Success and Failures of Combined Modalities in Glioblastoma Multiforme: Old Problems and New Directions

Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approac...

Full description

Saved in:
Bibliographic Details
Published inSeminars in radiation oncology Vol. 26; no. 4; pp. 281 - 298
Main Authors Corso, Christopher D., Bindra, Ranjit S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2016
Subjects
Brain Neoplasms - therapy
Combined Modality Therapy - methods
Combined Modality Therapy - trends
Glioblastoma - therapy
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
Medical Oncology
Radiation-Sensitizing Agents - therapeutic use
Radiology
Treatment Outcome
Online AccessGet full text

Cover

Abstract Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approach. In this review, the historical basis for the current standard treatment is discussed as well as other recent combined modality successes and failures. An overview of emerging combined modality therapies for GBM is presented including immunotherapy, and rationally designed radiosensitizers. Unanswered questions facing the oncology community regarding the treatment of GBM are also discussed.
AbstractList Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approach. In this review, the historical basis for the current standard treatment is discussed as well as other recent combined modality successes and failures. An overview of emerging combined modality therapies for GBM is presented including immunotherapy, and rationally designed radiosensitizers. Unanswered questions facing the oncology community regarding the treatment of GBM are also discussed.
Author Bindra, Ranjit S.
Corso, Christopher D.
Author_xml – sequence: 1
  givenname: Christopher D.
  surname: Corso
  fullname: Corso, Christopher D.
– sequence: 2
  givenname: Ranjit S.
  surname: Bindra
  fullname: Bindra, Ranjit S.
  email: Ranjit.bindra@yale.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27619250$$D View this record in MEDLINE/PubMed
BookMark eNqNUl1vFSEUJKbGfuhfUB59udcDy35goqa52mrSWpPqM2HhrOHKQgu7mv57WW_rQxNjk5NADjMDzJxDshdiQEJeMFgzYM2r7TrjmLSNwax5aayhFFSPyAGrK76SomF7ZQ91tRJcNvvkMOctAGctl0_IPm8bJnkNB-T75WwM5kx1sPREOz8nzDQOdBPH3gW09Dxa7d3kStsFeupd7L3OUxw1PZ_95IaYRnxNL7ylX1I5w3En9hl_0fcuoZlcDPkpeTxon_HZ7XpEvp18-Lr5uDq7OP20OT5bGdHxaWU70I1o2k7IgffQdCg1tLwZpBg41ihkLfrBCF7bXiDTvemkLiDZYzXwVldH5OVO9yrF6xnzpEaXDXqvA8Y5K9YxKSoQNRTo81vo3I9o1VVyo0436s6cAnizA5gUc044KOMmvXxnSsUpxUAtYait-huGWsJQUAqqwm_v8e-u-D_zeMfEYtVPh0ll4zAYtH8MVTa6B2i8vadhvAvOaP8DbzBv45xCSUIxlbkCdbkMyzIrrKkAWMeLwLt_CzzoCb8BNl3UHw
CitedBy_id crossref_primary_10_1016_j_brainresbull_2024_111184
crossref_primary_10_1016_j_canlet_2018_06_004
crossref_primary_10_1038_s41419_018_1293_3
crossref_primary_10_1186_s13014_023_02241_4
crossref_primary_10_3390_cells13110942
crossref_primary_10_1016_j_brainres_2021_147515
crossref_primary_10_1093_nop_npz057
crossref_primary_10_1007_s00018_017_2483_3
crossref_primary_10_1016_j_cellsig_2020_109638
crossref_primary_10_3389_fonc_2021_703764
crossref_primary_10_1016_j_jconrel_2023_08_048
crossref_primary_10_1016_j_jconrel_2017_06_028
crossref_primary_10_1515_jib_2021_0031
crossref_primary_10_3390_cancers9050051
crossref_primary_10_1016_j_neuint_2020_104891
crossref_primary_10_1186_s13014_021_01918_y
crossref_primary_10_1021_acs_molpharmaceut_9b00018
crossref_primary_10_3390_molecules23061401
crossref_primary_10_1002_nbm_4855
crossref_primary_10_1007_s11060_016_2347_y
crossref_primary_10_1016_j_jconrel_2017_03_017
crossref_primary_10_1016_j_semradonc_2016_07_002
crossref_primary_10_1158_1535_7163_MCT_16_0788
Cites_doi 10.1016/j.ijrobp.2013.12.011
10.1007/s11864-015-0371-3
10.1016/j.molonc.2014.06.008
10.1016/S0140-6736(02)08091-1
10.1158/1078-0432.CCR-15-1381
10.1038/nature03445
10.1038/nature06168
10.1016/0360-3016(86)90267-1
10.1016/j.molcel.2010.09.019
10.1200/JCO.2015.62.6606
10.1016/j.tcb.2015.07.009
10.1097/COC.0b013e3182937921
10.1016/0092-8674(93)90493-A
10.1158/1078-0432.CCR-03-0384
10.1517/14712598.2011.579097
10.1200/JCO.2005.05.098
10.1158/1535-7163.MCT-11-0278
10.1084/jem.20070255
10.3346/jkms.2004.19.6.879
10.1186/1748-717X-7-41
10.1038/bjc.1992.57
10.1103/RevModPhys.82.383
10.1038/nature06020
10.1177/039463200401700108
10.3109/02841867809128178
10.1016/0360-3016(95)02025-X
10.1038/nature03443
10.1038/nrc3399
10.1126/scitranslmed.3003649
10.1093/jnci/djh005
10.1002/1097-0142(19830915)52:6<997::AID-CNCR2820520612>3.0.CO;2-2
10.1097/00001813-199701000-00013
10.1371/journal.pone.0101764
10.1227/01.NEU.0000159649.71890.30
10.1056/NEJMoa1308345
10.1007/BF01057964
10.1038/nrc2812
10.1109/TBME.2009.2034533
10.1016/j.addr.2015.11.007
10.1371/journal.pone.0016195
10.1016/S1470-2045(11)70196-6
10.1074/jbc.R700039200
10.1177/153303460600500307
10.1016/S0360-3016(99)00539-8
10.1215/15228517-2006-008
10.1093/neuonc/nov164
10.1016/j.ctrv.2010.03.003
10.1158/1078-0432.728.11.2
10.1158/0008-5472.CAN-09-3074
10.1158/0008-5472.CAN-11-1245
10.1158/1078-0432.CCR-04-2588
10.1007/s11060-011-0610-9
10.1038/nrc3185
10.1038/nrc2748
10.1038/nature13387
10.1046/j.1471-4159.1998.70051781.x
10.1200/JCO.2015.62.4270
10.1158/1078-0432.CCR-05-0060
10.1093/neuonc/noq072
10.1016/0360-3016(85)90034-3
10.1158/1535-7163.MCT-14-0113
10.1016/j.ijrobp.2009.02.057
10.1016/j.molcel.2006.04.023
10.1200/JCO.2013.49.6968
10.1146/annurev-pathol-011110-130324
10.1016/j.ijrobp.2004.04.011
10.1007/s00018-010-0491-7
10.1007/BF02427832
10.1158/1078-0432.CCR-04-1737
10.1084/jem.20052494
10.1016/0360-3016(89)90941-3
10.3171/jns.1978.49.3.0333
10.1016/0167-8140(91)90203-S
10.1038/sj.bjc.6690802
10.1016/j.ijrobp.2005.05.067
10.1200/JCO.1999.17.8.2604
10.1593/tlo.12280
10.1016/S1470-2045(06)70867-1
10.1016/j.ijrobp.2011.09.049
10.1016/j.ijrobp.2008.07.031
10.1200/JCO.2000.18.6.1254
10.1093/neuonc/nov159
10.1200/JCO.2010.30.0921
10.1016/j.chembiol.2014.11.013
10.3389/fonc.2015.00055
10.1016/S0360-3016(97)00039-4
10.1200/JCO.2008.18.8417
10.1200/JCO.20.6.1635
10.1016/S1470-2045(06)70665-9
10.1371/journal.pone.0132266
10.1016/S1470-2045(12)70265-6
10.1007/s002800050691
10.1056/NEJMoa1001294
10.1016/j.ccr.2009.12.020
10.1097/00130404-200201000-00009
10.1056/NEJMoa032691
10.1158/1535-7163.MCT-13-0803
10.3171/jns.1994.80.6.1074
10.1056/NEJMoa1112824
10.1021/bi00197a003
10.1007/s12029-014-9673-0
10.1016/S0959-8049(96)00258-4
10.1158/0008-5472.CAN-14-3790
10.1016/0360-3016(90)90096-3
10.1001/jama.1928.02690380007003
10.1073/pnas.1304504110
10.1200/JCO.2007.12.2440
10.1093/neuonc/nop054
10.1007/s11060-015-1762-9
10.1200/JCO.20.5.1375
10.3171/jns.1991.75.4.0559
10.1200/JCO.2001.19.3.843
10.3390/biom5043204
10.1200/JCO.2001.19.2.509
10.1155/2013/658126
10.3171/jns.2001.95.2.0190
10.1158/1078-0432.CCR-14-3220
10.1016/S0025-6196(12)65470-6
10.1002/glia.20201
10.1158/0008-5472.CAN-05-3773
10.1016/S0959-8049(05)80198-4
10.1002/pbc.24433
10.3171/2011.2.JNS10998
10.1200/JCO.2008.16.3055
10.1158/0008-5472.CAN-08-4853
10.1016/j.radonc.2010.01.015
10.1158/1078-0432.CCR-06-0596
10.1093/annonc/mdt388
10.1227/00006123-198803000-00003
10.1016/0360-3016(79)90044-0
10.1016/j.nec.2009.08.005
10.1016/j.jocn.2013.09.005
10.1158/1078-0432.CCR-13-3446
10.1073/pnas.90.12.5613
10.1371/journal.pone.0097655
10.1021/jm00368a016
10.1016/j.ijrobp.2007.03.002
10.1667/RR0813.1
10.1126/science.1236188
10.3892/ijo.2012.1539
10.1016/0360-3016(91)90243-W
10.1158/1078-0432.CCR-06-0593
10.1016/j.ijrobp.2006.10.010
10.1056/NEJMoa1003466
10.1016/j.ijrobp.2012.12.025
10.1200/JCO.2010.28.6963
10.1158/1078-0432.CCR-09-0265
10.1124/jpet.113.210146
10.1038/nature14320
10.1093/neuonc/noq142
10.1038/bjc.2014.209
10.1111/j.1750-3639.2008.00137.x
10.1158/2326-6066.CIR-13-0115
10.3171/jns.1989.71.1.0001
10.1016/j.ijrobp.2009.04.026
10.1016/j.ijrobp.2007.04.017
10.1016/j.ijrobp.2009.12.061
10.1016/0360-3016(79)90553-4
10.1007/s00262-012-1319-0
10.1054/bjoc.2000.1316
10.1038/nrneurol.2009.197
10.1016/j.currproblcancer.2015.10.003
10.1016/S0165-5728(99)00203-9
10.1093/neuonc/nou212
10.1016/j.ijrobp.2003.08.024
10.1186/1748-717X-9-130
10.1016/j.ijrobp.2007.07.2366
10.1007/s13346-010-0001-3
10.1016/S0360-3016(99)00122-4
10.1158/1541-7786.MCR-15-0191-T
10.1200/JCO.2004.08.110
10.1200/JCO.2008.19.8721
10.1056/NEJMoa1200694
10.1212/WNL.30.9.907
10.1016/j.ijrobp.2005.08.013
10.1056/NEJMoa1308573
10.1016/S1470-2045(14)70379-1
10.1200/JCO.2004.06.082
10.1093/neuonc/noq157
10.1515/REVNEURO.2010.21.1.29
10.1016/S1074-7613(94)80021-9
10.1158/1078-0432.CCR-06-2309
10.1016/j.jneuroim.2010.05.020
10.2217/imt.11.39
10.1158/0008-5472.CAN-04-1525
10.1200/JCO.1999.17.9.2762
10.1093/neuonc/nou348
10.1158/1535-7163.MCT-09-0201
10.1056/NEJM198012043032303
10.1016/S0360-3016(96)00542-1
10.1056/NEJMoa043330
10.1016/S0360-3016(97)00566-X
10.1093/neuonc/not085
10.1016/j.pharmthera.2011.11.010
10.1016/j.ijrobp.2014.12.050
10.1016/j.clgc.2012.01.004
10.1002/(SICI)1520-6823(1998)6:2<63::AID-ROI1>3.0.CO;2-F
10.1073/pnas.0708541104
10.1084/jem.192.7.1027
10.1016/j.ijrobp.2009.12.010
10.1007/s11060-009-9801-z
10.3171/jns.1999.91.2.0251
10.1056/NEJMoa1215134
ContentType Journal Article
Copyright 2016 Elsevier Inc.
Elsevier Inc.
Copyright © 2016 Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2016 Elsevier Inc.
– notice: Elsevier Inc.
– notice: Copyright © 2016 Elsevier Inc. All rights reserved.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1016/j.semradonc.2016.06.003
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1532-9461
EndPage 298
ExternalDocumentID 27619250
10_1016_j_semradonc_2016_06_003
S1053429616300182
1_s2_0_S1053429616300182
Genre Journal Article
Review
GroupedDBID ---
--K
--M
.1-
.FO
.~1
0R~
123
1B1
1P~
1RT
1~.
1~5
4.4
457
4CK
4G.
53G
5VS
7-5
8P~
9JM
AAEDT
AAEDW
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQQT
AAQXK
AATTM
AAWTL
AAXKI
AAXUO
AAYWO
ABBQC
ABFNM
ABFRF
ABJNI
ABLJU
ABMAC
ABMZM
ABWVN
ABXDB
ACDAQ
ACGFO
ACGFS
ACIEU
ACJTP
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADMUD
ADNMO
ADVLN
AEBSH
AEFWE
AEIPS
AEKER
AENEX
AEUPX
AEVXI
AFJKZ
AFPUW
AFRHN
AFTJW
AFXBA
AFXIZ
AGCQF
AGHFR
AGQPQ
AGUBO
AGYEJ
AHHHB
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJRQY
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
C5W
DU5
EBS
EFJIC
EFKBS
EJD
EO8
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HED
HMK
HMO
HVGLF
HZ~
IH2
IHE
J1W
K-O
KOM
M27
M41
MO0
NQ-
O-L
O9-
OAUVE
OC~
OO-
P-8
P-9
P2P
PC.
