Lateral septum microglial changes and behavioral abnormalities of mice exposed to valproic acid during the prenatal period

• Published in: Journal of chemical neuroanatomy Vol. 111; p. 101875
• Main Authors: de Leão, Ellen Rose Leandro Ponce, de Souza, Dilza Nazaré Colares, de Moura, Larissa Victória Barra, da Silveira Júnior, Antonio Morais, dos Santos, Alinne Lorrany Gomes, Diniz, Daniel Guerreiro, Diniz, Cristovam Wanderley Picanço, Sosthenes, Marcia Consentino Kronka
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021
• Subjects: ASD model; Elevated plus maze; Microglia; Open field; Optical fractionator; Valproic acid; ASD model; Valproic acid; Open field; Elevated plus maze; Optical fractionator; Microglia

•Valproic acid-exposed mice in utero altered behavior in exploring novel environments and assessing risk at adulthood.•Increased microglia in the lateral septum might be part of cellular changes associated with behavioral dysfunction in ASD. Most animal model studies of autism spectrum disorder (ASD...