Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors - Tong, Ricky T.; Boucher, Yves; Kozin, Sergey V.; Winkler, Frank; Hicklin, Daniel J.; Jain, Rakesh K. (Cancer research (Chicago, Ill.), 2004)
Keywords: Animals; Antibodies - immunology; Antibodies - pharmacology; Antineoplastic agents; Biological and medical sciences; Capillary Permeability - drug effects; Cell Line, Tumor; Humans; Hydrostatic Pressure; Medical sciences; Mice; Mice, SCID; Neoplasms - blood supply; Neoplasms - drug therapy; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - therapy; Pharmacology. Drug treatments; Serum Albumin, Bovine - pharmacokinetics; Tumors; Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2 - immunology; Drug; Gradient; Penetration; Blood vessel; Circulatory system; Malignant tumor; Vascular endothelial growth factor receptor 2; Pressure