Q38
R2-
ROL
RPZ
SAE
SDF
SEL
SES
SEW
SNG
SPCBC
SSH
SSZ
T5K
UDS
UNMZH
WUQ
Z5R
~G-
AACTN
AFCTW
AFKWA
AJOXV
AMFUW
RIG
AAIAV
ZA5
AAYXX
AGRNS
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ID FETCH-LOGICAL-c482t-d80a6467849f2b068e9a0726f94f2e5e4954bfc425db4e1abc89a8e99be3f27a3
IEDL.DBID .~1
ISSN 1053-4296
IngestDate Fri Jul 11 12:27:48 EDT 2025
Wed Feb 19 02:43:16 EST 2025
Thu Apr 24 23:05:07 EDT 2025
Tue Jul 01 02:43:25 EDT 2025
Tue Jul 09 07:17:51 EDT 2024
Tue Feb 25 19:55:56 EST 2025
Tue Aug 26 16:31:50 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License Copyright © 2016 Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c482t-d80a6467849f2b068e9a0726f94f2e5e4954bfc425db4e1abc89a8e99be3f27a3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMID 27619250
PQID 1819430450
PQPubID 23479
PageCount 18
ParticipantIDs proquest_miscellaneous_1819430450
pubmed_primary_27619250
crossref_citationtrail_10_1016_j_semradonc_2016_06_003
crossref_primary_10_1016_j_semradonc_2016_06_003
elsevier_sciencedirect_doi_10_1016_j_semradonc_2016_06_003
elsevier_clinicalkeyesjournals_1_s2_0_S1053429616300182
elsevier_clinicalkey_doi_10_1016_j_semradonc_2016_06_003
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-10-01
PublicationDateYYYYMMDD 2016-10-01
PublicationDate_xml – month: 10
  year: 2016
  text: 2016-10-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Seminars in radiation oncology
PublicationTitleAlternate Semin Radiat Oncol
PublicationYear 2016
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Denny, Wheelhouse, Stevens (bib71) 1994; 33
Sawamura, Diserens, de Tribolet (bib98) 1990; 9
Facoetti, Nano, Zelini (bib95) 2005; 11
Kreth, Thon, Simon (bib11) 2013; 24
Stupp, Dietrich, Ostermann Kraljevic (bib70) 2002; 20
Nonoguchi, Miyatake, Fukumoto (bib138) 2011; 105
Hottinger, Aissa, Espeli (bib146) 2014; 110
Golden, Demaria, Schiff (bib197) 2013; 1
Andersen (bib16) 1978; 17
Lacroix, Abi-Said, Fourney (bib8) 2001; 95
Gupta, Jaskowiak, Beckett (bib145) 2002; 8
Corneo, Wendland, Deriano (bib158) 2007; 449
Liang, Thornton, Sandler (bib21) 1991; 75
Murai, Huang, Renaud (bib174) 2014; 13
Del Rowe, Scott, Werner-Wasik (bib118) 2000; 18
Park, Bagatell, London (bib6) 2013; 60
bib110
Patel, Shapiro, Laske (bib218) 2005; 56
Boothe, Young, Yamada (bib140) 2013; 15
Gordon, Margolin, Talpaz (bib128) 2001; 19
Oberoi, Parrish, Sio (bib43) 2016; 18
Cloughesy, Cavenee, Mischel (bib46) 2014; 9
McGee, Hamner, Williams (bib144) 2010; 76
Gonzalez, Kumar, Conrad (bib139) 2007; 67
Ahmed, Carruthers, Gilmour (bib166) 2015; 75
Lv, Teugels, Sadones (bib228) 2012; 41
Newlands, Blackledge, Slack (bib56) 1985; 69
Scaringi, Enrici, Minniti (bib143) 2013; 6
Kantoff, Higano, Shore (bib186) 2010; 363
Newlands, Blackledge, Slack (bib59) 1992; 65
Schnell, Krebs, Wagner (bib149) 2008; 18
Zeman, Brown, Lemmon (bib115) 1986; 12
Curtin (bib168) 2012; 12
Kelly, Daumas-Duport, Scheithauer (bib14) 1987; 62
Dewan, Galloway, Kawashima (bib212) 2009; 15
Parker, Khong, Parkinson (bib224) 2015; 5
Gilbert, Wang, Aldape (bib84) 2013; 31
Prados, Seiferheld, Sandler (bib121) 2004; 58
van Nifterik, van den Berg, Stalpers (bib82) 2007; 69
Hochberg, Pruitt (bib19) 1980; 30
Ford, Seiferheld, Alger (bib122) 2007; 69
Schaue, Ratikan, Iwamoto (bib210) 2012; 83
Stupp, Mason, van den Bent (bib40) 2005; 352
Stewart (bib53) 2002; 359
Demaria, Kawashima, Yang (bib193) 2005; 11
Bower, Newlands, Bleehen (bib65) 1997; 40
Kunwar, Chang, Westphal (bib220) 2010; 12
Shapiro, Green, Burger (bib51) 1989; 71
Rouleau, Patel, Hendzel (bib170) 2010; 10
Green, Byar, Walker (bib50) 1983; 67
Brown, Lemmon (bib117) 1991; 20
Rieken, Habermehl, Haberer (bib32) 2012; 7
Hopkins, Shi, Rodriguez (bib175) 2015; 13
Aziz, Nowsheen, Pantelias (bib167) 2012; 133
Gupta, Mladek, Carlson (bib176) 2014; 20
Chakravarti, Erkkinen, Nestler (bib80) 2006; 12
Yung, Prados, Yaya-Tur (bib67) 1999; 17
Newcomb, Demaria, Lukyanov (bib201) 2006; 12
Zhou, Patel, Sirianni (bib223) 2013; 110
Yoshioka, Yoshioka, Hsieh (bib74) 2006; 22
Murai, Zhang, Morris (bib173) 2014; 349
Kioi, Husain, Croteau (bib215) 2006; 5
Wedge, Porteous, Glaser (bib78) 1997; 8
Wahl, Lawrence (bib124) 2015
Walker, Green, Byar (bib17) 1980; 303
Hegi, Diserens, Godard (bib76) 2004; 10
Seung, Curti, Crittenden (bib209) 2012; 4
Mallick, Benson, Julka (bib4) 2015; 46
Carlson, Grogan, Mladek (bib83) 2009; 75
Pollard, Gatti (bib162) 2009; 74
Quinn, Jiang, Reardon (bib86) 2009; 27
Chan, Lee, Fraass (bib30) 2002; 20
Levin, Silver, Hannigan (bib47) 1990; 18
Prados, Larson, Lamborn (bib48) 1998; 40
Bryant, Schultz, Thomas (bib171) 2005; 434
Freeman, Long, Iwai (bib190) 2000; 192
Yan, Boboila, Souza (bib161) 2007; 449
Huettner, Paulus, Roggendorf (bib97) 1995; 146
Sampson, Mitchell (bib105) 2015; 17
Levin, Bidaut, Hou (bib142) 2011; 79
Heimberger, Hlatky, Suki (bib106) 2005; 11
Rich, Reardon, Peery (bib227) 2004; 22
Ishiyama, Teh, Ren (bib200) 2012; 10
Coffey, Lunsford, Taylor (bib26) 1988; 22
Stevens, Hickman, Langdon (bib58) 1987; 47
Grupp, Kalos, Barrett (bib187) 2013; 368
Chinot, Wick, Mason (bib135) 2014; 370
Roa, Brasher, Bauman (bib205) 2004; 22
Brock, Newlands, Wedge (bib69) 1998; 58
Ramirez, Mladek, Phillips (bib88) 2015; 14
Brahmer, Tykodi, Chow (bib188) 2012; 366
Yung, Albright, Olson (bib66) 2000; 83
Douglas, Stelzer, Mankoff (bib31) 2006; 64
Oberg, Dave, Bruce (bib217) 2014; 1
Calabrese, Almassy, Barton (bib179) 2004; 96
Velic, Couturier, Ferreira (bib184) 2015; 5
Schardt, Elsässer, Schulz-Ertner (bib33) 2010; 82
Dix, Brooks, Roszman (bib90) 1999; 100
Schartner, Hagar, Van Handel (bib96) 2005; 51
Kelsey, Beaven, Diehl (bib2) 2012; 26
Friedman, Kerby, Calvert (bib73) 2000; 6
Srivastava, Raghavan (bib153) 2015; 22
Gajjar, Chintagumpala, Ashley (bib1) 2006; 7
Brada, Judson, Beale (bib62) 1999; 81
Chang, Khuntia, Robins (bib114) 2007; 5
Winkler, Kozin, Tong (bib147) 2004; 6
Grass, Krishna, Kim (bib196) 2015; 40
Friedman, Prados, Wen (bib133) 2009; 27
Watkins, Robel, Kimbrough (bib44) 2014
Suit, DeLaney, Goldberg (bib38) 2010; 95
Castro, Phillips, Prados (bib36) 1997; 38
Gilbert, Dignam, Armstrong (bib136) 2014; 370
Stummer, Pichlmeier, Meinel (bib13) 2006; 7
Belcaid, Phallen, Zeng (bib203) 2014; 9
Steel, Peckham (bib7) 1979; 5
Kaina, Margison, Christmann (bib85) 2010; 67
Kim, Chung, Kim (bib137) 2004; 19
Gebhardt, Dobelbower, Ennis (bib24) 2014; 9
Newlands, O'Reilly, Glaser (bib64) 1996; 32A
Sampson, Heimberger, Archer (bib107) 2010; 28
Iuchi, Hatano, Kodama (bib208) 2014; 88
Hiniker, Chen, Reddy (bib198) 2012; 5
Mitchell, Batich, Gunn (bib112) 2015; 519
Sawyer (bib222) 2011; 1
Ene, Holland (bib45) 2015; 6
Corso, Rutter, Park (bib5) 2015; 33
Chang, Horton, Schoenfeld (bib27) 1983; 52
van Rijn, Heimans, van den Berg (bib79) 2000; 47
Dandy (bib15) 1928; 90
Hammond, Eckardt, Baker (bib60) 1999; 17
Fu, Calvo, Samson (bib72) 2012; 12
Weller, Stupp, Reifenberger (bib75) 2010; 6
Hodi, O'Day, McDermott (bib185) 2010; 363
Stevens, Hickman, Stone (bib54) 1984; 27
Thornton, Hegarty, TenHaken (bib23) 1991; 20
Walker, Strike, Sheline (bib25) 1979; 5
Hussain, Yang, Suki (bib99) 2006; 8
Wei, Wu, Kong (bib102) 2011; 6
Garnett, Palena, Chakraborty (bib195) 2004; 64
Reardon, Freeman, Wu (bib93) 2014; 16
Phuphanich, Wheeler, Rudnick (bib111) 2013; 62
Chow, Hara, Lim (bib104) 2015; 123
Sanai, Polley, McDermott (bib9) 2011; 115
Friedman, Johnson, Dong (bib77) 1997; 57
Ceccaldi, Rondinelli, D’Andrea (bib152) 2016; 26
Kotter, Cornils, Borgmann (bib182) 2014; 8
Castro, Saunders, Austin-Seymour (bib35) 1985; 11
Mukherjee, McEllin, Camacho (bib164) 2009; 69
Postow, Callahan, Barker (bib199) 2012; 366
Torcuator, Zuniga, Mohan (bib141) 2009; 94
Yung, Vredenburgh, Cloughesy (bib226) 2010; 12
Combs, Schulz-Ertner, Roth (bib81) 2007; 68
Bloch, Raizer, Lim (bib113) 2015; 33
Mar, Desjardins, Vredenburgh (bib132) 2015; 21
Hickman, Stevens, Gibson (bib55) 1985; 45
Narayana, Yamada, Berry (bib22) 2006; 64
Stark-Vance (bib129) 2005; 7
bib183
Linsley, Greene, Brady (bib189) 1994; 1
Hurwitz, Fehrenbacher, Novotny (bib127) 2004; 350
Sarkar, Curran, Sarkaria (bib213) 2014; 9
Kreisl, Kim, Moore (bib134) 2009; 27
Gajewski, Sosman, Gerson (bib87) 2005; 11
Tang, Wang, Soh (bib191) 2014; 2
Tsai, Li, Gonzalez-Angulo (bib3) 2015; 38
Verhaak, Hoadley, Purdom (bib225) 2010; 17
Avril, Vauleon, Tanguy-Royer (bib89) 2011; 3
Schuster, Lai, Recht (bib108) 2015; 17
Arshad, Yang, Bienemann (bib221) 2015; 10
Kempuraj, Devi, Madhappan (bib92) 2004; 17
Pickles, Goodman, Rheaume (bib37) 1997; 37
Fecci, Mitchell, Whitesides (bib91) 2006; 66
Brachman, Pugh, Ashby (bib123) 2015; 91
Jacobs, Idema, Bol (bib101) 2010; 225
Roa, Kepka, Kumar (bib206) 2015; 33
Freese, O'Rourke, Judy (bib119) 1994; 20
Guirouilh-Barbat, Rass, Plo (bib159) 2007; 104
Flatmark, Ree (bib125) 2010; 28
Lieber (bib157) 2008; 283
Ciccia, Elledge (bib156) 2010; 40
Choi, Feshitan, Baseri (bib216) 2010; 57
Waziri (bib94) 2010; 21
Fitzek, Thornton, Rabinov (bib39) 1999; 91
Miller, Chap, Holmes (bib126) 2005; 23
Sandell, Zakian (bib155) 1993; 75
Walker, Alexander, Hunt (bib18) 1978; 49
Groves, Maor, Meyers (bib120) 1999; 45
Zeng, Harris, Lim (bib211) 2013; 2013
Soulas-Sprauel, Le Guyader, Rivera-Munoz (bib160) 2007; 204
Chang SM, Zhang P, Cairncross JG, et al. Results of NRG oncology/RTOG 9813: A phase III randomized study of radiation therapy (RT) and temozolomide (TMZ) versus RT and nitrosourea (NU) therapy for anaplastic astrocytoma (AA). Paper presented at: 2015 ASCO Annual Meeting, 2015.
Senft, Bink, Franz (bib12) 2011; 12
Dhodapkar, Rubin, Reid (bib61) 1997; 3
Bennett, Lewis, Baldwin (bib154) 1993; 90
Desgrosellier, Cheresh (bib150) 2010; 10
Senra, Telfer, Cherry (bib178) 2011; 10
Wallner, Galicich, Krol (bib20) 1989; 16
Neagu, Reardon (bib103) 2015; 16
Vredenburgh, Desjardins, Herndon (bib130) 2007; 25
Vredenburgh, Desjardins, Herndon (bib131) 2007; 13
Dungey, Caldecott, Chalmers (bib180) 2009; 8
Hdeib, Sloan (bib214) 2011; 11
Schumacher, Bunse, Pusch (bib229) 2014; 512
Powell, Mikropoulos, Kaye (bib177) 2010; 36
Huhn, Bolck, Sartori (bib169) 2013
Li, Suki, Hess (bib10) 2015
Anderson, Stevens, Sumption (bib34) 2007; 167
Lee, Kaley, Duda (bib148) 2015; 21
Ammirati, Chotai, Newton (bib207) 2014; 21
Bassi, Ho, Srikumar (bib163) 2013; 341
Klein, Loven, Lurie (bib194) 1994; 80
Cardinale, Dillehay, Williams (bib116) 1998; 6
Gibson, Hickman, Erickson (bib57) 1984; 44
Malmstrom, Gronberg, Marosi (bib204) 2012; 13
Medical Research Council Brain Tumor Working Party (bib52) 2001; 19
Bogdahn, Hau, Stockhammer (bib219) 2011; 13
Souhami, Seiferheld, Brachman (bib29) 2004; 60
Squatrito, Holland (bib165) 2011; 71
Sampson, Aldape, Archer (bib109) 2011; 13
O'Reilly, Newlands, Glaser (bib63) 1993; 29A
Nelson, Diener-West, Horton (bib28) 1988; 6
Farmer, McCabe, Lord (bib172) 2005; 434
Shen, Zhang (bib42) 2010; 21
Halperin, Herndon, Schold (bib49) 1996; 34
Pardridge (bib41) 1998; 70
Dungey, Loser, Chalmers (bib181) 2008; 72
Reits, Hodge, Herberts (bib192) 2006; 203
Stupp, Hegi, Gorlia (bib151) 2014; 15
TranThang, Derouazi, Philippin (bib100) 2010; 70
Zeng, See, Phallen (bib202) 2013; 86
Souhami (10.1016/j.semradonc.2016.06.003_bib29) 2004; 60
Stupp (10.1016/j.semradonc.2016.06.003_bib151) 2014; 15
Ene (10.1016/j.semradonc.2016.06.003_bib45) 2015; 6
Dungey (10.1016/j.semradonc.2016.06.003_bib180) 2009; 8
Hussain (10.1016/j.semradonc.2016.06.003_bib99) 2006; 8
Newlands (10.1016/j.semradonc.2016.06.003_bib59) 1992; 65
Chakravarti (10.1016/j.semradonc.2016.06.003_bib80) 2006; 12
Dungey (10.1016/j.semradonc.2016.06.003_bib181) 2008; 72
Roa (10.1016/j.semradonc.2016.06.003_bib206) 2015; 33
Park (10.1016/j.semradonc.2016.06.003_bib6) 2013; 60
Demaria (10.1016/j.semradonc.2016.06.003_bib193) 2005; 11
Sawyer (10.1016/j.semradonc.2016.06.003_bib222) 2011; 1
Shen (10.1016/j.semradonc.2016.06.003_bib42) 2010; 21
Mukherjee (10.1016/j.semradonc.2016.06.003_bib164) 2009; 69
Bryant (10.1016/j.semradonc.2016.06.003_bib171) 2005; 434
Medical Research Council Brain Tumor Working Party (10.1016/j.semradonc.2016.06.003_bib52) 2001; 19
Senft (10.1016/j.semradonc.2016.06.003_bib12) 2011; 12
Pickles (10.1016/j.semradonc.2016.06.003_bib37) 1997; 37
Sampson (10.1016/j.semradonc.2016.06.003_bib109) 2011; 13
Aziz (10.1016/j.semradonc.2016.06.003_bib167) 2012; 133
Del Rowe (10.1016/j.semradonc.2016.06.003_bib118) 2000; 18
Yung (10.1016/j.semradonc.2016.06.003_bib226) 2010; 12
Verhaak (10.1016/j.semradonc.2016.06.003_bib225) 2010; 17
McGee (10.1016/j.semradonc.2016.06.003_bib144) 2010; 76
Iuchi (10.1016/j.semradonc.2016.06.003_bib208) 2014; 88
10.1016/j.semradonc.2016.06.003_bib68
van Rijn (10.1016/j.semradonc.2016.06.003_bib79) 2000; 47
Tsai (10.1016/j.semradonc.2016.06.003_bib3) 2015; 38
Hdeib (10.1016/j.semradonc.2016.06.003_bib214) 2011; 11
Kelly (10.1016/j.semradonc.2016.06.003_bib14) 1987; 62
Cloughesy (10.1016/j.semradonc.2016.06.003_bib46) 2014; 9
Hickman (10.1016/j.semradonc.2016.06.003_bib55) 1985; 45
Ahmed (10.1016/j.semradonc.2016.06.003_bib166) 2015; 75
Brock (10.1016/j.semradonc.2016.06.003_bib69) 1998; 58
Kim (10.1016/j.semradonc.2016.06.003_bib137) 2004; 19
Hottinger (10.1016/j.semradonc.2016.06.003_bib146) 2014; 110
Lee (10.1016/j.semradonc.2016.06.003_bib148) 2015; 21
Zhou (10.1016/j.semradonc.2016.06.003_bib223) 2013; 110
Linsley (10.1016/j.semradonc.2016.06.003_bib189) 1994; 1
Bloch (10.1016/j.semradonc.2016.06.003_bib113) 2015; 33
Dix (10.1016/j.semradonc.2016.06.003_bib90) 1999; 100
Sampson (10.1016/j.semradonc.2016.06.003_bib105) 2015; 17
Stewart (10.1016/j.semradonc.2016.06.003_bib53) 2002; 359
Walker (10.1016/j.semradonc.2016.06.003_bib25) 1979; 5
Bennett (10.1016/j.semradonc.2016.06.003_bib154) 1993; 90
Oberg (10.1016/j.semradonc.2016.06.003_bib217) 2014; 1
Corneo (10.1016/j.semradonc.2016.06.003_bib158) 2007; 449
Schartner (10.1016/j.semradonc.2016.06.003_bib96) 2005; 51
Gibson (10.1016/j.semradonc.2016.06.003_bib57) 1984; 44
Powell (10.1016/j.semradonc.2016.06.003_bib177) 2010; 36
Groves (10.1016/j.semradonc.2016.06.003_bib120) 1999; 45
Lieber (10.1016/j.semradonc.2016.06.003_bib157) 2008; 283
Yung (10.1016/j.semradonc.2016.06.003_bib67) 1999; 17
Newlands (10.1016/j.semradonc.2016.06.003_bib56) 1985; 69
Stupp (10.1016/j.semradonc.2016.06.003_bib40) 2005; 352
Chang (10.1016/j.semradonc.2016.06.003_bib114) 2007; 5
Lacroix (10.1016/j.semradonc.2016.06.003_bib8) 2001; 95
Heimberger (10.1016/j.semradonc.2016.06.003_bib106) 2005; 11
Rich (10.1016/j.semradonc.2016.06.003_bib227) 2004; 22
Chinot (10.1016/j.semradonc.2016.06.003_bib135) 2014; 370
Levin (10.1016/j.semradonc.2016.06.003_bib142) 2011; 79
Huettner (10.1016/j.semradonc.2016.06.003_bib97) 1995; 146
Squatrito (10.1016/j.semradonc.2016.06.003_bib165) 2011; 71
Thornton (10.1016/j.semradonc.2016.06.003_bib23) 1991; 20
Hodi (10.1016/j.semradonc.2016.06.003_bib185) 2010; 363
Hiniker (10.1016/j.semradonc.2016.06.003_bib198) 2012; 5
Gilbert (10.1016/j.semradonc.2016.06.003_bib84) 2013; 31
Sanai (10.1016/j.semradonc.2016.06.003_bib9) 2011; 115
Mar (10.1016/j.semradonc.2016.06.003_bib132) 2015; 21
