Pharmacokinetics and safety of the sesame lignans, sesamin and episesamin, in healthy subjects

• Published in: Biopharmaceutics & drug disposition Vol. 34; no. 8; pp. 462 - 473
• Main Authors: Tomimori, Namino, Tanaka, Yasuhiro, Kitagawa, Yoshinori, Fujii, Wataru, Sakakibara, Yutaka, Shibata, Hiroshi
• Format: Journal Article
• Language: English
• Published: Chichester Blackwell Publishing Ltd 01.11.2013; Wiley; Wiley Subscription Services, Inc
• Subjects: Adult; Biological and medical sciences; CYP2C9; Dioxoles - adverse effects; Dioxoles - blood; Dioxoles - pharmacokinetics; Female; Humans; Lignans - adverse effects; Lignans - blood; Lignans - pharmacokinetics; Male; Medical sciences; Middle Aged; pharmacokinetics; Pharmacology. Drug treatments; safety; sesame lignan; sesamin; Sesamum; Young Adult; Human; Healthy subject; Enzyme; Isozyme; Toxicity; Cytochrome P450; Phytoestrogen; CYP2C9; safety; Lignan; sesamin; Pharmacokinetics; CYP2C9 gene; sesame lignan; Sesame; pharmacokinetics

ABSTRACT A single‐blind, placebo‐controlled, parallel‐group and multiple oral dose study was conducted in 48 healthy subjects to investigate the pharmacokinetics and safety of multiple oral doses of sesame lignans (sesamin and episesamin). Subjects were randomly divided into two groups. Each subject...