Antioxidative NAC-Loaded Silk Nanoparticles with Opening Mucosal Tight Junctions for Nasal Drug Delivery: An In Vitro and In Vivo Study

• Published in: Pharmaceutics Vol. 14; no. 6; p. 1288
• Main Authors: Chung, Tze-Wen, Wu, Ting-Ya, Siah, Zheng-Yu, Liu, Der-Zen
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 17.06.2022; MDPI
• Subjects: anti-oxidative; Fourier transforms; Hydrogels; IVIS study; mucosal cells; Nanoparticles; nasal NAC delivery; Particle size; Polymers; SF/NAC NP; tight junction; Traumatic brain injury; United States > US; Switzerland; Japan

Using nasal routes to deliver drugs to the brain using multifunctional nanoparticles (NPs) to bypass the blood–brain barrier (BBB) might enhance the delivery efficacy. Anti-oxidative N-Acetyl-L-cysteine (NAC)-loaded silk fibroin (SF/NAC) NPs are produced, characterized and studied as a potential del...