Steel (10.1016/j.semradonc.2016.06.003_bib7) 1979; 5
Schaue (10.1016/j.semradonc.2016.06.003_bib210) 2012; 83
Kreisl (10.1016/j.semradonc.2016.06.003_bib134) 2009; 27
Hopkins (10.1016/j.semradonc.2016.06.003_bib175) 2015; 13
Mitchell (10.1016/j.semradonc.2016.06.003_bib112) 2015; 519
Coffey (10.1016/j.semradonc.2016.06.003_bib26) 1988; 22
Srivastava (10.1016/j.semradonc.2016.06.003_bib153) 2015; 22
Phuphanich (10.1016/j.semradonc.2016.06.003_bib111) 2013; 62
Sarkar (10.1016/j.semradonc.2016.06.003_bib213) 2014; 9
Avril (10.1016/j.semradonc.2016.06.003_bib89) 2011; 3
Klein (10.1016/j.semradonc.2016.06.003_bib194) 1994; 80
Schumacher (10.1016/j.semradonc.2016.06.003_bib229) 2014; 512
Hochberg (10.1016/j.semradonc.2016.06.003_bib19) 1980; 30
Prados (10.1016/j.semradonc.2016.06.003_bib121) 2004; 58
Farmer (10.1016/j.semradonc.2016.06.003_bib172) 2005; 434
Velic (10.1016/j.semradonc.2016.06.003_bib184) 2015; 5
Hammond (10.1016/j.semradonc.2016.06.003_bib60) 1999; 17
TranThang (10.1016/j.semradonc.2016.06.003_bib100) 2010; 70
Andersen (10.1016/j.semradonc.2016.06.003_bib16) 1978; 17
Flatmark (10.1016/j.semradonc.2016.06.003_bib125) 2010; 28
Ramirez (10.1016/j.semradonc.2016.06.003_bib88) 2015; 14
Vredenburgh (10.1016/j.semradonc.2016.06.003_bib130) 2007; 25
Castro (10.1016/j.semradonc.2016.06.003_bib36) 1997; 38
Liang (10.1016/j.semradonc.2016.06.003_bib21) 1991; 75
Fecci (10.1016/j.semradonc.2016.06.003_bib91) 2006; 66
Brachman (10.1016/j.semradonc.2016.06.003_bib123) 2015; 91
Walker (10.1016/j.semradonc.2016.06.003_bib17) 1980; 303
Gordon (10.1016/j.semradonc.2016.06.003_bib128) 2001; 19
Stark-Vance (10.1016/j.semradonc.2016.06.003_bib129) 2005; 7
Schuster (10.1016/j.semradonc.2016.06.003_bib108) 2015; 17
Quinn (10.1016/j.semradonc.2016.06.003_bib86) 2009; 27
Postow (10.1016/j.semradonc.2016.06.003_bib199) 2012; 366
Nonoguchi (10.1016/j.semradonc.2016.06.003_bib138) 2011; 105
Bower (10.1016/j.semradonc.2016.06.003_bib65) 1997; 40
Wallner (10.1016/j.semradonc.2016.06.003_bib20) 1989; 16
Fitzek (10.1016/j.semradonc.2016.06.003_bib39) 1999; 91
Sawamura (10.1016/j.semradonc.2016.06.003_bib98) 1990; 9
Denny (10.1016/j.semradonc.2016.06.003_bib71) 1994; 33
Sampson (10.1016/j.semradonc.2016.06.003_bib107) 2010; 28
Schnell (10.1016/j.semradonc.2016.06.003_bib149) 2008; 18
Huhn (10.1016/j.semradonc.2016.06.003_bib169) 2013
Hegi (10.1016/j.semradonc.2016.06.003_bib76) 2004; 10
Rouleau (10.1016/j.semradonc.2016.06.003_bib170) 2010; 10
Corso (10.1016/j.semradonc.2016.06.003_bib5) 2015; 33
Winkler (10.1016/j.semradonc.2016.06.003_bib147) 2004; 6
Chow (10.1016/j.semradonc.2016.06.003_bib104) 2015; 123
Gebhardt (10.1016/j.semradonc.2016.06.003_bib24) 2014; 9
Gilbert (10.1016/j.semradonc.2016.06.003_bib136) 2014; 370
Boothe (10.1016/j.semradonc.2016.06.003_bib140) 2013; 15
Narayana (10.1016/j.semradonc.2016.06.003_bib22) 2006; 64
Levin (10.1016/j.semradonc.2016.06.003_bib47) 1990; 18
Weller (10.1016/j.semradonc.2016.06.003_bib75) 2010; 6
Curtin (10.1016/j.semradonc.2016.06.003_bib168) 2012; 12
Brahmer (10.1016/j.semradonc.2016.06.003_bib188) 2012; 366
Torcuator (10.1016/j.semradonc.2016.06.003_bib141) 2009; 94
Kantoff (10.1016/j.semradonc.2016.06.003_bib186) 2010; 363
Combs (10.1016/j.semradonc.2016.06.003_bib81) 2007; 68
Kempuraj (10.1016/j.semradonc.2016.06.003_bib92) 2004; 17
Miller (10.1016/j.semradonc.2016.06.003_bib126) 2005; 23
Dandy (10.1016/j.semradonc.2016.06.003_bib15) 1928; 90
Kioi (10.1016/j.semradonc.2016.06.003_bib215) 2006; 5
Malmstrom (10.1016/j.semradonc.2016.06.003_bib204) 2012; 13
Kotter (10.1016/j.semradonc.2016.06.003_bib182) 2014; 8
Zeng (10.1016/j.semradonc.2016.06.003_bib211) 2013; 2013
Waziri (10.1016/j.semradonc.2016.06.003_bib94) 2010; 21
Yan (10.1016/j.semradonc.2016.06.003_bib161) 2007; 449
Desgrosellier (10.1016/j.semradonc.2016.06.003_bib150) 2010; 10
Suit (10.1016/j.semradonc.2016.06.003_bib38) 2010; 95
Garnett (10.1016/j.semradonc.2016.06.003_bib195) 2004; 64
Kunwar (10.1016/j.semradonc.2016.06.003_bib220) 2010; 12
Grupp (10.1016/j.semradonc.2016.06.003_bib187) 2013; 368
Patel (10.1016/j.semradonc.2016.06.003_bib218) 2005; 56
Gajewski (10.1016/j.semradonc.2016.06.003_bib87) 2005; 11
Stevens (10.1016/j.semradonc.2016.06.003_bib54) 1984; 27
Stevens (10.1016/j.semradonc.2016.06.003_bib58) 1987; 47
Oberoi (10.1016/j.semradonc.2016.06.003_bib43) 2016; 18
Vredenburgh (10.1016/j.semradonc.2016.06.003_bib131) 2007; 13
Wahl (10.1016/j.semradonc.2016.06.003_bib124) 2015
Friedman (10.1016/j.semradonc.2016.06.003_bib73) 2000; 6
Reardon (10.1016/j.semradonc.2016.06.003_bib93) 2014; 16
Prados (10.1016/j.semradonc.2016.06.003_bib48) 1998; 40
Castro (10.1016/j.semradonc.2016.06.003_bib35) 1985; 11
Nelson (10.1016/j.semradonc.2016.06.003_bib28) 1988; 6
Freeman (10.1016/j.semradonc.2016.06.003_bib190) 2000; 192
Guirouilh-Barbat (10.1016/j.semradonc.2016.06.003_bib159) 2007; 104
Watkins (10.1016/j.semradonc.2016.06.003_bib44) 2014
Ciccia (10.1016/j.semradonc.2016.06.003_bib156) 2010; 40
Brada (10.1016/j.semradonc.2016.06.003_bib62) 1999; 81
O'Reilly (10.1016/j.semradonc.2016.06.003_bib63) 1993; 29A
Stupp (10.1016/j.semradonc.2016.06.003_bib70) 2002; 20
Friedman (10.1016/j.semradonc.2016.06.003_bib133) 2009; 27
Tang (10.1016/j.semradonc.2016.06.003_bib191) 2014; 2
Fu (10.1016/j.semradonc.2016.06.003_bib72) 2012; 12
Ceccaldi (10.1016/j.semradonc.2016.06.003_bib152) 2016; 26
Choi (10.1016/j.semradonc.2016.06.003_bib216) 2010; 57
Seung (10.1016/j.semradonc.2016.06.003_bib209) 2012; 4
Wedge (10.1016/j.semradonc.2016.06.003_bib78) 1997; 8
Soulas-Sprauel (10.1016/j.semradonc.2016.06.003_bib160) 2007; 204
Zeman (10.1016/j.semradonc.2016.06.003_bib115) 1986; 12
Scaringi (10.1016/j.semradonc.2016.06.003_bib143) 2013; 6
Jacobs (10.1016/j.semradonc.2016.06.003_bib101) 2010; 225
Carlson (10.1016/j.semradonc.2016.06.003_bib83) 2009; 75
Cardinale (10.1016/j.semradonc.2016.06.003_bib116) 1998; 6
Murai (10.1016/j.semradonc.2016.06.003_bib173) 2014; 349
Li (10.1016/j.semradonc.2016.06.003_bib10) 2015
Gupta (10.1016/j.semradonc.2016.06.003_bib145) 2002; 8
Chan (10.1016/j.semradonc.2016.06.003_bib30) 2002; 20
Rieken (10.1016/j.semradonc.2016.06.003_bib32) 2012; 7
Zeng (10.1016/j.semradonc.2016.06.003_bib202) 2013; 86
Chang (10.1016/j.semradonc.2016.06.003_b
References_xml – start-page: 143
  year: 2013
  ident: bib169
  article-title: Targeting DNA double-strand break signalling and repair: Recent advances in cancer therapy
  publication-title: Swiss Med Wkly
– volume: 75
  start-page: 4416
  year: 2015
  end-page: 4428
  ident: bib166
  article-title: Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells
  publication-title: Cancer Res
– volume: 38
  start-page: 242
  year: 2015
  end-page: 247
  ident: bib3
  article-title: Outcomes after multidisciplinary treatment of inflammatory breast cancer in the era of neoadjuvant HER2-directed therapy
  publication-title: Am J Clin Oncol
– volume: 25
  start-page: 4722
  year: 2007
  end-page: 4729
  ident: bib130
  article-title: Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
  publication-title: J Clin Oncol
– volume: 69
  start-page: 1246
  year: 2007
  end-page: 1253
  ident: bib82
  article-title: Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 21
  start-page: 633
  year: 2014
  end-page: 637
  ident: bib207
  article-title: Hypofractionated intensity modulated radiotherapy with temozolomide in newly diagnosed glioblastoma multiforme
  publication-title: J Clin Neurosci
– volume: 31
  start-page: 4085
  year: 2013
  end-page: 4091
  ident: bib84
  article-title: Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial
  publication-title: J Clin Oncol
– volume: 45
  start-page: 3008
  year: 1985
  end-page: 3013
  ident: bib55
  article-title: Experimental antitumor activity against murine tumor model systems of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one (mitozolomide), a novel broad-spectrum agent
  publication-title: Cancer Res
– volume: 23
  start-page: 792
  year: 2005
  end-page: 799
  ident: bib126
  article-title: Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
  publication-title: J Clin Oncol
– volume: 27
  start-page: 4733
  year: 2009
  end-page: 4740
  ident: bib133
  article-title: Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
  publication-title: J Clin Oncol
– volume: 81
  start-page: 1022
  year: 1999
  end-page: 1030
  ident: bib62
  article-title: Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies
  publication-title: Br J Cancer
– volume: 17
  start-page: 2762
  year: 1999
  end-page: 2771
  ident: bib67
  article-title: Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group
  publication-title: J Clin Oncol
– volume: 133
  start-page: 334
  year: 2012
  end-page: 350
  ident: bib167
  article-title: Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy
  publication-title: Pharmacol Ther
– volume: 11
  start-page: 1795
  year: 1985
  end-page: 1800
  ident: bib35
  article-title: A phase I-II trial of heavy charged particle irradiation of malignant glioma of the brain: A Northern California Oncology Group Study
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 449
  start-page: 483
  year: 2007
  end-page: 486
  ident: bib158
  article-title: Rag mutations reveal robust alternative end joining
  publication-title: Nature
– volume: 71
  start-page: 1
  year: 1989
  end-page: 9
  ident: bib51
  article-title: Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001
  publication-title: J Neurosurg
– volume: 13
  start-page: 433
  year: 2014
  end-page: 443
  ident: bib174
  article-title: Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib
  publication-title: Mol Cancer Ther
– volume: 37
  start-page: 491
  year: 1997
  end-page: 497
  ident: bib37
  article-title: Pion radiation for high grade astrocytoma: Results of a randomized study
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 21
  start-page: 29
  year: 2010
  end-page: 53
  ident: bib42
  article-title: ABC transporters and drug efflux at the blood-brain barrier
  publication-title: Rev Neurosci
– volume: 204
  start-page: 1717
  year: 2007
  end-page: 1727
  ident: bib160
  article-title: Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination
  publication-title: J Exp Med
– volume: 19
  start-page: 509
  year: 2001
  end-page: 518
  ident: bib52
  article-title: Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: A Medical Research Council trial
  publication-title: J Clin Oncol
– volume: 9
  start-page: 125
  year: 1990
  end-page: 130
  ident: bib98
  article-title: In vitro prostaglandin E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes
  publication-title: J Neurooncol
– volume: 21
  start-page: 31
  year: 2010
  end-page: 42
  ident: bib94
  article-title: Glioblastoma-derived mechanisms of systemic immunosuppression
  publication-title: Neurosurg Clin N Am
– volume: 80
  start-page: 1074
  year: 1994
  end-page: 1077
  ident: bib194
  article-title: The effect of irradiation on expression of HLA class I antigens in human brain tumors in culture
  publication-title: J Neurosurg
– volume: 341
  start-page: 395
  year: 2013
  end-page: 399
  ident: bib163
  article-title: Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
  publication-title: Science
– volume: 40
  start-page: 10
  year: 2015
  end-page: 24
  ident: bib196
  article-title: The immune mechanisms of abscopal effect in radiation therapy
  publication-title: Curr Probl Cancer
– volume: 11
  start-page: 799
  year: 2011
  end-page: 806
  ident: bib214
  article-title: Convection-enhanced delivery of 131I-chTNT-1/B mAB for treatment of high-grade adult gliomas
  publication-title: Expert Opin Biol Ther
– volume: 22
  start-page: 465
  year: 1988
  end-page: 473
  ident: bib26
  article-title: Survival after stereotactic biopsy of malignant gliomas
  publication-title: Neurosurgery
– volume: 104
  start-page: 20902
  year: 2007
  end-page: 20907
  ident: bib159
  article-title: Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
  publication-title: Proc Natl Acad Sci U S A
– volume: 11
  start-page: 8304
  year: 2005
  end-page: 8311
  ident: bib95
  article-title: Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors
  publication-title: Clin Cancer Res
– volume: 27
  start-page: 740
  year: 2009
  end-page: 745
  ident: bib134
  article-title: Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
  publication-title: J Clin Oncol
– volume: 28
  start-page: 4722
  year: 2010
  end-page: 4729
  ident: bib107
  article-title: Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
  publication-title: J Clin Oncol
– volume: 10
  start-page: e0132266
  year: 2015
  ident: bib221
  article-title: Convection-enhanced delivery of carboplatin PLGA nanoparticles for the treatment of glioblastoma
  publication-title: PLoS One
– volume: 105
  start-page: 423
  year: 2011
  end-page: 431
  ident: bib138
  article-title: The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: Pathological consideration of their potential roles
  publication-title: J Neurooncol
– volume: 90
  start-page: 5613
  year: 1993
  end-page: 5617
  ident: bib154
  article-title: Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid
  publication-title: Proc Natl Acad Sci U S A
– volume: 76
  start-page: 1537
  year: 2010
  end-page: 1545
  ident: bib144
  article-title: Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 22
  start-page: 501
  year: 2006
  end-page: 510
  ident: bib74
  article-title: ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
  publication-title: Mol Cell
– volume: 86
  start-page: 343
  year: 2013
  end-page: 349
  ident: bib202
  article-title: Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 7
  start-page: 369
  year: 2005
  ident: bib129
  article-title: Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma (abstract)
  publication-title: Neuro Oncol
– volume: 434
  start-page: 917
  year: 2005
  end-page: 921
  ident: bib172
  article-title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
  publication-title: Nature
– volume: 62
  start-page: 450
  year: 1987
  end-page: 459
  ident: bib14
  article-title: Stereotactic histologic correlations of computed tomography- and magnetic resonance imaging-defined abnormalities in patients with glial neoplasms
  publication-title: Mayo Clin Proc
– volume: 6
  start-page: e16195
  year: 2011
  ident: bib102
  article-title: Hypoxia potentiates glioma-mediated immunosuppression
  publication-title: PLoS One
– volume: 12
  start-page: 1239
  year: 1986
  end-page: 1242
  ident: bib115
  article-title: SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
  publication-title: Int J Radiat Oncol Biol Phys
– reference: Chang SM, Zhang P, Cairncross JG, et al. Results of NRG oncology/RTOG 9813: A phase III randomized study of radiation therapy (RT) and temozolomide (TMZ) versus RT and nitrosourea (NU) therapy for anaplastic astrocytoma (AA). Paper presented at: 2015 ASCO Annual Meeting, 2015.
