor:
    fullname: Sundin
– volume: 2016
  start-page: 5934782
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0062
  article-title: iPSCs: a minireview from bench to bed, including organoids and the CRISPR system
  publication-title: Stem Cells Int
  doi: 10.1155/2016/5934782
  contributor:
    fullname: Orqueda
– volume: 12
  start-page: 576
  issue: 5
  year: 2010
  ident: 2022061709080694700_stem3354-bib-0061
  article-title: Defining the risks of mesenchymal stromal cell therapy
  publication-title: Cytotherapy
  doi: 10.3109/14653249.2010.507330
  contributor:
    fullname: Prockop
– volume: 368
  start-page: 473
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0001
  article-title: Cytokine release syndrome in severe COVID-19
  publication-title: Science
  doi: 10.1126/science.abb8925
  contributor:
    fullname: Moore
– volume: 1793
  start-page: 1478
  issue: 9
  year: 2009
  ident: 2022061709080694700_stem3354-bib-0115
  article-title: Autophagy, antiviral immunity, and viral countermeasures
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbamcr.2009.02.008
  contributor:
    fullname: Shoji-Kawata
– volume: 7
  start-page: 731
  issue: 10
  year: 2018
  ident: 2022061709080694700_stem3354-bib-0083
  article-title: Clinical cellular therapeutics accelerate clot formation
  publication-title: Stem Cells Translational Medicine
  doi: 10.1002/sctm.18-0015
  contributor:
    fullname: George
– volume: 28
  start-page: 2388
  issue: 12
  year: 2014
  ident: 2022061709080694700_stem3354-bib-0051
  article-title: Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells
  publication-title: Leukemia
  doi: 10.1038/leu.2014.273
  contributor:
    fullname: Malcherek
– volume: 6
  start-page: 1153
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0028
  article-title: Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic influenza A (H7N9) infection, a hint for COVID-19 treatment
  publication-title: Engineering
  doi: 10.1016/j.eng.2020.02.006
  contributor:
    fullname: Chen
– volume: 219
  start-page: 186
  issue: 2
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0094
  article-title: Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A(H5N1) virus-associated acute lung injury
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiy478
  contributor:
    fullname: Loy
– volume: 8
  start-page: 315
  issue: 4
  year: 2006
  ident: 2022061709080694700_stem3354-bib-0040
  article-title: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
  publication-title: Cytotherapy
  doi: 10.1080/14653240600855905
  contributor:
    fullname: Dominici
– volume: 192
  start-page: 324
  issue: 3
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0120
  article-title: Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201410-1765OC
  contributor:
    fullname: Monsel
– volume: 9
  start-page: e016219
  issue: 7
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0025
  article-title: Coronavirus disease 2019 (COVID-19) and cardiovascular disease: a viewpoint on the potential influence of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers on onset and severity of severe acute respiratory syndrome coronavirus 2 infection
  publication-title: J Am Heart Assoc
  doi: 10.1161/JAHA.120.016219
  contributor:
    fullname: Guo
– volume: 5
  start-page: 227
  issue: 5
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0032
  article-title: Statins as early therapy to mitigate COVID-19 (SARS-CoV-2)-associated ARDS and cytokine storm syndrome - time is of the essence
  publication-title: J Clin Transl Res
  contributor:
    fullname: Teoh
– volume: 113
  start-page: 3621
  issue: 13
  year: 2016
  ident: 2022061709080694700_stem3354-bib-0092
  article-title: Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1601911113
  contributor:
    fullname: Chan
– volume-title: Hace2 Transgenic Mouse Model For Coronavirus (COVID-19) Research. 2020
  ident: 2022061709080694700_stem3354-bib-0110
  contributor:
    fullname: Wang
– volume: 71
  start-page: 762
  issue: 15
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0008
  article-title: Dysregulation of immune response in patients with COVID-19 in Wuhan, China
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciaa248
  contributor:
    fullname: Qin
– volume: 11
  start-page: 1868
  issue: 13
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0007
  article-title: Cytokine storm in COVID19: a neural hypothesis
  publication-title: ACS Chem Nerosci
  doi: 10.1021/acschemneuro.0c00346
  contributor:
    fullname: Ur
– volume: 40
  start-page: 14
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0056
  article-title: Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases
  publication-title: Inflamm Regen
  doi: 10.1186/s41232-020-00121-y
  contributor:
    fullname: Tsuchiya
– volume: 8
  start-page: 1025
  issue: 7
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0043
  article-title: The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity
  publication-title: J Clin Med
  doi: 10.3390/jcm8071025
  contributor:
    fullname: Zhou
– volume: 19
  start-page: 100249
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0053
  article-title: Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: an updated systematic review and meta-analysis
  publication-title: EClinicalMedicine
  doi: 10.1016/j.eclinm.2019.100249
  contributor:
    fullname: Thompson
– volume: 32
  start-page: 252
  issue: 3
  year: 2014
  ident: 2022061709080694700_stem3354-bib-0060
  article-title: Mesenchymal stem cells: immune evasive, not immune privileged
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.2816
  contributor:
    fullname: Ankrum
– volume: 56
  start-page: 6703
  issue: 10
  year: 2019
  ident: 2022061709080694700_stem3354-bib-0068
  article-title: Advances, challenges, and perspectives in translational stem cell therapy for amyotrophic lateral sclerosis
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-019-1554-x
  contributor:
    fullname: Abati
– volume: 71
  start-page: 762
  issue: 15
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0125
  article-title: Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciaa248
  contributor:
    fullname: Qin
– volume: 23
  start-page: 101303
  issue: 7
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0034
  article-title: Current status of COVID-19 therapies and drug repositioning applications
  publication-title: iScience
  doi: 10.1016/j.isci.2020.101303
  contributor:
    fullname: Altay
– volume: 29
  start-page: 747
  issue: 12
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0055
  article-title: Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2020.0080
  contributor:
    fullname: Sengupta
– volume: 76
  start-page: 16
  issue: 1
  year: 2012
  ident: 2022061709080694700_stem3354-bib-0006
  article-title: Into the eye of the cytokine storm
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.05015-11
  contributor:
    fullname: Tisoncik
– volume: 9
  start-page: 28
  issue: 1
  year: 2020
  ident: 2022061709080694700_stem3354-bib-0045
  article-title: Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome
  publication-title: Stem Cells Translational Medicine
  doi: 10.1002/sctm.19-0205
  contributor:
    fullname: Abraham
– volume: 11
  start-page: 2387
  issue: 4
  year: 2015
  ident: 2022061709080694700_stem3354-bib-0106
  article-title: Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin-converting enzyme 2 gene on bleomycin-induced lung fibrosis injury
  publication-title: Mol Med Rep
  doi: 10.3892/mmr.2014.3025
  contributor:
    fullname: Min
SSID ssj0014588
Score 2.580126
Snippet The coronavirus disease 2019 (COVID‐19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent...
