Reactive Oxygen Species: A Breath of Life or Death?

• Published in: Clinical cancer research Vol. 13; no. 3; pp. 789 - 794
• Main Authors: Fruehauf, John P., Meyskens, Frank L.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.02.2007
• Subjects: Antineoplastic agents; Apoptosis; Biological and medical sciences; Cell Death and Senescence; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Glutathione metabolism; Humans; Hydrogen Peroxide - pharmacology; Hypoxia - metabolism; hypoxia inducible factor; Medical sciences; Mitochondria - metabolism; mitochondrial permeability pore; Models, Biological; Neoplasms - metabolism; Novel antitumor agents; Permeability; Pharmacology. Drug treatments; Reactive oxygen and carcinogenesis; Reactive Oxygen Species; Signal Transduction; tyrosine kinase signaling; Oxidative stress; Death; Reactive oxygen species; Mortality

New insights into cancer cell–specific biological pathways are urgently needed to promote development of rationally targeted therapeutics. Reactive oxygen species (ROS) and their role in cancer cell response to growth factor signaling and hypoxia are emerging as verdant areas of exploration on the r...