– volume: 283
  start-page: 1
  year: 2008
  end-page: 5
  ident: bib157
  article-title: The mechanism of human nonhomologous DNA end joining
  publication-title: J Biol Chem
– volume: 19
  start-page: 843
  year: 2001
  end-page: 850
  ident: bib128
  article-title: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
  publication-title: J Clin Oncol
– volume: 90
  start-page: 823
  year: 1928
  end-page: 825
  ident: bib15
  article-title: Removal of right cerebral hemisphere for certain tumors with hemiplegia: Preliminary report
  publication-title: J Am Med Assoc
– volume: 11
  start-page: 728
  year: 2005
  end-page: 734
  ident: bib193
  article-title: Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
  publication-title: Clin Cancer Res
– volume: 47
  start-page: 779
  year: 2000
  end-page: 784
  ident: bib79
  article-title: Survival of human glioma cells treated with various combination of temozolomide and X-rays
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 22
  start-page: 133
  year: 2004
  end-page: 142
  ident: bib227
  article-title: Phase II trial of gefitinib in recurrent glioblastoma
  publication-title: J Clin Oncol
– volume: 44
  start-page: 1772
  year: 1984
  end-page: 1775
  ident: bib57
  article-title: DNA cross-linking and cytotoxicity in normal and transformed human cells treated in vitro with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one
  publication-title: Cancer Res
– volume: 18
  start-page: 378
  year: 2008
  end-page: 386
  ident: bib149
  article-title: Expression of integrin αvβ3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature
  publication-title: Brain Pathol
– volume: 449
  start-page: 478
  year: 2007
  end-page: 482
  ident: bib161
  article-title: IgH class switching and translocations use a robust non-classical end-joining pathway
  publication-title: Nature
– volume: 7
  start-page: 813
  year: 2006
  end-page: 820
  ident: bib1
  article-title: Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): Long-term results from a prospective, multicentre trial
  publication-title: Lancet Oncol
– volume: 26
  start-page: 1182
  year: 2012
  end-page: 1189
  ident: bib2
  article-title: Combined-modality therapy for early-stage Hodgkin lymphoma: Maintaining high cure rates while minimizing risks
  publication-title: Oncology (Williston Park)
– volume: 352
  start-page: 987
  year: 2005
  end-page: 996
  ident: bib40
  article-title: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
  publication-title: N Engl J Med
– volume: 18
  start-page: 1254
  year: 2000
  end-page: 1259
  ident: bib118
  article-title: Single-arm, open-label phase II study of intravenously administered tirapazamine and radiation therapy for glioblastoma multiforme
  publication-title: J Clin Oncol
– volume: 100
  start-page: 216
  year: 1999
  end-page: 232
  ident: bib90
  article-title: Immune defects observed in patients with primary malignant brain tumors
  publication-title: J Neuroimmunol
– volume: 33
  start-page: 4240
  year: 2015
  end-page: 4246
  ident: bib5
  article-title: Role of chemoradiotherapy in elderly patients with limited-stage small-cell lung cancer
  publication-title: J Clin Oncol
– volume: 13
  start-page: 1465
  year: 2015
  end-page: 1477
  ident: bib175
  article-title: Mechanistic dissection of PARP1 trapping and the impact on in vivo tolerability and efficacy of PARP inhibitors
  publication-title: Mol Cancer Res
– volume: 16
  start-page: 54
  year: 2015
  ident: bib103
  article-title: An update on the role of immunotherapy and vaccine strategies for primary brain tumors
  publication-title: Curr Treat Options Oncol
– volume: 6
  start-page: 279
  year: 1988
  end-page: 284
  ident: bib28
  article-title: Combined modality approach to treatment of malignant gliomas—Re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up: A joint study of the Radiation Therapy Oncology Group and the Eastern Cooperative Oncology Group
  publication-title: NCI Monogr
– volume: 1
  start-page: 94
  year: 2014
  end-page: 100
  ident: bib217
  article-title: Neurocognitive functioning and quality of life in patients with recurrent malignant gliomas treated on a phase Ib trial evaluating topotecan by convection-enhanced delivery
  publication-title: Neurooncol Pract
– volume: 14
  start-page: 111
  year: 2015
  end-page: 119
  ident: bib88
  article-title: Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth
  publication-title: Mol Cancer Ther
– volume: 70
  start-page: 1781
  year: 1998
  end-page: 1792
  ident: bib41
  article-title: CNS drug design based on principles of blood-brain barrier transport
  publication-title: J Neurochem
– volume: 69
  start-page: 4252
  year: 2009
  end-page: 4259
  ident: bib164
  article-title: EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma
  publication-title: Cancer Res
– volume: 366
  start-page: 2455
  year: 2012
  end-page: 2465
  ident: bib188
  article-title: Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
  publication-title: N Engl J Med
– volume: 13
  start-page: 132
  year: 2011
  end-page: 142
  ident: bib219
  article-title: Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
  publication-title: Neuro Oncol
– volume: 95
  start-page: 190
  year: 2001
  end-page: 198
  ident: bib8
  article-title: A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival
  publication-title: J Neurosurg
– volume: 5
  start-page: 239
  year: 2006
  end-page: 250
  ident: bib215
  article-title: Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy
  publication-title: Technol Cancer Res Treat
– start-page: 1
  year: 2015
  end-page: 12
  ident: bib10
  article-title: The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection?
  publication-title: J Neurosurg
– volume: 10
  start-page: 1949
  year: 2011
  end-page: 1958
  ident: bib178
  article-title: Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft
  publication-title: Mol Cancer Ther
– volume: 8
  start-page: 261
  year: 2006
  end-page: 279
  ident: bib99
  article-title: The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
  publication-title: Neuro Oncol
– volume: 512
  start-page: 324
  year: 2014
  end-page: 327
  ident: bib229
  article-title: A vaccine targeting mutant IDH1 induces antitumour immunity
  publication-title: Nature
– volume: 17
  start-page: 854
  year: 2015
  end-page: 861
  ident: bib108
  article-title: A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: The ACT III study
  publication-title: Neuro Oncol
– volume: 2013
  start-page: 658126
  year: 2013
  ident: bib211
  article-title: Immune modulation and stereotactic radiation: Improving local and abscopal responses
  publication-title: Biomed Res Int
– volume: 60
  start-page: 853
  year: 2004
  end-page: 860
  ident: bib29
  article-title: Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: Report of Radiation Therapy Oncology Group 93-05 protocol
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 32A
  start-page: 2236
  year: 1996
  end-page: 2241
  ident: bib64
  article-title: The Charing Cross Hospital experience with temozolomide in patients with gliomas
  publication-title: Eur J Cancer
– volume: 46
  start-page: 1
  year: 2015
  end-page: 4
  ident: bib4
  article-title: Shifting paradigm in the management of anal canal carcinoma
  publication-title: J Gastrointest Cancer
– volume: 8
  start-page: 47
  year: 2002
  end-page: 54
  ident: bib145
  article-title: Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance
  publication-title: Cancer J
– volume: 6
  start-page: 39
  year: 2010
  end-page: 51
  ident: bib75
  article-title: MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
  publication-title: Nat Rev Neurol
– volume: 13
  start-page: 916
  year: 2012
  end-page: 926
  ident: bib204
  article-title: Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
  publication-title: Lancet Oncol
– volume: 363
  start-page: 711
  year: 2010
  end-page: 723
  ident: bib185
  article-title: Improved survival with ipilimumab in patients with metastatic melanoma
  publication-title: N Engl J Med
– volume: 9
  year: 2014
  ident: bib213
  article-title: Peptide carrier-mediated non-covalent delivery of unmodified cisplatin, methotrexate and other agents via intravenous route to the brain
  publication-title: PLoS One
– volume: 17
  start-page: vii15
  year: 2015
  end-page: vii25
  ident: bib105
  article-title: Vaccination strategies for neuro-oncology
  publication-title: Neuro Oncol
– volume: 3
  start-page: 1093
  year: 1997
  end-page: 1100
  ident: bib61
  article-title: Phase I trial of temozolomide (NSC 362856) in patients with advanced cancer
  publication-title: Clin Cancer Res
– volume: 12
  start-page: 1061
  year: 2010
  end-page: 1070
  ident: bib226
  article-title: Safety and efficacy of erlotinib in first-relapse glioblastoma: A phase II open-label study
  publication-title: Neuro Oncol
– volume: 203
  start-page: 1259
  year: 2006
  end-page: 1271
  ident: bib192
  article-title: Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
  publication-title: J Exp Med
– volume: 2
  start-page: 831
  year: 2014
  end-page: 838
  ident: bib191
  article-title: Combining radiation and immunotherapy: A new systemic therapy for solid tumors? Cancer
  publication-title: Immunol Res
– volume: 6
  start-page: 1079
  year: 2013
  end-page: 1095
  ident: bib143
  article-title: Combining molecular targeted agents with radiation therapy for malignant gliomas
  publication-title: Onco Targets Ther
– volume: 79
  start-page: 1487
  year: 2011
  end-page: 1495
  ident: bib142
  article-title: Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 370
  start-page: 709
  year: 2014
  end-page: 722
  ident: bib135
  article-title: Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
  publication-title: N Engl J Med
– volume: 20
  start-page: 3730
  year: 2014
  end-page: 3741
  ident: bib176
  article-title: Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus-resistant glioblastoma multiforme xenografts
  publication-title: Clin Cancer Res
– volume: 64
  start-page: 892
  year: 2006
  end-page: 897
  ident: bib22
  article-title: Intensity-modulated radiotherapy in high-grade gliomas: Clinical and dosimetric results
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 6
  start-page: 2585
  year: 2000
  end-page: 2597
  ident: bib73
  article-title: Temozolomide and treatment of malignant glioma
  publication-title: Clin Cancer Res
– volume: 20
  start-page: 1309
  year: 1991
  end-page: 1315
  ident: bib23
  article-title: Three-dimensional treatment planning of astrocytomas: A dosimetric study of cerebral irradiation
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 28
  start-page: e577
  year: 2010
  end-page: e578
  ident: bib125
  article-title: Radiosensitizing drugs: Lessons to be learned from the oxaliplatin story
  publication-title: J Clin Oncol
– volume: 64
  start-page: 886
  year: 2006
  end-page: 891
  ident: bib31
  article-title: [F-18]-fluorodeoxyglucose positron emission tomography for targeting radiation dose escalation for patients with glioblastoma multiforme: Clinical outcomes and patterns of failure
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 9
  start-page: 130
  year: 2014
  ident: bib24
  article-title: Patterns of failure for glioblastoma multiforme following limited-margin radiation and concurrent temozolomide
  publication-title: Radiat Oncol
– volume: 58
  start-page: 4363
  year: 1998
  end-page: 4367
  ident: bib69
  article-title: Phase I trial of temozolomide using an extended continuous oral schedule
  publication-title: Cancer Res
– volume: 16
  start-page: 1405
  year: 1989
  end-page: 1409
  ident: bib20
  article-title: Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 1
  start-page: 365
  year: 2013
  end-page: 372
  ident: bib197
  article-title: An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
  publication-title: Cancer Immunol Res
– volume: 64
  start-page: 7985
  year: 2004
  end-page: 7994
  ident: bib195
  article-title: Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes
  publication-title: Cancer Res
– volume: 16
  start-page: 1441
  year: 2014
  end-page: 1458
  ident: bib93
  article-title: Immunotherapy advances for glioblastoma
  publication-title: Neuro Oncol
– volume: 91
  start-page: 961
  year: 2015
  end-page: 967
  ident: bib123
  article-title: Phase 1/2 trials of Temozolomide, Motexafin Gadolinium, and 60-Gy fractionated radiation for newly diagnosed supratentorial glioblastoma multiforme: Final results of RTOG 0513
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 30
  start-page: 907
  year: 1980
  end-page: 911
  ident: bib19
  article-title: Assumptions in the radiotherapy of glioblastoma
  publication-title: Neurology
– volume: 34
  start-page: 793
  year: 1996
  end-page: 802
  ident: bib49
  article-title: A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 7
  start-page: 41
  year: 2012
  ident: bib32
  article-title: Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT): Early treatment results and study concepts
  publication-title: Radiat Oncol
– volume: 20
  start-page: 151
  year: 1991
  end-page: 156
  ident: bib117
  article-title: SR 4233: A tumor specific radiosensitizer active in fractionated radiation regimes
  publication-title: Radiother Oncol
– volume: 12
  start-page: 871
  year: 2010
  end-page: 881
  ident: bib220
  article-title: Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma
  publication-title: Neuro Oncol
– volume: 12
  start-page: 4738
  year: 2006
  end-page: 4746
  ident: bib80
  article-title: Temozolomide-mediated radiation enhancement in glioblastoma: A report on underlying mechanisms
  publication-title: Clin Cancer Res
– volume: 57
  start-page: 2933
  year: 1997
  end-page: 2936
  ident: bib77
  article-title: Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft
  publication-title: Cancer Res
– volume: 12
  start-page: 104
  year: 2012
  end-page: 120
  ident: bib72
  article-title: Balancing repair and tolerance of DNA damage caused by alkylating agents
  publication-title: Nat Rev Cancer
– volume: 40
  start-page: 484
  year: 1997
  end-page: 488
  ident: bib65
  article-title: Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma
  publication-title: Cancer Chemother Pharmacol
– volume: 110
  start-page: 2655
  year: 2014
  end-page: 2661
  ident: bib146
  article-title: Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma
  publication-title: Br J Cancer
– volume: 83
  start-page: 588
  year: 2000
  end-page: 593
  ident: bib66
  article-title: A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse
  publication-title: Br J Cancer
– volume: 72
  start-page: 1188
  year: 2008
  end-page: 1197
  ident: bib181
  article-title: Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: Mechanisms and therapeutic potential
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 58
  start-page: 1147
  year: 2004
  end-page: 1152
  ident: bib121
  article-title: Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: Final report of RTOG 9404
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 24
  start-page: 3117
  year: 2013
  end-page: 3123
  ident: bib11
  article-title: Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapy
  publication-title: Ann Oncol
– volume: 519
  start-page: 366
  year: 2015
  end-page: 369
  ident: bib112
  article-title: Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients
  publication-title: Nature
– volume: 9
  start-page: 1
  year: 2014
  end-page: 25
  ident: bib46
  article-title: Glioblastoma: From molecular pathology to targeted treatment
  publication-title: Annu Rev Pathol
– volume: 65
  start-page: 287
  year: 1992
  end-page: 291
  ident: bib59
  article-title: Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  publication-title: Br J Cancer
– volume: 11
  start-page: 1462
  year: 2005
  end-page: 1466
  ident: bib106
  article-title: Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
  publication-title: Clin Cancer Res
– volume: 110
  start-page: 11751
  year: 2013
  end-page: 11756
  ident: bib223
  article-title: Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
  publication-title: Proc Natl Acad Sci U S A
– volume: 40
  start-page: 57
  year: 1998
  end-page: 63
  ident: bib48
  article-title: Radiation therapy and hydroxyurea followed by the combination of 6-thioguanine and BCNU for the treatment of primary malignant brain tumors
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 33
  start-page: 9045
  year: 1994
  end-page: 9051
  ident: bib71
  article-title: NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
  publication-title: Biochemistry
– volume: 22
  start-page: 1583
  year: 2004
  end-page: 1588
  ident: bib205
  article-title: Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial
  publication-title: J Clin Oncol
– volume: 70
  start-page: 4829
  year: 2010
  end-page: 4839
  ident: bib100
  article-title: Immune infiltration of spontaneous mouse astrocytomas is dominated by immunosuppressive cells from early stages of tumor development
  publication-title: Cancer Res
– volume: 69
  start-page: 831
  year: 2007
  end-page: 838
  ident: bib122
  article-title: Results of the phase I dose-escalating study of motexafin gadolinium with standard radiotherapy in patients with glioblastoma multiforme
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 75
  start-page: 729
  year: 1993
  end-page: 739
  ident: bib155
  article-title: Loss of a yeast telomere: Arrest, recovery, and chromosome loss
  publication-title: Cell
– volume: 4
  start-page: 137ra74
  year: 2012
  ident: bib209
  article-title: Phase 1 study of stereotactic body radiotherapy and interleukin-2—Tumor and immunological responses
  publication-title: Sci Transl Med
– volume: 18
  start-page: 321
  year: 1990
  end-page: 324
  ident: bib47
  article-title: Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 13
  start-page: 324
  year: 2011
  end-page: 333
  ident: bib109
  article-title: Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma
  publication-title: Neuro Oncol
– volume: 67
  start-page: 3663
  year: 2010
  end-page: 3681
  ident: bib85
  article-title: Targeting O(6)-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy
  publication-title: Cell Mol Life Sci
– volume: 91
  start-page: 251
  year: 1999
  end-page: 260
  ident: bib39
  article-title: Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: Results of a phase II prospective trial
  publication-title: J Neurosurg
– volume: 17
  start-page: 475
  year: 1978
  end-page: 484
  ident: bib16
  article-title: Postoperative irradiation of glioblastomas. Results in a randomized series
  publication-title: Acta Radiol Oncol Radiat Phys Biol
– volume: 56
  start-page: 1243
  year: 2005
  end-page: 1252
  ident: bib218
  article-title: Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: Initial experience in 51 patients
  publication-title: Neurosurgery
– volume: 17
  start-page: 2604
  year: 1999
  end-page: 2613
  ident: bib60
  article-title: Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies
  publication-title: J Clin Oncol
– volume: 19
  start-page: 879
  year: 2004
  end-page: 886
  ident: bib137
  article-title: Upregulation of VEGF and FGF2 in normal rat brain after experimental intraoperative radiation therapy
  publication-title: J Korean Med Sci
– volume: 368
  start-page: 1509
  year: 2013
  end-page: 1518
  ident: bib187
  article-title: Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
  publication-title: N Engl J Med
– volume: 1
  start-page: 793
  year: 1994
  end-page: 801
  ident: bib189
  article-title: Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
  publication-title: Immunity
– volume: 5
  start-page: 404
  year: 2012
  end-page: 407
  ident: bib198
  article-title: A systemic complete response of metastatic melanoma to local radiation and immunotherapy
  publication-title: Transl Oncol
– volume: 366
  start-page: 925
  year: 2012
  end-page: 931
  ident: bib199
  article-title: Immunologic correlates of the abscopal effect in a patient with melanoma
  publication-title: N Engl J Med
– volume: 8
  start-page: 1616
  year: 2014
  end-page: 1625
  ident: bib182
  article-title: Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells
  publication-title: Mol Oncol
– volume: 7
  start-page: 392
  year: 2006
  end-page: 401
  ident: bib13
  article-title: Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial
  publication-title: Lancet Oncol
– volume: 38
  start-page: 257
  year: 1997
  end-page: 261
  ident: bib36
  article-title: Neon heavy charged particle radiotherapy of glioblastoma of the brain
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 9
  start-page: e101764
  year: 2014
  ident: bib203
  article-title: Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model
  publication-title: PLoS One
– volume: 10
  start-page: 196
  year: 2012
  end-page: 198
  ident: bib200
  article-title: Spontaneous regression of thoracic metastases while progression of brain metastases after stereotactic radiosurgery and stereotactic body radiotherapy for metastatic renal cell carcinoma: Abscopal effect prevented by the blood-brain barrier?