The Coronavirus disease 2019 (COVID-19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent...
The coronavirus disease 2019 (COVID-19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent...
SourceID pubmedcentral
proquest
crossref
pubmed
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 707
SubjectTerms Alveoli
Cell death
Clinical trials
Concise Review
Concise Reviews
coronavirus
Coronaviruses
COVID-19
Cytokine storm
Cytokines
Edema
Epithelial cells
Epithelium
Fibrosis
Immunomodulation
Inflammation
Intravenous administration
Intravenous infusion
Lung diseases
Lungs
Mesenchymal stem cells
Microenvironments
Normalizing
Pandemics
Public health
Respiratory diseases
Respiratory distress syndrome
SARS‐CoV‐2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Stem cells
Thromboembolism
Viral diseases
Title Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID‐19 related cytokine storm
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fstem.3354
https://www.ncbi.nlm.nih.gov/pubmed/33586320
https://www.proquest.com/docview/2531434567
https://search.proquest.com/docview/2489598447
https://pubmed.ncbi.nlm.nih.gov/PMC8014246
Volume 39
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6FIiQuiHdNC1oQB6TIxY_1ixtqWiWgtoekqDfL610rURU7yuOQnvgJ_CR-C7-Emd214xAqFS5W4l157Z3Ps9-MZ2YJeZ8LBpZsyEH7ydhmIU9sDpYWWClCFLDECilVlO952L9kX66Cq07nZytqabXkR_nNX_NK_keqcA7kilmy_yDZ5qJwAn6DfOEIEobjnWR8hqlD-Xg9VUkfctpFN3x3gikf1bQSZmcuNPoHZXe2mi9Wk6WOI1fx6SoT_fji26DXhDy4ic5uARqar5fVNXJQjJ-ctknssB5KeWx72dqE4F-MJ1XLszA00b7nG80PdBWgobyz_cm8gr-bDz4LDCWpdLb2KXp5ZlXjKwBgSa0dYfW8bnsqvFZElV5FdkOBduI9wUANbeAw-lal0ckMN8IzatoobV0ByYCzrYEjvYmuWcwjnfS8s07ourMomSPf11Wst2txN52CW7spEjAcnZxh0z1yH0sx4u4NvcHX5jsW5gGr7-3mseraVo73sbnqNiPaMXN2o3XbVpSiQaPH5JGxX-hnDcYnpCPLp-SB3tF0_YzkLUhSHJsiTuifkPxEByU1gKRVQVuApAqQv77_cBNqoEhrKFIFxefk8vRkdNy3zT4edo6uajsreBBIh8eg7CMh3Ej6kRSFkwWJy9EEkK4UQMyByiY5tIog4zluCRNn3PVl4L8ge2VVyn1CJbBP5vAiQF4KXJUnieeyonB9l2dRFljkXT2X6UyXa0l1YW4vxYdOccItcljPcmre5kXqwWLEfDAnIou8bZpB1-I0ZaWsVtCHxUmQxIxBn5daKM0ocOE49D3HItGWuJoOWMd9u6WcjFU9dyzg5LHQIh-UYG-_8bRG26u7dz0gDzfv4iHZW85X8jXw6CV_o6D6GwYuyME
link.rule.ids 230,314,780,784,885,27924,27925
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mesenchymal+stem+cell+immunomodulation%3A+In+pursuit+of+controlling+COVID%E2%80%9019+related+cytokine+storm&rft.jtitle=Stem+cells+%28Dayton%2C+Ohio%29&rft.au=Song%2C+Na&rft.au=Wakimoto%2C+Hiroaki&rft.au=Rossignoli%2C+Filippo&rft.au=Bhere%2C+Deepak&rft.date=2021-06-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=1066-5099&rft.eissn=1549-4918&rft.volume=39&rft.issue=6&rft.spage=707&rft.epage=722&rft_id=info:doi/10.1002%2Fstem.3354&rft.externalDBID=10.1002%252Fstem.3354&rft.externalDocID=STEM3354
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1066-5099&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1066-5099&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1066-5099&client=summon