Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease

• Published in: Journal of comparative neurology (1911) Vol. 515; no. 3; pp. 269 - 294
• Main Authors: Leonard, Brian W., Mastroeni, Diego, Grover, Andrew, Liu, Qiang, Yang, Kechun, Gao, Ming, Wu, Jie, Pootrakul, David, van den Berge, Simone A., Hol, Elly M., Rogers, Joseph
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 20.07.2009
• Subjects: Aged; Aged, 80 and over; Alzheimer's disease; Animals; Autopsy; Biomarkers - metabolism; Cell Differentiation - physiology; Cells, Cultured; Cerebral Ventricles - cytology; Cerebral Ventricles - metabolism; Glial Fibrillary Acidic Protein - metabolism; Humans; Mice; Middle Aged; neural precursors; neural stem cells; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; neuronal differentiation; Neurons - cytology; Neurons - physiology; neurospheres; Patch-Clamp Techniques; Stem Cells - cytology; Stem Cells - physiology

In mice and in young adult humans, the subventricular zone (SVZ) contains multipotent, dividing astrocytes, some of which, when cultured, produce neurospheres that differentiate into neurons and glia. It is unknown whether the SVZ of very old humans has this capacity. Here, we report that neural ste...