  publication-title: Clin Genitourin Cancer
– volume: 67
  start-page: 121
  year: 1983
  end-page: 132
  ident: bib50
  article-title: Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma
  publication-title: Cancer Treat Rep
– volume: 83
  start-page: 1306
  year: 2012
  end-page: 1310
  ident: bib210
  article-title: Maximizing tumor immunity with fractionated radiation
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 75
  start-page: 212
  year: 2009
  end-page: 219
  ident: bib83
  article-title: Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 1
  start-page: 34
  year: 2011
  end-page: 42
  ident: bib222
  article-title: Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors
  publication-title: Drug Deliv Transl Res
– volume: 75
  start-page: 559
  year: 1991
  end-page: 563
  ident: bib21
  article-title: Malignant astrocytomas: Focal tumor recurrence after focal external beam radiation therapy
  publication-title: J Neurosurg
– volume: 8
  start-page: 2243
  year: 2009
  end-page: 2254
  ident: bib180
  article-title: Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90
  publication-title: Mol Cancer Ther
– volume: 11
  start-page: 7861
  year: 2005
  end-page: 7865
  ident: bib87
  article-title: Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma
  publication-title: Clin Cancer Res
– volume: 20
  start-page: 1635
  year: 2002
  end-page: 1642
  ident: bib30
  article-title: Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy
  publication-title: J Clin Oncol
– volume: 18
  start-page: 27
  year: 2016
  end-page: 36
  ident: bib43
  article-title: Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma
  publication-title: Neuro Oncol
– volume: 12
  start-page: 801
  year: 2012
  end-page: 817
  ident: bib168
  article-title: DNA repair dysregulation from cancer driver to therapeutic target
  publication-title: Nat Rev Cancer
– volume: 21
  start-page: 4248
  year: 2015
  end-page: 4250
  ident: bib132
  article-title: CCR 20th Anniversary Commentary: bevacizumab in the treatment of glioblastoma—The progress and the limitations
  publication-title: Clin Cancer Res
– volume: 15
  start-page: 1257
  year: 2013
  end-page: 1263
  ident: bib140
  article-title: Bevacizumab as a treatment for radiation necrosis of brain metastases post stereotactic radiosurgery
  publication-title: Neuro Oncol
– volume: 27
  start-page: 1262
  year: 2009
  end-page: 1267
  ident: bib86
  article-title: Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma
  publication-title: J Clin Oncol
– volume: 62
  start-page: 125
  year: 2013
  end-page: 135
  ident: bib111
  article-title: Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
  publication-title: Cancer Immunol Immunother
– volume: 167
  start-page: 541
  year: 2007
  end-page: 550
  ident: bib34
  article-title: Effect of linear energy transfer (LET) on the complexity of alpha-particle-induced chromosome aberrations in human CD34+ cells
  publication-title: Radiat Res
– volume: 45
  start-page: 127
  year: 1999
  end-page: 135
  ident: bib120
  article-title: A phase II trial of high-dose bromodeoxyuridine with accelerated fractionation radiotherapy followed by procarbazine, lomustine, and vincristine for glioblastoma multiforme
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 434
  start-page: 913
  year: 2005
  end-page: 917
  ident: bib171
  article-title: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
  publication-title: Nature
– volume: 29A
  start-page: 940
  year: 1993
  end-page: 942
  ident: bib63
  article-title: Temozolomide: A new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours
  publication-title: Eur J Cancer
– volume: 21
  start-page: 3610
  year: 2015
  end-page: 3618
  ident: bib148
  article-title: A multicenter, phase II, randomized, noncomparative clinical trial of radiation and temozolomide with or without vandetanib in newly diagnosed glioblastoma patients
  publication-title: Clin Cancer Res
– volume: 95
  start-page: 3
  year: 2010
  end-page: 22
  ident: bib38
  article-title: Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
  publication-title: Radiother Oncol
– volume: 17
  start-page: 98
  year: 2010
  end-page: 110
  ident: bib225
  article-title: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
  publication-title: Cancer Cell
– volume: 115
  start-page: 3
  year: 2011
  end-page: 8
  ident: bib9
  article-title: An extent of resection threshold for newly diagnosed glioblastomas
  publication-title: J Neurosurg
– volume: 5
  start-page: 55
  year: 2015
  ident: bib224
  article-title: Molecular heterogeneity in glioblastoma: Potential clinical implications
  publication-title: Front Oncol
– volume: 146
  start-page: 317
  year: 1995
  end-page: 322
  ident: bib97
  article-title: Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas
  publication-title: Am J Pathol
– volume: 192
  start-page: 1027
  year: 2000
  end-page: 1034
  ident: bib190
  article-title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
  publication-title: J Exp Med
– volume: 13
  start-page: 1253
  year: 2007
  end-page: 1259
  ident: bib131
  article-title: Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
  publication-title: Clin Cancer Res
– volume: 66
  start-page: 3294
  year: 2006
  end-page: 3302
  ident: bib91
  article-title: Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma
  publication-title: Cancer Res
– volume: 60
  start-page: 985
  year: 2013
  end-page: 993
  ident: bib6
  article-title: Children’s Oncology Group’s 2013 blueprint for research: Neuroblastoma
  publication-title: Pediatr Blood Cancer
– volume: 67
  start-page: 323
  year: 2007
  end-page: 326
  ident: bib139
  article-title: Effect of bevacizumab on radiation necrosis of the brain
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 71
  start-page: 5945
  year: 2011
  end-page: 5949
  ident: bib165
  article-title: DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance
  publication-title: Cancer Res
– volume: 349
  start-page: 408
  year: 2014
  end-page: 416
  ident: bib173
  article-title: Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition
  publication-title: J Pharmacol Exp Ther
– volume: 96
  start-page: 56
  year: 2004
  end-page: 67
  ident: bib179
  article-title: Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
  publication-title: J Natl Cancer Inst
– volume: 6
  start-page: S89
  year: 2015
  end-page: S95
  ident: bib45
  article-title: Personalized medicine for gliomas
  publication-title: Surg Neurol Int
– volume: 359
  start-page: 1011
  year: 2002
  end-page: 1018
  ident: bib53
  article-title: Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
  publication-title: Lancet
– volume: 6
  start-page: 63
  year: 1998
  end-page: 70
  ident: bib116
  article-title: Effect of interstitial and/or systemic delivery of tirapazamine on the radiosensitivity of human glioblastoma multiforme in nude mice
  publication-title: Radiat Oncol Investig
– volume: 5
  start-page: 3204
  year: 2015
  end-page: 3259
  ident: bib184
  article-title: DNA damage signalling and repair inhibitors: The long-sought-after Achilles’ heel of cancer
  publication-title: Biomolecules
– ident: bib110
– volume: 36
  start-page: 566
  year: 2010
  end-page: 575
  ident: bib177
  article-title: Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers
  publication-title: Cancer Treat Rev
– volume: 20
  start-page: 81
  year: 1994
  end-page: 95
  ident: bib119
  article-title: The application of 5-bromodeoxyuridine in the management of CNS tumors
  publication-title: J Neurooncol
– volume: 41
  start-page: 1029
  year: 2012
  end-page: 1035
  ident: bib228
  article-title: Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab
  publication-title: Int J Oncol
– volume: 12
  start-page: 997
  year: 2011
  end-page: 1003
  ident: bib12
  article-title: Intraoperative MRI guidance and extent of resection in glioma surgery: A randomised, controlled trial
  publication-title: Lancet Oncol
– start-page: 5
  year: 2014
  ident: bib44
  article-title: Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells
  publication-title: Nat Commun
– volume: 6
  start-page: 553
  year: 2004
  end-page: 563
  ident: bib147
  article-title: Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
  publication-title: Cancer Cell
– volume: 57
  start-page: 145
  year: 2010
  end-page: 154
  ident: bib216
  article-title: Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo
  publication-title: IEEE Trans Biomed Eng
– volume: 363
  start-page: 411
  year: 2010
  end-page: 422
  ident: bib186
  article-title: Sipuleucel-T immunotherapy for castration-resistant prostate cancer
  publication-title: N Engl J Med
– volume: 22
  start-page: 17
  year: 2015
  end-page: 29
  ident: bib153
  article-title: DNA double-strand break repair inhibitors as cancer therapeutics
  publication-title: Chem Biol
– volume: 5
  start-page: 1725
  year: 1979
  end-page: 1731
  ident: bib25
  article-title: An analysis of dose-effect relationship in the radiotherapy of malignant gliomas
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 27
  start-page: 196
  year: 1984
  end-page: 201
  ident: bib54
  article-title: Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one, a novel broad-spectrum antitumor agent
  publication-title: J Med Chem
– volume: 350
  start-page: 2335
  year: 2004
  end-page: 2342
  ident: bib127
  article-title: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
  publication-title: N Engl J Med
– volume: 3
  start-page: 42
  year: 2011
  end-page: 44
  ident: bib89
  article-title: Mechanisms of immunomodulation in human glioblastoma
  publication-title: Immunotherapy
– volume: 33
  start-page: 4145
  year: 2015
  end-page: 4150
  ident: bib206
  article-title: International Atomic Energy Agency Randomized Phase III Study of Radiation Therapy in Elderly and/or Frail Patients With Newly Diagnosed Glioblastoma Multiforme
  publication-title: J Clin Oncol
– year: 2015
  ident: bib124
  article-title: Integrating chemoradiation and molecularly targeted therapy
  publication-title: Adv Drug Deliv Rev
– volume: 88
  start-page: 793
  year: 2014
  end-page: 800
  ident: bib208
  article-title: Phase 2 trial of hypofractionated high-dose intensity modulated radiation therapy with concurrent and adjuvant temozolomide for newly diagnosed glioblastoma
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 69
  start-page: 801
  year: 1985
  end-page: 805
  ident: bib56
  article-title: Phase I clinical trial of mitozolomide
  publication-title: Cancer Treat Rep
– volume: 82
  start-page: 383
  year: 2010
  end-page: 425
  ident: bib33
  article-title: Heavy-ion tumor therapy: Physical and radiobiological benefits
  publication-title: Rev Mod Phys
– volume: 26
  start-page: 52
  year: 2016
  end-page: 64
  ident: bib152
  article-title: Repair pathway choices and consequences at the double-strand break
  publication-title: Trends Cell Biol
– volume: 303
  start-page: 1323
  year: 1980
  end-page: 1329
  ident: bib17
  article-title: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery
  publication-title: N Engl J Med
– volume: 49
  start-page: 333
  year: 1978
  end-page: 343
  ident: bib18
  article-title: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial
  publication-title: J Neurosurg
– volume: 10
  start-page: 9
  year: 2010
  end-page: 22
  ident: bib150
  article-title: Integrins in cancer: Biological implications and therapeutic opportunities
  publication-title: Nat Rev Cancer
– volume: 5
  start-page: 85
  year: 1979
  end-page: 91
  ident: bib7
  article-title: Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
  publication-title: Int J Radiat Oncol Biol Phys
– ident: bib183
– volume: 15
  start-page: 5379
  year: 2009
  end-page: 5388
  ident: bib212
  article-title: Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
  publication-title: Clin Cancer Res
– volume: 52
  start-page: 997
  year: 1983
  end-page: 1007
  ident: bib27
  article-title: Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study
  publication-title: Cancer
– volume: 17
  start-page: 57
  year: 2004
  end-page: 64
  ident: bib92
  article-title: T lymphocyte subsets and immunoglobulins in intracranial tumor patients before and after treatment, and based on histological type of tumors
  publication-title: Int J Immunopathol Pharmacol
– volume: 47
  start-page: 5846
  year: 1987
  end-page: 5852
  ident: bib58
  article-title: Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine
  publication-title: Cancer Res
– volume: 123
  start-page: 459
  year: 2015
  end-page: 464
  ident: bib104
  article-title: Combining immunotherapy with radiation for the treatment of glioblastoma
  publication-title: J Neurooncol
– volume: 68
  start-page: 873
  year: 2007
  end-page: 882
  ident: bib81
  article-title: In vitro responsiveness of glioma cell lines to multimodality treatment with radiotherapy, temozolomide, and epidermal growth factor receptor inhibition with cetuximab
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 51
  start-page: 279
  year: 2005
  end-page: 285
  ident: bib96
  article-title: Impaired capacity for upregulation of MHC class II in tumor-associated microglia
  publication-title: Glia
– volume: 225
  start-page: 195
  year: 2010
  end-page: 199
  ident: bib101
  article-title: Prognostic significance and mechanism of Treg infiltration in human brain tumors
  publication-title: J Neuroimmunol
– volume: 370
  start-page: 699
  year: 2014
  end-page: 708
  ident: bib136
  article-title: A randomized trial of bevacizumab for newly diagnosed glioblastoma
  publication-title: N Engl J Med
– volume: 40
  start-page: 179
  year: 2010
  end-page: 204
  ident: bib156
  article-title: The DNA damage response: Making it safe to play with knives
  publication-title: Molecular Cell
– volume: 74
  start-page: 1323
  year: 2009
  end-page: 1331
  ident: bib162
  article-title: Clinical radiation sensitivity with DNA repair disorders: An overview
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 20
  start-page: 1375
  year: 2002
  end-page: 1382
  ident: bib70
  article-title: Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide
  publication-title: J Clin Oncol
– volume: 15
  start-page: 1100
  year: 2014
  end-page: 1108
  ident: bib151
  article-title: Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071–22072 study): A multicentre, randomised, open-label, phase 3 trial
  publication-title: Lancet Oncol
– volume: 5
  start-page: 894
  year: 2007
  end-page: 902
  ident: bib114
  article-title: Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme
  publication-title: Clin Adv Hematol Oncol
– volume: 8
  start-page: 92
  year: 1997
  end-page: 97
  ident: bib78
  article-title: In vitro evaluation of temozolomide combined with X-irradiation
  publication-title: Anticancer Drugs
– volume: 10
  start-page: 1871
  year: 2004
  end-page: 1874
  ident: bib76
  article-title: Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
  publication-title: Clin Cancer Res
– volume: 10
  start-page: 293
  year: 2010
  end-page: 301
  ident: bib170
  article-title: PARP inhibition: PARP1 and beyond
  publication-title: Nat Rev Cancer
– volume: 33
  year: 2015
  ident: bib113
  article-title: Newly diagnosed glioblastoma patients treated with an autologous heat shock protein peptide vaccine: PD-L1 expression and response to therapy
  publication-title: J Clin Oncol
– volume: 12
  start-page: 4730
  year: 2006
  end-page: 4737
  ident: bib201
  article-title: The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas
  publication-title: Clin Cancer Res
– volume: 94
  start-page: 63
  year: 2009
  end-page: 68
  ident: bib141
  article-title: Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis
  publication-title: J Neurooncol
– volume: 88
  start-page: 793
  issue: 4
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib208
  article-title: Phase 2 trial of hypofractionated high-dose intensity modulated radiation therapy with concurrent and adjuvant temozolomide for newly diagnosed glioblastoma
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2013.12.011
– volume: 16
  start-page: 54
  issue: 11
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib103
  article-title: An update on the role of immunotherapy and vaccine strategies for primary brain tumors
  publication-title: Curr Treat Options Oncol
  doi: 10.1007/s11864-015-0371-3
– volume: 8
  start-page: 1616
  issue: 8
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib182
  article-title: Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells
  publication-title: Mol Oncol
  doi: 10.1016/j.molonc.2014.06.008
– volume: 359
  start-page: 1011
  issue: 9311
  year: 2002
  ident: 10.1016/j.semradonc.2016.06.003_bib53
  article-title: Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
  publication-title: Lancet
  doi: 10.1016/S0140-6736(02)08091-1
– volume: 21
  start-page: 4248
  issue: 19
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib132
  article-title: CCR 20th Anniversary Commentary: bevacizumab in the treatment of glioblastoma—The progress and the limitations
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-15-1381
– volume: 434
  start-page: 917
  issue: 7035
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib172
  article-title: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
  publication-title: Nature
  doi: 10.1038/nature03445
– volume: 449
  start-page: 483
  issue: 7161
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib158
  article-title: Rag mutations reveal robust alternative end joining
  publication-title: Nature
  doi: 10.1038/nature06168
– volume: 2
  start-page: 831
  issue: 9
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib191
  article-title: Combining radiation and immunotherapy: A new systemic therapy for solid tumors? Cancer
  publication-title: Immunol Res
– volume: 12
  start-page: 1239
  issue: 7
  year: 1986
  ident: 10.1016/j.semradonc.2016.06.003_bib115
  article-title: SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(86)90267-1
– volume: 40
  start-page: 179
  issue: 2
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib156
  article-title: The DNA damage response: Making it safe to play with knives
