Detection of caseinophosphopeptides in the distal ileostomy fluid of human subjects

• Published in: British journal of nutrition Vol. 89; no. 3; pp. 351 - 358
• Main Authors: Meisel, H., Fairweather-Tait, S., FitzGerald, R. J., Hartmann, R., Lane, C. N., McDonagh, D., Teucher, B., Wal, J. M.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.03.2003
• Subjects: Adult; Amino acids; Animals; Bioactive peptides; Biological and medical sciences; Caseinophosphopeptides; Caseins; Caseins - immunology; Caseins - pharmacokinetics; chemistry; Chromatography, High Pressure Liquid; Chromatography, High Pressure Liquid - methods; Dietary minerals; digesta; Digestion; Enzymes; Female; Food; Functional foods & nutraceuticals; Fundamental and applied biological sciences. Psychology; Gastrointestinal Contents; Gastrointestinal Contents - chemistry; Human ileostomy samples; human nutrition; human physiology; Human subjects; Humans; Ileostomy; immunology; Ingestion; Intestine. Mesentery; Liquid chromatography; Male; men; metabolism; methods; Middle Aged; Milk; Milk - metabolism; Nutrition; Ostomy; patients; Peptide Fragments; Peptide Fragments - immunology; Peptide Fragments - pharmacokinetics; Peptides; pharmacokinetics; Phosphopeptides; Phosphopeptides - immunology; Phosphopeptides - pharmacokinetics; Proteins; Research parks; Small intestine; Vertebrates: digestive system; Volunteers; women; United Kingdom > UK; Ireland; Human ileostomy samples; Bioactive peptides; Caseinophosphopeptides; Milk; Human; Ileostomy; Biological fluid; Digestive system; Phosphopeptide; Supplemented diet; Caseinophosphopeptides: Milk: Human ileostomy samples: Bioactive peptides; Small intestine; Ileum; Feeding; Casein; Cow milk; Detection

Caseinophosphopeptides (CPP) were detected for the first time in ileostomy fluid, collected at 2 h intervals for 10 h post milk and CPP ingestion, from human volunteers with an ileostomy. The level of CPP present in ileostomy fluid obtained from milk-fed volunteers was markedly higher than that from...