miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer

MicroRNAs (miRNAs) belong to a class of endogenously expressed non‐coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR‐17–92 clus...

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Published in	Cancer science Vol. 102; no. 12; pp. 2264 - 2271
Main Authors	Tsuchida, Akihiko, Ohno, Shinichiro, Wu, Weihong, Borjigin, Nariso, Fujita, Koji, Aoki, Tastuya, Ueda, Shinobu, Takanashi, Masakatsu, Kuroda, Masahiko
Format	Journal Article
Language	English
Published	Oxford, UK Blackwell Publishing Ltd 01.12.2011 Blackwell
Subjects	Adenoma Adenoma - genetics Aged Aged, 80 and over Apoptosis Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 BIM protein Biological and medical sciences biomarkers Carcinoma - genetics Cell Line, Tumor Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma copy number Data processing Female Gastroenterology. Liver. Pancreas. Abdomen Gene Dosage Gene Expression Regulation, Neoplastic Humans Male Medical sciences Membrane Proteins - metabolism MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Multigene Family Oligoribonucleotides - pharmacology Prognosis Proto-Oncogene Proteins - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription Tumors Colonic disease Colon cancer Cancerology Digestive diseases Intestinal disease Malignant tumor Carcinogenesis Cancer
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Abstract	MicroRNAs (miRNAs) belong to a class of endogenously expressed non‐coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR‐17–92 cluster has emerged as an important locus, being highly overexpressed in several cancers in association with cancer development and progression. The miR‐17–92 miRNA cluster generates a single polycistronic primary transcript that yields six mature miRNAs: miR‐17, miR‐18a, miR‐19a, miR‐20a, miR‐19b, and miR‐92a. In colon cancer development, the pathophysiologic roles of these transcripts and their targets are largely unknown. In the present study, we performed copy number analyses of the six miRNAs transcribed from the miR‐17–92 cluster in colon tumor tissues. We determined that miR‐92a was transcribed at higher levels than the other five miRNAs in both adenomas and carcinoma. In addition, miR‐92a directly targeted the anti‐apoptotic molecule BCL‐2‐interacting mediator of cell death (BIM) in colon cancer tissues. An anti‐miR‐92a antagomir induced apoptosis of colon cancer‐derived cell lines. These data indicate that miR‐92a plays a pivotal role in the development of colorectal carcinoma. (Cancer Sci 2011; 102: 2264–2271)
AbstractList	MicroRNAs (miRNAs) belong to a class of endogenously expressed non-coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR-17-92 cluster has emerged as an important locus, being highly overexpressed in several cancers in association with cancer development and progression. The miR-17-92 miRNA cluster generates a single polycistronic primary transcript that yields six mature miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a. In colon cancer development, the pathophysiologic roles of these transcripts and their targets are largely unknown. In the present study, we performed copy number analyses of the six miRNAs transcribed from the miR-17-92 cluster in colon tumor tissues. We determined that miR-92a was transcribed at higher levels than the other five miRNAs in both adenomas and carcinoma. In addition, miR-92a directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues. An anti-miR-92a antagomir induced apoptosis of colon cancer-derived cell lines. These data indicate that miR-92a plays a pivotal role in the development of colorectal carcinoma.MicroRNAs (miRNAs) belong to a class of endogenously expressed non-coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR-17-92 cluster has emerged as an important locus, being highly overexpressed in several cancers in association with cancer development and progression. The miR-17-92 miRNA cluster generates a single polycistronic primary transcript that yields six mature miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a. In colon cancer development, the pathophysiologic roles of these transcripts and their targets are largely unknown. In the present study, we performed copy number analyses of the six miRNAs transcribed from the miR-17-92 cluster in colon tumor tissues. We determined that miR-92a was transcribed at higher levels than the other five miRNAs in both adenomas and carcinoma. In addition, miR-92a directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues. An anti-miR-92a antagomir induced apoptosis of colon cancer-derived cell lines. These data indicate that miR-92a plays a pivotal role in the development of