  publication-title: Molecular Cell
  doi: 10.1016/j.molcel.2010.09.019
– volume: 33
  start-page: 4145
  issue: 35
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib206
  article-title: International Atomic Energy Agency Randomized Phase III Study of Radiation Therapy in Elderly and/or Frail Patients With Newly Diagnosed Glioblastoma Multiforme
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2015.62.6606
– volume: 26
  start-page: 52
  issue: 1
  year: 2016
  ident: 10.1016/j.semradonc.2016.06.003_bib152
  article-title: Repair pathway choices and consequences at the double-strand break
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2015.07.009
– volume: 38
  start-page: 242
  issue: 3
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib3
  article-title: Outcomes after multidisciplinary treatment of inflammatory breast cancer in the era of neoadjuvant HER2-directed therapy
  publication-title: Am J Clin Oncol
  doi: 10.1097/COC.0b013e3182937921
– volume: 75
  start-page: 729
  issue: 4
  year: 1993
  ident: 10.1016/j.semradonc.2016.06.003_bib155
  article-title: Loss of a yeast telomere: Arrest, recovery, and chromosome loss
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90493-A
– volume: 10
  start-page: 1871
  issue: 6
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib76
  article-title: Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-03-0384
– volume: 11
  start-page: 799
  issue: 6
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib214
  article-title: Convection-enhanced delivery of 131I-chTNT-1/B mAB for treatment of high-grade adult gliomas
  publication-title: Expert Opin Biol Ther
  doi: 10.1517/14712598.2011.579097
– volume: 23
  start-page: 792
  issue: 4
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib126
  article-title: Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2005.05.098
– volume: 10
  start-page: 1949
  issue: 10
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib178
  article-title: Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-11-0278
– volume: 204
  start-page: 1717
  issue: 7
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib160
  article-title: Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination
  publication-title: J Exp Med
  doi: 10.1084/jem.20070255
– volume: 19
  start-page: 879
  issue: 6
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib137
  article-title: Upregulation of VEGF and FGF2 in normal rat brain after experimental intraoperative radiation therapy
  publication-title: J Korean Med Sci
  doi: 10.3346/jkms.2004.19.6.879
– volume: 7
  start-page: 41
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib32
  article-title: Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT): Early treatment results and study concepts
  publication-title: Radiat Oncol
  doi: 10.1186/1748-717X-7-41
– volume: 65
  start-page: 287
  issue: 2
  year: 1992
  ident: 10.1016/j.semradonc.2016.06.003_bib59
  article-title: Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  publication-title: Br J Cancer
  doi: 10.1038/bjc.1992.57
– volume: 82
  start-page: 383
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib33
  article-title: Heavy-ion tumor therapy: Physical and radiobiological benefits
  publication-title: Rev Mod Phys
  doi: 10.1103/RevModPhys.82.383
– volume: 47
  start-page: 5846
  issue: 22
  year: 1987
  ident: 10.1016/j.semradonc.2016.06.003_bib58
  article-title: Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine
  publication-title: Cancer Res
– volume: 449
  start-page: 478
  issue: 7161
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib161
  article-title: IgH class switching and translocations use a robust non-classical end-joining pathway
  publication-title: Nature
  doi: 10.1038/nature06020
– volume: 17
  start-page: 57
  issue: 1
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib92
  article-title: T lymphocyte subsets and immunoglobulins in intracranial tumor patients before and after treatment, and based on histological type of tumors
  publication-title: Int J Immunopathol Pharmacol
  doi: 10.1177/039463200401700108
– volume: 17
  start-page: 475
  issue: 6
  year: 1978
  ident: 10.1016/j.semradonc.2016.06.003_bib16
  article-title: Postoperative irradiation of glioblastomas. Results in a randomized series
  publication-title: Acta Radiol Oncol Radiat Phys Biol
  doi: 10.3109/02841867809128178
– volume: 34
  start-page: 793
  issue: 4
  year: 1996
  ident: 10.1016/j.semradonc.2016.06.003_bib49
  article-title: A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(95)02025-X
– volume: 434
  start-page: 913
  issue: 7035
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib171
  article-title: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
  publication-title: Nature
  doi: 10.1038/nature03443
– volume: 12
  start-page: 801
  issue: 12
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib168
  article-title: DNA repair dysregulation from cancer driver to therapeutic target
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3399
– volume: 4
  start-page: 137ra74
  issue: 137
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib209
  article-title: Phase 1 study of stereotactic body radiotherapy and interleukin-2—Tumor and immunological responses
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3003649
– volume: 67
  start-page: 121
  issue: 2
  year: 1983
  ident: 10.1016/j.semradonc.2016.06.003_bib50
  article-title: Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma
  publication-title: Cancer Treat Rep
– volume: 96
  start-page: 56
  issue: 1
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib179
  article-title: Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/djh005
– volume: 52
  start-page: 997
  issue: 6
  year: 1983
  ident: 10.1016/j.semradonc.2016.06.003_bib27
  article-title: Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study
  publication-title: Cancer
  doi: 10.1002/1097-0142(19830915)52:6<997::AID-CNCR2820520612>3.0.CO;2-2
– volume: 8
  start-page: 92
  issue: 1
  year: 1997
  ident: 10.1016/j.semradonc.2016.06.003_bib78
  article-title: In vitro evaluation of temozolomide combined with X-irradiation
  publication-title: Anticancer Drugs
  doi: 10.1097/00001813-199701000-00013
– volume: 9
  start-page: e101764
  issue: 7
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib203
  article-title: Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0101764
– volume: 56
  start-page: 1243
  issue: 6
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib218
  article-title: Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: Initial experience in 51 patients
  publication-title: Neurosurgery
  doi: 10.1227/01.NEU.0000159649.71890.30
– volume: 370
  start-page: 709
  issue: 8
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib135
  article-title: Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1308345
– volume: 20
  start-page: 81
  issue: 1
  year: 1994
  ident: 10.1016/j.semradonc.2016.06.003_bib119
  article-title: The application of 5-bromodeoxyuridine in the management of CNS tumors
  publication-title: J Neurooncol
  doi: 10.1007/BF01057964
– volume: 10
  start-page: 293
  issue: 4
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib170
  article-title: PARP inhibition: PARP1 and beyond
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2812
– volume: 57
  start-page: 145
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib216
  article-title: Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo
  publication-title: IEEE Trans Biomed Eng
  doi: 10.1109/TBME.2009.2034533
– year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib124
  article-title: Integrating chemoradiation and molecularly targeted therapy
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2015.11.007
– volume: 6
  start-page: e16195
  issue: 1
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib102
  article-title: Hypoxia potentiates glioma-mediated immunosuppression
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0016195
– volume: 12
  start-page: 997
  issue: 11
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib12
  article-title: Intraoperative MRI guidance and extent of resection in glioma surgery: A randomised, controlled trial
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(11)70196-6
– volume: 283
  start-page: 1
  issue: 1
  year: 2008
  ident: 10.1016/j.semradonc.2016.06.003_bib157
  article-title: The mechanism of human nonhomologous DNA end joining
  publication-title: J Biol Chem
  doi: 10.1074/jbc.R700039200
– volume: 5
  start-page: 239
  issue: 3
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib215
  article-title: Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy
  publication-title: Technol Cancer Res Treat
  doi: 10.1177/153303460600500307
– volume: 47
  start-page: 779
  issue: 3
  year: 2000
  ident: 10.1016/j.semradonc.2016.06.003_bib79
  article-title: Survival of human glioma cells treated with various combination of temozolomide and X-rays
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/S0360-3016(99)00539-8
– volume: 8
  start-page: 261
  issue: 3
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib99
  article-title: The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
  publication-title: Neuro Oncol
  doi: 10.1215/15228517-2006-008
– volume: 18
  start-page: 27
  issue: 1
  year: 2016
  ident: 10.1016/j.semradonc.2016.06.003_bib43
  article-title: Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nov164
– volume: 36
  start-page: 566
  issue: 7
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib177
  article-title: Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers
  publication-title: Cancer Treat Rev
  doi: 10.1016/j.ctrv.2010.03.003
– volume: 11
  start-page: 728
  issue: 2 Pt 1
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib193
  article-title: Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.728.11.2
– volume: 70
  start-page: 4829
  issue: 12
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib100
  article-title: Immune infiltration of spontaneous mouse astrocytomas is dominated by immunosuppressive cells from early stages of tumor development
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-09-3074
– volume: 71
  start-page: 5945
  issue: 18
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib165
  article-title: DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-11-1245
– volume: 11
  start-page: 8304
  issue: 23
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib95
  article-title: Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-04-2588
– volume: 105
  start-page: 423
  issue: 2
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib138
  article-title: The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: Pathological consideration of their potential roles
  publication-title: J Neurooncol
  doi: 10.1007/s11060-011-0610-9
– volume: 12
  start-page: 104
  issue: 2
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib72
  article-title: Balancing repair and tolerance of DNA damage caused by alkylating agents
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3185
– volume: 33
  issue: suppl
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib113
  article-title: Newly diagnosed glioblastoma patients treated with an autologous heat shock protein peptide vaccine: PD-L1 expression and response to therapy
  publication-title: J Clin Oncol
– volume: 10
  start-page: 9
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib150
  article-title: Integrins in cancer: Biological implications and therapeutic opportunities
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2748
– volume: 512
  start-page: 324
  issue: 7514
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib229
  article-title: A vaccine targeting mutant IDH1 induces antitumour immunity
  publication-title: Nature
  doi: 10.1038/nature13387
– volume: 70
  start-page: 1781
  issue: 5
  year: 1998
  ident: 10.1016/j.semradonc.2016.06.003_bib41
  article-title: CNS drug design based on principles of blood-brain barrier transport
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.1998.70051781.x
– volume: 33
  start-page: 4240
  issue: 36
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib5
  article-title: Role of chemoradiotherapy in elderly patients with limited-stage small-cell lung cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2015.62.4270
– volume: 11
  start-page: 7861
  issue: 21
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib87
  article-title: Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-05-0060
– volume: 12
  start-page: 1061
  issue: 10
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib226
  article-title: Safety and efficacy of erlotinib in first-relapse glioblastoma: A phase II open-label study
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/noq072
– volume: 11
  start-page: 1795
  issue: 10
  year: 1985
  ident: 10.1016/j.semradonc.2016.06.003_bib35
  article-title: A phase I-II trial of heavy charged particle irradiation of malignant glioma of the brain: A Northern California Oncology Group Study
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(85)90034-3
– volume: 5
  start-page: 894
  issue: 11
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib114
  article-title: Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme
  publication-title: Clin Adv Hematol Oncol
– volume: 14
  start-page: 111
  issue: 1
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib88
  article-title: Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-14-0113
– volume: 74
  start-page: 1323
  issue: 5
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib162
  article-title: Clinical radiation sensitivity with DNA repair disorders: An overview
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2009.02.057
– volume: 22
  start-page: 501
  issue: 4
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib74
  article-title: ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.04.023
– volume: 31
  start-page: 4085
  issue: 32
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib84
  article-title: Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2013.49.6968
– volume: 9
  start-page: 1
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib46
  article-title: Glioblastoma: From molecular pathology to targeted treatment
  publication-title: Annu Rev Pathol
  doi: 10.1146/annurev-pathol-011110-130324
– volume: 60
  start-page: 853
  issue: 3
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib29
  article-title: Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: Report of Radiation Therapy Oncology Group 93-05 protocol
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2004.04.011
– volume: 6
  start-page: 279
  year: 1988
  ident: 10.1016/j.semradonc.2016.06.003_bib28
  article-title: Combined modality approach to treatment of malignant gliomas—Re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up: A joint study of the Radiation Therapy Oncology Group and the Eastern Cooperative Oncology Group
  publication-title: NCI Monogr
– volume: 67
  start-page: 3663
  issue: 21
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib85
  article-title: Targeting O(6)-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-010-0491-7
– volume: 9
  start-page: 125
  issue: 2
  year: 1990
  ident: 10.1016/j.semradonc.2016.06.003_bib98
  article-title: In vitro prostaglandin E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes
  publication-title: J Neurooncol
  doi: 10.1007/BF02427832
– volume: 11
  start-page: 1462
  issue: 4
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib106
  article-title: Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-04-1737
– volume: 203
  start-page: 1259
  issue: 5
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib192
  article-title: Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
  publication-title: J Exp Med
  doi: 10.1084/jem.20052494
– volume: 58
  start-page: 4363
  issue: 19
  year: 1998
  ident: 10.1016/j.semradonc.2016.06.003_bib69
  article-title: Phase I trial of temozolomide using an extended continuous oral schedule
  publication-title: Cancer Res
– volume: 16
  start-page: 1405
  issue: 6
  year: 1989
  ident: 10.1016/j.semradonc.2016.06.003_bib20
  article-title: Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(89)90941-3
– volume: 49
  start-page: 333
  issue: 3
  year: 1978
  ident: 10.1016/j.semradonc.2016.06.003_bib18
  article-title: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial
  publication-title: J Neurosurg
  doi: 10.3171/jns.1978.49.3.0333
– volume: 20
  start-page: 151
  issue: Suppl 1
  year: 1991
  ident: 10.1016/j.semradonc.2016.06.003_bib117
  article-title: SR 4233: A tumor specific radiosensitizer active in fractionated radiation regimes
  publication-title: Radiother Oncol
  doi: 10.1016/0167-8140(91)90203-S
– volume: 6
  start-page: 2585
  issue: 7
  year: 2000
  ident: 10.1016/j.semradonc.2016.06.003_bib73
  article-title: Temozolomide and treatment of malignant glioma
  publication-title: Clin Cancer Res
– volume: 81
  start-page: 1022
  issue: 6
  year: 1999
  ident: 10.1016/j.semradonc.2016.06.003_bib62
  article-title: Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6690802
– volume: 64
  start-page: 892
  issue: 3
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib22
  article-title: Intensity-modulated radiotherapy in high-grade gliomas: Clinical and dosimetric results
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2005.05.067
– volume: 17
  start-page: 2604
  issue: 8
  year: 1999
  ident: 10.1016/j.semradonc.2016.06.003_bib60
  article-title: Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.1999.17.8.2604
– start-page: 143
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib169
  article-title: Targeting DNA double-strand break signalling and repair: Recent advances in cancer therapy
  publication-title: Swiss Med Wkly
– volume: 5
  start-page: 404
  issue: 6
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib198
  article-title: A systemic complete response of metastatic melanoma to local radiation and immunotherapy
  publication-title: Transl Oncol
  doi: 10.1593/tlo.12280
– volume: 7
