Assessment of vinyl chloride-induced DNA damage in lymphocytes of plastic industry workers using a single-cell gel electrophoresis technique

• Published in: Toxicology (Amsterdam) Vol. 128; no. 1; pp. 9 - 16
• Main Authors: Awara, Wageh M, El-Nabi, Sobhy H, El-Gohary, Mona
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 26.06.1998; Amsterdam Elsevier Science
• Subjects: Adult; Air - analysis; Biological and medical sciences; Carcinogens - analysis; Carcinogens - toxicity; Chemical and industrial products toxicology. Toxic occupational diseases; Chemical Industry; Comet assay; DNA damage; DNA Damage - drug effects; Electrophoresis, Polyacrylamide Gel; Humans; Lymphocytes - drug effects; Male; Medical sciences; Middle Aged; Occupational Exposure - adverse effects; Occupational Exposure - analysis; Plastics; Plastics workers; Single-cell gel electrophoresis; Time Factors; Toxicology; Various organic compounds; Vinyl Chloride - analysis; Vinyl Chloride - toxicity; Vinyl chloride monomer; CEO, chlorethylene oxide; Single-cell gel electrophoresis; Plastics workers; SCE, sister chromatid exchange; DNA damage; TLV, threshold limit value; Vinyl chloride monomer; VCM, vinyl chloride monomer; Comet assay; SCGE, single-cell gel electrophoresis; CAA, chloroacetaldehyde; Human; Mutagenicity testing; Toxicity; DNA; Ethylene(chloro); Plastics industry; Occupational exposure; Lymphocyte; Occupational medicine

DNA damage and the formation of stable carcinogen–DNA adducts are considered critical events in the initiation of the carcinogenic process. This study was carried out to assess whether exposure of plastics industry workers to the vinyl chloride monomer (VCM) for different periods of time would cause...