colorectal carcinoma. MicroRNAs (miRNAs) belong to a class of endogenously expressed non-coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR-17-92 cluster has emerged as an important locus, being highly overexpressed in several cancers in association with cancer development and progression. The miR-17-92 miRNA cluster generates a single polycistronic primary transcript that yields six mature miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a. In colon cancer development, the pathophysiologic roles of these transcripts and their targets are largely unknown. In the present study, we performed copy number analyses of the six miRNAs transcribed from the miR-17-92 cluster in colon tumor tissues. We determined that miR-92a was transcribed at higher levels than the other five miRNAs in both adenomas and carcinoma. In addition, miR-92a directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues. An anti-miR-92a antagomir induced apoptosis of colon cancer-derived cell lines. These data indicate that miR-92a plays a pivotal role in the development of colorectal carcinoma. (Cancer Sci 2011; 102: 2264-2271) MicroRNAs (miRNAs) belong to a class of endogenously expressed non‐coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR‐17–92 cluster has emerged as an important locus, being highly overexpressed in several cancers in association with cancer development and progression. The miR‐17–92 miRNA cluster generates a single polycistronic primary transcript that yields six mature miRNAs: miR‐17, miR‐18a, miR‐19a, miR‐20a, miR‐19b, and miR‐92a. In colon cancer development, the pathophysiologic roles of these transcripts and their targets are largely unknown. In the present study, we performed copy number analyses of the six miRNAs transcribed from the miR‐17–92 cluster in colon tumor tissues. We determined that miR‐92a was transcribed at higher levels than the other five miRNAs in both adenomas and carcinoma. In addition, miR‐92a directly targeted the anti‐apoptotic molecule BCL‐2‐interacting mediator of cell death (BIM) in colon cancer tissues. An anti‐miR‐92a antagomir induced apoptosis of colon cancer‐derived cell lines. These data indicate that miR‐92a plays a pivotal role in the development of colorectal carcinoma. ( Cancer Sci 2011; 102: 2264–2271) MicroRNAs (miRNAs) belong to a class of endogenously expressed non-coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR-17-92 cluster has emerged as an important locus, being highly overexpressed in several cancers in association with cancer development and progression. The miR-17-92 miRNA cluster generates a single polycistronic primary transcript that yields six mature miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a. In colon cancer development, the pathophysiologic roles of these transcripts and their targets are largely unknown. In the present study, we performed copy number analyses of the six miRNAs transcribed from the miR-17-92 cluster in colon tumor tissues. We determined that miR-92a was transcribed at higher levels than the other five miRNAs in both adenomas and carcinoma. In addition, miR-92a directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues. An anti-miR-92a antagomir induced apoptosis of colon cancer-derived cell lines. These data indicate that miR-92a plays a pivotal role in the development of colorectal carcinoma.
Author	TAKANASHI Masakatsu AOKI Tastuya UEDA Shinobu KURODA Masahiko TSUCHIDA Akihiko BORJIGIN Nariso OHNO Shinichiro WU Weihong FUJITA Koji
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Snippet	MicroRNAs (miRNAs) belong to a class of endogenously expressed non‐coding small RNAs that function primarily as gene regulators. Growing evidence suggests that... MicroRNAs (miRNAs) belong to a class of endogenously expressed non-coding small RNAs that function primarily as gene regulators. Growing evidence suggests that...
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SubjectTerms	Adenoma Adenoma - genetics Aged Aged, 80 and over Apoptosis Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 BIM protein Biological and medical sciences biomarkers Carcinoma - genetics Cell Line, Tumor Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma copy number Data processing Female Gastroenterology. Liver. Pancreas. Abdomen Gene Dosage Gene Expression Regulation, Neoplastic Humans Male Medical sciences Membrane Proteins - metabolism MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Multigene Family Oligoribonucleotides - pharmacology Prognosis Proto-Oncogene Proteins - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription Tumors
Title	miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer
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