  start-page: 813
  issue: 10
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib1
  article-title: Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): Long-term results from a prospective, multicentre trial
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(06)70867-1
– volume: 83
  start-page: 1306
  issue: 4
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib210
  article-title: Maximizing tumor immunity with fractionated radiation
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2011.09.049
– volume: 1
  start-page: 94
  issue: 3
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib217
  article-title: Neurocognitive functioning and quality of life in patients with recurrent malignant gliomas treated on a phase Ib trial evaluating topotecan by convection-enhanced delivery
  publication-title: Neurooncol Pract
– volume: 72
  start-page: 1188
  issue: 4
  year: 2008
  ident: 10.1016/j.semradonc.2016.06.003_bib181
  article-title: Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: Mechanisms and therapeutic potential
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2008.07.031
– start-page: 5
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib44
  article-title: Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells
  publication-title: Nat Commun
– volume: 18
  start-page: 1254
  issue: 6
  year: 2000
  ident: 10.1016/j.semradonc.2016.06.003_bib118
  article-title: Single-arm, open-label phase II study of intravenously administered tirapazamine and radiation therapy for glioblastoma multiforme
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2000.18.6.1254
– volume: 17
  start-page: vii15
  issue: suppl 7
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib105
  article-title: Vaccination strategies for neuro-oncology
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nov159
– volume: 28
  start-page: e577
  issue: 29
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib125
  article-title: Radiosensitizing drugs: Lessons to be learned from the oxaliplatin story
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2010.30.0921
– volume: 22
  start-page: 17
  issue: 1
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib153
  article-title: DNA double-strand break repair inhibitors as cancer therapeutics
  publication-title: Chem Biol
  doi: 10.1016/j.chembiol.2014.11.013
– volume: 5
  start-page: 55
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib224
  article-title: Molecular heterogeneity in glioblastoma: Potential clinical implications
  publication-title: Front Oncol
  doi: 10.3389/fonc.2015.00055
– volume: 38
  start-page: 257
  issue: 2
  year: 1997
  ident: 10.1016/j.semradonc.2016.06.003_bib36
  article-title: Neon heavy charged particle radiotherapy of glioblastoma of the brain
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/S0360-3016(97)00039-4
– volume: 27
  start-page: 1262
  issue: 8
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib86
  article-title: Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2008.18.8417
– volume: 20
  start-page: 1635
  issue: 6
  year: 2002
  ident: 10.1016/j.semradonc.2016.06.003_bib30
  article-title: Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.20.6.1635
– volume: 7
  start-page: 392
  issue: 5
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib13
  article-title: Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(06)70665-9
– volume: 10
  start-page: e0132266
  issue: 7
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib221
  article-title: Convection-enhanced delivery of carboplatin PLGA nanoparticles for the treatment of glioblastoma
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0132266
– volume: 13
  start-page: 916
  issue: 9
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib204
  article-title: Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(12)70265-6
– volume: 40
  start-page: 484
  issue: 6
  year: 1997
  ident: 10.1016/j.semradonc.2016.06.003_bib65
  article-title: Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s002800050691
– volume: 363
  start-page: 411
  issue: 5
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib186
  article-title: Sipuleucel-T immunotherapy for castration-resistant prostate cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1001294
– volume: 17
  start-page: 98
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib225
  article-title: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2009.12.020
– volume: 8
  start-page: 47
  issue: 1
  year: 2002
  ident: 10.1016/j.semradonc.2016.06.003_bib145
  article-title: Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance
  publication-title: Cancer J
  doi: 10.1097/00130404-200201000-00009
– volume: 6
  start-page: 553
  issue: 6
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib147
  article-title: Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
  publication-title: Cancer Cell
– volume: 350
  start-page: 2335
  issue: 23
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib127
  article-title: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa032691
– volume: 13
  start-page: 433
  issue: 2
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib174
  article-title: Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-13-0803
– volume: 80
  start-page: 1074
  issue: 6
  year: 1994
  ident: 10.1016/j.semradonc.2016.06.003_bib194
  article-title: The effect of irradiation on expression of HLA class I antigens in human brain tumors in culture
  publication-title: J Neurosurg
  doi: 10.3171/jns.1994.80.6.1074
– volume: 366
  start-page: 925
  issue: 10
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib199
  article-title: Immunologic correlates of the abscopal effect in a patient with melanoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1112824
– volume: 7
  start-page: 369
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib129
  article-title: Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma (abstract)
  publication-title: Neuro Oncol
– volume: 33
  start-page: 9045
  issue: 31
  year: 1994
  ident: 10.1016/j.semradonc.2016.06.003_bib71
  article-title: NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
  publication-title: Biochemistry
  doi: 10.1021/bi00197a003
– volume: 46
  start-page: 1
  issue: 1
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib4
  article-title: Shifting paradigm in the management of anal canal carcinoma
  publication-title: J Gastrointest Cancer
  doi: 10.1007/s12029-014-9673-0
– volume: 32A
  start-page: 2236
  issue: 13
  year: 1996
  ident: 10.1016/j.semradonc.2016.06.003_bib64
  article-title: The Charing Cross Hospital experience with temozolomide in patients with gliomas
  publication-title: Eur J Cancer
  doi: 10.1016/S0959-8049(96)00258-4
– volume: 75
  start-page: 4416
  issue: 20
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib166
  article-title: Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-14-3790
– volume: 18
  start-page: 321
  issue: 2
  year: 1990
  ident: 10.1016/j.semradonc.2016.06.003_bib47
  article-title: Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(90)90096-3
– start-page: 1
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib10
  article-title: The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection?
  publication-title: J Neurosurg
– volume: 90
  start-page: 823
  issue: 11
  year: 1928
  ident: 10.1016/j.semradonc.2016.06.003_bib15
  article-title: Removal of right cerebral hemisphere for certain tumors with hemiplegia: Preliminary report
  publication-title: J Am Med Assoc
  doi: 10.1001/jama.1928.02690380007003
– volume: 110
  start-page: 11751
  issue: 29
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib223
  article-title: Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1304504110
– volume: 25
  start-page: 4722
  issue: 30
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib130
  article-title: Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2007.12.2440
– volume: 12
  start-page: 871
  issue: 8
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib220
  article-title: Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nop054
– volume: 123
  start-page: 459
  issue: 3
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib104
  article-title: Combining immunotherapy with radiation for the treatment of glioblastoma
  publication-title: J Neurooncol
  doi: 10.1007/s11060-015-1762-9
– volume: 20
  start-page: 1375
  issue: 5
  year: 2002
  ident: 10.1016/j.semradonc.2016.06.003_bib70
  article-title: Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.20.5.1375
– volume: 75
  start-page: 559
  issue: 4
  year: 1991
  ident: 10.1016/j.semradonc.2016.06.003_bib21
  article-title: Malignant astrocytomas: Focal tumor recurrence after focal external beam radiation therapy
  publication-title: J Neurosurg
  doi: 10.3171/jns.1991.75.4.0559
– volume: 19
  start-page: 843
  issue: 3
  year: 2001
  ident: 10.1016/j.semradonc.2016.06.003_bib128
  article-title: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2001.19.3.843
– volume: 5
  start-page: 3204
  issue: 4
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib184
  article-title: DNA damage signalling and repair inhibitors: The long-sought-after Achilles’ heel of cancer
  publication-title: Biomolecules
  doi: 10.3390/biom5043204
– volume: 19
  start-page: 509
  issue: 2
  year: 2001
  ident: 10.1016/j.semradonc.2016.06.003_bib52
  article-title: Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: A Medical Research Council trial
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2001.19.2.509
– volume: 2013
  start-page: 658126
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib211
  article-title: Immune modulation and stereotactic radiation: Improving local and abscopal responses
  publication-title: Biomed Res Int
  doi: 10.1155/2013/658126
– volume: 95
  start-page: 190
  issue: 2
  year: 2001
  ident: 10.1016/j.semradonc.2016.06.003_bib8
  article-title: A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival
  publication-title: J Neurosurg
  doi: 10.3171/jns.2001.95.2.0190
– volume: 21
  start-page: 3610
  issue: 16
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib148
  article-title: A multicenter, phase II, randomized, noncomparative clinical trial of radiation and temozolomide with or without vandetanib in newly diagnosed glioblastoma patients
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-14-3220
– volume: 62
  start-page: 450
  issue: 6
  year: 1987
  ident: 10.1016/j.semradonc.2016.06.003_bib14
  article-title: Stereotactic histologic correlations of computed tomography- and magnetic resonance imaging-defined abnormalities in patients with glial neoplasms
  publication-title: Mayo Clin Proc
  doi: 10.1016/S0025-6196(12)65470-6
– volume: 51
  start-page: 279
  issue: 4
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib96
  article-title: Impaired capacity for upregulation of MHC class II in tumor-associated microglia
  publication-title: Glia
  doi: 10.1002/glia.20201
– volume: 66
  start-page: 3294
  issue: 6
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib91
  article-title: Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-3773
– ident: 10.1016/j.semradonc.2016.06.003_bib68
– volume: 29A
  start-page: 940
  issue: 7
  year: 1993
  ident: 10.1016/j.semradonc.2016.06.003_bib63
  article-title: Temozolomide: A new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours
  publication-title: Eur J Cancer
  doi: 10.1016/S0959-8049(05)80198-4
– volume: 60
  start-page: 985
  issue: 6
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib6
  article-title: Children’s Oncology Group’s 2013 blueprint for research: Neuroblastoma
  publication-title: Pediatr Blood Cancer
  doi: 10.1002/pbc.24433
– volume: 115
  start-page: 3
  issue: 1
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib9
  article-title: An extent of resection threshold for newly diagnosed glioblastomas
  publication-title: J Neurosurg
  doi: 10.3171/2011.2.JNS10998
– volume: 27
  start-page: 740
  issue: 5
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib134
  article-title: Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2008.16.3055
– volume: 3
  start-page: 1093
  issue: 7
  year: 1997
  ident: 10.1016/j.semradonc.2016.06.003_bib61
  article-title: Phase I trial of temozolomide (NSC 362856) in patients with advanced cancer
  publication-title: Clin Cancer Res
– volume: 69
  start-page: 4252
  issue: 10
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib164
  article-title: EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-4853
– volume: 95
  start-page: 3
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib38
  article-title: Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
  publication-title: Radiother Oncol
  doi: 10.1016/j.radonc.2010.01.015
– volume: 12
  start-page: 4738
  issue: 15
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib80
  article-title: Temozolomide-mediated radiation enhancement in glioblastoma: A report on underlying mechanisms
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-06-0596
– volume: 24
  start-page: 3117
  issue: 12
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib11
  article-title: Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapy
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdt388
– volume: 22
  start-page: 465
  issue: 3
  year: 1988
  ident: 10.1016/j.semradonc.2016.06.003_bib26
  article-title: Survival after stereotactic biopsy of malignant gliomas
  publication-title: Neurosurgery
  doi: 10.1227/00006123-198803000-00003
– volume: 5
  start-page: 85
  issue: 1
  year: 1979
  ident: 10.1016/j.semradonc.2016.06.003_bib7
  article-title: Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(79)90044-0
– volume: 21
  start-page: 31
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib94
  article-title: Glioblastoma-derived mechanisms of systemic immunosuppression
  publication-title: Neurosurg Clin N Am
  doi: 10.1016/j.nec.2009.08.005
– volume: 21
  start-page: 633
  issue: 4
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib207
  article-title: Hypofractionated intensity modulated radiotherapy with temozolomide in newly diagnosed glioblastoma multiforme
  publication-title: J Clin Neurosci
  doi: 10.1016/j.jocn.2013.09.005
– volume: 20
  start-page: 3730
  issue: 14
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib176
  article-title: Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus-resistant glioblastoma multiforme xenografts
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-13-3446
– volume: 57
  start-page: 2933
  issue: 14
  year: 1997
  ident: 10.1016/j.semradonc.2016.06.003_bib77
  article-title: Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft
  publication-title: Cancer Res
– volume: 90
  start-page: 5613
  issue: 12
  year: 1993
  ident: 10.1016/j.semradonc.2016.06.003_bib154
  article-title: Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.90.12.5613
– volume: 9
  issue: 5
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib213
  article-title: Peptide carrier-mediated non-covalent delivery of unmodified cisplatin, methotrexate and other agents via intravenous route to the brain
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0097655
– volume: 27
  start-page: 196
  issue: 2
  year: 1984
  ident: 10.1016/j.semradonc.2016.06.003_bib54
  article-title: Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one, a novel broad-spectrum antitumor agent
  publication-title: J Med Chem
  doi: 10.1021/jm00368a016
– volume: 68
  start-page: 873
  issue: 3
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib81
  article-title: In vitro responsiveness of glioma cell lines to multimodality treatment with radiotherapy, temozolomide, and epidermal growth factor receptor inhibition with cetuximab
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2007.03.002
– volume: 26
  start-page: 1182
  issue: 12
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib2
  article-title: Combined-modality therapy for early-stage Hodgkin lymphoma: Maintaining high cure rates while minimizing risks
  publication-title: Oncology (Williston Park)
– volume: 167
  start-page: 541
  issue: 5
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib34
  article-title: Effect of linear energy transfer (LET) on the complexity of alpha-particle-induced chromosome aberrations in human CD34+ cells
  publication-title: Radiat Res
  doi: 10.1667/RR0813.1
– volume: 341
  start-page: 395
  issue: 6144
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib163
  article-title: Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress
  publication-title: Science
  doi: 10.1126/science.1236188
– volume: 41
  start-page: 1029
  issue: 3
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib228
  article-title: Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2012.1539
– volume: 6
  start-page: 1079
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib143
  article-title: Combining molecular targeted agents with radiation therapy for malignant gliomas
  publication-title: Onco Targets Ther
– volume: 20
  start-page: 1309
  issue: 6
  year: 1991
  ident: 10.1016/j.semradonc.2016.06.003_bib23
  article-title: Three-dimensional treatment planning of astrocytomas: A dosimetric study of cerebral irradiation
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(91)90243-W
– volume: 12
  start-page: 4730
  issue: 15
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib201
  article-title: The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-06-0593
– volume: 67
  start-page: 323
  issue: 2
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib139
  article-title: Effect of bevacizumab on radiation necrosis of the brain
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2006.10.010
– volume: 363
  start-page: 711
  issue: 8
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib185
  article-title: Improved survival with ipilimumab in patients with metastatic melanoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1003466
– volume: 86
  start-page: 343
  issue: 2
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib202
  article-title: Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2012.12.025
– volume: 28
