miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer

• Published in: Cancer science Vol. 102; no. 12; pp. 2264 - 2271
• Main Authors: Tsuchida, Akihiko, Ohno, Shinichiro, Wu, Weihong, Borjigin, Nariso, Fujita, Koji, Aoki, Tastuya, Ueda, Shinobu, Takanashi, Masakatsu, Kuroda, Masahiko
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2011; Blackwell
• Subjects: Adenoma; Adenoma - genetics; Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins - metabolism; Bcl-2-Like Protein 11; BIM protein; Biological and medical sciences; biomarkers; Carcinoma - genetics; Cell Line, Tumor; Colon cancer; Colonic Neoplasms - genetics; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colorectal cancer; Colorectal carcinoma; copy number; Data processing; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Dosage; Gene Expression Regulation, Neoplastic; Humans; Male; Medical sciences; Membrane Proteins - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Multigene Family; Oligoribonucleotides - pharmacology; Prognosis; Proto-Oncogene Proteins - metabolism; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transcription; Tumors; Colonic disease; Colon cancer; Cancerology; Digestive diseases; Intestinal disease; Malignant tumor; Carcinogenesis; Cancer

MicroRNAs (miRNAs) belong to a class of endogenously expressed non‐coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR‐17–92 clus...