  start-page: 4722
  issue: 31
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib107
  article-title: Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2010.28.6963
– volume: 15
  start-page: 5379
  issue: 17
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib212
  article-title: Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-09-0265
– volume: 349
  start-page: 408
  issue: 3
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib173
  article-title: Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.113.210146
– volume: 146
  start-page: 317
  issue: 2
  year: 1995
  ident: 10.1016/j.semradonc.2016.06.003_bib97
  article-title: Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas
  publication-title: Am J Pathol
– volume: 519
  start-page: 366
  issue: 7543
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib112
  article-title: Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients
  publication-title: Nature
  doi: 10.1038/nature14320
– volume: 13
  start-page: 132
  issue: 1
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib219
  article-title: Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/noq142
– volume: 110
  start-page: 2655
  issue: 11
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib146
  article-title: Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2014.209
– volume: 18
  start-page: 378
  issue: 3
  year: 2008
  ident: 10.1016/j.semradonc.2016.06.003_bib149
  article-title: Expression of integrin αvβ3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature
  publication-title: Brain Pathol
  doi: 10.1111/j.1750-3639.2008.00137.x
– volume: 1
  start-page: 365
  issue: 6
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib197
  article-title: An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-13-0115
– volume: 71
  start-page: 1
  issue: 1
  year: 1989
  ident: 10.1016/j.semradonc.2016.06.003_bib51
  article-title: Randomized trial of three chemotherapy regimens and two radiotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001
  publication-title: J Neurosurg
  doi: 10.3171/jns.1989.71.1.0001
– volume: 75
  start-page: 212
  issue: 1
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib83
  article-title: Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2009.04.026
– volume: 69
  start-page: 831
  issue: 3
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib122
  article-title: Results of the phase I dose-escalating study of motexafin gadolinium with standard radiotherapy in patients with glioblastoma multiforme
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2007.04.017
– volume: 79
  start-page: 1487
  issue: 5
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib142
  article-title: Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2009.12.061
– volume: 5
  start-page: 1725
  issue: 10
  year: 1979
  ident: 10.1016/j.semradonc.2016.06.003_bib25
  article-title: An analysis of dose-effect relationship in the radiotherapy of malignant gliomas
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/0360-3016(79)90553-4
– volume: 62
  start-page: 125
  issue: 1
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib111
  article-title: Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
  publication-title: Cancer Immunol Immunother
  doi: 10.1007/s00262-012-1319-0
– volume: 83
  start-page: 588
  issue: 5
  year: 2000
  ident: 10.1016/j.semradonc.2016.06.003_bib66
  article-title: A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse
  publication-title: Br J Cancer
  doi: 10.1054/bjoc.2000.1316
– volume: 6
  start-page: 39
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib75
  article-title: MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
  publication-title: Nat Rev Neurol
  doi: 10.1038/nrneurol.2009.197
– volume: 40
  start-page: 10
  issue: 1
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib196
  article-title: The immune mechanisms of abscopal effect in radiation therapy
  publication-title: Curr Probl Cancer
  doi: 10.1016/j.currproblcancer.2015.10.003
– volume: 100
  start-page: 216
  issue: 1-2
  year: 1999
  ident: 10.1016/j.semradonc.2016.06.003_bib90
  article-title: Immune defects observed in patients with primary malignant brain tumors
  publication-title: J Neuroimmunol
  doi: 10.1016/S0165-5728(99)00203-9
– volume: 16
  start-page: 1441
  issue: 11
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib93
  article-title: Immunotherapy advances for glioblastoma
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nou212
– volume: 58
  start-page: 1147
  issue: 4
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib121
  article-title: Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: Final report of RTOG 9404
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2003.08.024
– volume: 9
  start-page: 130
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib24
  article-title: Patterns of failure for glioblastoma multiforme following limited-margin radiation and concurrent temozolomide
  publication-title: Radiat Oncol
  doi: 10.1186/1748-717X-9-130
– volume: 69
  start-page: 1246
  issue: 4
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib82
  article-title: Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2007.07.2366
– volume: 1
  start-page: 34
  issue: 1
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib222
  article-title: Convection-enhanced delivery of camptothecin-loaded polymer nanoparticles for treatment of intracranial tumors
  publication-title: Drug Deliv Transl Res
  doi: 10.1007/s13346-010-0001-3
– volume: 45
  start-page: 127
  issue: 1
  year: 1999
  ident: 10.1016/j.semradonc.2016.06.003_bib120
  article-title: A phase II trial of high-dose bromodeoxyuridine with accelerated fractionation radiotherapy followed by procarbazine, lomustine, and vincristine for glioblastoma multiforme
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/S0360-3016(99)00122-4
– volume: 13
  start-page: 1465
  issue: 11
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib175
  article-title: Mechanistic dissection of PARP1 trapping and the impact on in vivo tolerability and efficacy of PARP inhibitors
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-15-0191-T
– volume: 22
  start-page: 133
  issue: 1
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib227
  article-title: Phase II trial of gefitinib in recurrent glioblastoma
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2004.08.110
– volume: 44
  start-page: 1772
  issue: 5
  year: 1984
  ident: 10.1016/j.semradonc.2016.06.003_bib57
  article-title: DNA cross-linking and cytotoxicity in normal and transformed human cells treated in vitro with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one
  publication-title: Cancer Res
– volume: 27
  start-page: 4733
  issue: 28
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib133
  article-title: Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2008.19.8721
– volume: 366
  start-page: 2455
  issue: 26
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib188
  article-title: Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1200694
– volume: 30
  start-page: 907
  issue: 9
  year: 1980
  ident: 10.1016/j.semradonc.2016.06.003_bib19
  article-title: Assumptions in the radiotherapy of glioblastoma
  publication-title: Neurology
  doi: 10.1212/WNL.30.9.907
– volume: 64
  start-page: 886
  issue: 3
  year: 2006
  ident: 10.1016/j.semradonc.2016.06.003_bib31
  article-title: [F-18]-fluorodeoxyglucose positron emission tomography for targeting radiation dose escalation for patients with glioblastoma multiforme: Clinical outcomes and patterns of failure
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2005.08.013
– volume: 370
  start-page: 699
  issue: 8
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib136
  article-title: A randomized trial of bevacizumab for newly diagnosed glioblastoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1308573
– volume: 15
  start-page: 1100
  issue: 10
  year: 2014
  ident: 10.1016/j.semradonc.2016.06.003_bib151
  article-title: Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071–22072 study): A multicentre, randomised, open-label, phase 3 trial
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(14)70379-1
– volume: 22
  start-page: 1583
  issue: 9
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib205
  article-title: Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2004.06.082
– volume: 45
  start-page: 3008
  issue: 7
  year: 1985
  ident: 10.1016/j.semradonc.2016.06.003_bib55
  article-title: Experimental antitumor activity against murine tumor model systems of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one (mitozolomide), a novel broad-spectrum agent
  publication-title: Cancer Res
– volume: 13
  start-page: 324
  issue: 3
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib109
  article-title: Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/noq157
– volume: 21
  start-page: 29
  issue: 1
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib42
  article-title: ABC transporters and drug efflux at the blood-brain barrier
  publication-title: Rev Neurosci
  doi: 10.1515/REVNEURO.2010.21.1.29
– volume: 1
  start-page: 793
  issue: 9
  year: 1994
  ident: 10.1016/j.semradonc.2016.06.003_bib189
  article-title: Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
  publication-title: Immunity
  doi: 10.1016/S1074-7613(94)80021-9
– volume: 13
  start-page: 1253
  issue: 4
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib131
  article-title: Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-06-2309
– volume: 6
  start-page: S89
  issue: suppl 1
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib45
  article-title: Personalized medicine for gliomas
  publication-title: Surg Neurol Int
– volume: 225
  start-page: 195
  issue: 1–2
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib101
  article-title: Prognostic significance and mechanism of Treg infiltration in human brain tumors
  publication-title: J Neuroimmunol
  doi: 10.1016/j.jneuroim.2010.05.020
– volume: 3
  start-page: 42
  issue: suppl 4
  year: 2011
  ident: 10.1016/j.semradonc.2016.06.003_bib89
  article-title: Mechanisms of immunomodulation in human glioblastoma
  publication-title: Immunotherapy
  doi: 10.2217/imt.11.39
– volume: 64
  start-page: 7985
  issue: 21
  year: 2004
  ident: 10.1016/j.semradonc.2016.06.003_bib195
  article-title: Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-1525
– volume: 17
  start-page: 2762
  issue: 9
  year: 1999
  ident: 10.1016/j.semradonc.2016.06.003_bib67
  article-title: Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.1999.17.9.2762
– volume: 17
  start-page: 854
  issue: 6
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib108
  article-title: A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: The ACT III study
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nou348
– volume: 8
  start-page: 2243
  issue: 8
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib180
  article-title: Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-09-0201
– volume: 303
  start-page: 1323
  issue: 23
  year: 1980
  ident: 10.1016/j.semradonc.2016.06.003_bib17
  article-title: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery
  publication-title: N Engl J Med
  doi: 10.1056/NEJM198012043032303
– volume: 37
  start-page: 491
  issue: 3
  year: 1997
  ident: 10.1016/j.semradonc.2016.06.003_bib37
  article-title: Pion radiation for high grade astrocytoma: Results of a randomized study
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/S0360-3016(96)00542-1
– volume: 352
  start-page: 987
  issue: 10
  year: 2005
  ident: 10.1016/j.semradonc.2016.06.003_bib40
  article-title: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa043330
– volume: 40
  start-page: 57
  issue: 1
  year: 1998
  ident: 10.1016/j.semradonc.2016.06.003_bib48
  article-title: Radiation therapy and hydroxyurea followed by the combination of 6-thioguanine and BCNU for the treatment of primary malignant brain tumors
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/S0360-3016(97)00566-X
– volume: 15
  start-page: 1257
  issue: 9
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib140
  article-title: Bevacizumab as a treatment for radiation necrosis of brain metastases post stereotactic radiosurgery
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/not085
– volume: 133
  start-page: 334
  issue: 3
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib167
  article-title: Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2011.11.010
– volume: 91
  start-page: 961
  issue: 5
  year: 2015
  ident: 10.1016/j.semradonc.2016.06.003_bib123
  article-title: Phase 1/2 trials of Temozolomide, Motexafin Gadolinium, and 60-Gy fractionated radiation for newly diagnosed supratentorial glioblastoma multiforme: Final results of RTOG 0513
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2014.12.050
– volume: 10
  start-page: 196
  issue: 3
  year: 2012
  ident: 10.1016/j.semradonc.2016.06.003_bib200
  article-title: Spontaneous regression of thoracic metastases while progression of brain metastases after stereotactic radiosurgery and stereotactic body radiotherapy for metastatic renal cell carcinoma: Abscopal effect prevented by the blood-brain barrier?
  publication-title: Clin Genitourin Cancer
  doi: 10.1016/j.clgc.2012.01.004
– volume: 6
  start-page: 63
  issue: 2
  year: 1998
  ident: 10.1016/j.semradonc.2016.06.003_bib116
  article-title: Effect of interstitial and/or systemic delivery of tirapazamine on the radiosensitivity of human glioblastoma multiforme in nude mice
  publication-title: Radiat Oncol Investig
  doi: 10.1002/(SICI)1520-6823(1998)6:2<63::AID-ROI1>3.0.CO;2-F
– volume: 69
  start-page: 801
  issue: 7–8
  year: 1985
  ident: 10.1016/j.semradonc.2016.06.003_bib56
  article-title: Phase I clinical trial of mitozolomide
  publication-title: Cancer Treat Rep
– volume: 104
  start-page: 20902
  issue: 52
  year: 2007
  ident: 10.1016/j.semradonc.2016.06.003_bib159
  article-title: Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0708541104
– volume: 192
  start-page: 1027
  issue: 7
  year: 2000
  ident: 10.1016/j.semradonc.2016.06.003_bib190
  article-title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
  publication-title: J Exp Med
  doi: 10.1084/jem.192.7.1027
– volume: 76
  start-page: 1537
  issue: 5
  year: 2010
  ident: 10.1016/j.semradonc.2016.06.003_bib144
  article-title: Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2009.12.010
– volume: 94
  start-page: 63
  issue: 1
  year: 2009
  ident: 10.1016/j.semradonc.2016.06.003_bib141
  article-title: Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis
  publication-title: J Neurooncol
  doi: 10.1007/s11060-009-9801-z
– volume: 91
  start-page: 251
  issue: 2
  year: 1999
  ident: 10.1016/j.semradonc.2016.06.003_bib39
  article-title: Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: Results of a phase II prospective trial
  publication-title: J Neurosurg
  doi: 10.3171/jns.1999.91.2.0251
– volume: 368
  start-page: 1509
  issue: 16
  year: 2013
  ident: 10.1016/j.semradonc.2016.06.003_bib187
  article-title: Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1215134
SSID ssj0021729
Score 2.2740848
SecondaryResourceType review_article
Snippet Glioblastoma multiforme (GBM) is an aggressive intracranial tumor characterized by local and distant brain relapse despite aggressive therapy. Current standard...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 281
SubjectTerms Brain Neoplasms - therapy
Combined Modality Therapy - methods
Combined Modality Therapy - trends
Glioblastoma - therapy
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
Medical Oncology
Radiation-Sensitizing Agents - therapeutic use
Radiology
Treatment Outcome
Title Success and Failures of Combined Modalities in Glioblastoma Multiforme: Old Problems and New Directions
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1053429616300182
https://www.clinicalkey.es/playcontent/1-s2.0-S1053429616300182
https://dx.doi.org/10.1016/j.semradonc.2016.06.003
https://www.ncbi.nlm.nih.gov/pubmed/27619250
https://www.proquest.com/docview/1819430450
Volume 26
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fS90wFA7iYPgy3JzbdZtE2Gu9bZomjW8iu143rhuo4FtImmRUrq3Ye1_3t-8kTQvixIGPLT1NOTnny5fm_EDoKwfMM5X2cTqEJ9RSkSjHecKcZa6EBVeHrPfFOZtf0e_XxfUGOhlyYXxYZcT-HtMDWsc706jN6V1dTy-AGeSApizzVaOAJvsMdsq9lR_-GcM8fP8lEU48izzxTz-I8ers7b0ybeNrGWYsFPIcumc9XqGeYqBhJZptozeRQuLj_ivfog3bvEOvF_GQfAf9vliHLohYNQbPVO0DzzvcOgy-D_tga_CiNZ5-wyYZ1w0-XdatBhK9am8VDgm5nsjaI_xzafCvvuFM_zJARBwxEoz1Pbqafbs8mSexn0JS0ZKsElOmigEwllQ4olNWWqFSTpgT1BFbwDwVVLsKvNhoajOlq1IoeEhomzvCVb6LNpu2sR8RZlRVhXEw_9ZR5QpNVMFFZkRpqzzP1QSxQYeyisXGfc-LpRyiym7kqHzplS9DfF0-QekoeNfX23hepBwmSQ7ppACAEtaE50X5v0RtFx25k5nsiEzlI2OboKNR8oG9_t-wB4MtSfBmf0SjGtuuYTggaNQfXqcT9KE3slENxP9xAsa695KhP6Etf9WHI35Gm6v7tf0CtGql94Pf7KNXx2c_5ud_AWBOIyw
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9wwEB7SDbS9lL676UuFXs3asixbuYXQ7abJbgtJIDchWVJw2dgh3v3_GdmyIaQlhV5tj2VGM998skYzAF9zxDxTap-nQ_OIWSYi5fI84s5yV2DA1d2p9-WKL87Zj4vsYgcOh7MwPq0yYH-P6R1ahyuzoM3ZdVXNTpEZpIimPPFVo5AmP4JdX50qm8DuwdHxYjWuuzBGi27TM0sjL3Anzau1VzfKNLUvZ5jwrpbn0EDrfpD6GwntgtH8OTwLLJIc9B_6AnZs_RIeL8M--Su4PN12jRCJqg2Zq8rnnrekcQTdH5fC1pBlYzwDx3UyqWryfV01Gnn0prlSpDuT67ms3Sc_14b86nvO9C9DUCQBJtFeX8P5_NvZ4SIKLRWikhV0E5kiVhyxsWDCUR3zwgoV55Q7wRy1GU5VxrQr0ZGNZjZRuiyEwoeEtqmjuUrfwKRuavsOCGeqzIxDE7COKZdpqrJcJEYUtkzTVE2BDzqUZag37tterOWQWPZbjsqXXvmyS7FLpxCPgtd9yY2HRYphkuRwohQxUGJYeFg0_5OobYMvtzKRLZWxvGdvU9gfJe-Y7L8N-2WwJYkO7XdpVG2bLQ6HHI35_et4Cm97IxvVQP1PJySte_8z9Gd4sjhbnsiTo9Xxe3jq7_TZiR9gsrnZ2o_Isjb6U_CiW0DrJd0
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Success+and+Failures+of+Combined+Modalities+in+Glioblastoma+Multiforme%3A+Old+Problems+and+New+Directions&rft.jtitle=Seminars+in+radiation+oncology&rft.au=Corso%2C+Christopher+D.%2C+MD%2C+PhD&rft.au=Bindra%2C+Ranjit+S.%2C+MD%2C+PhD&rft.date=2016-10-01&rft.issn=1053-4296&rft.volume=26&rft.issue=4&rft.spage=281&rft.epage=298&rft_id=info:doi/10.1016%2Fj.semradonc.2016.06.003&rft.externalDBID=ECK1-s2.0-S1053429616300182&rft.externalDocID=1_s2_0_S1053429616300182
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F10534296%2FS1053429616X00045%2Fcov150h.gif