Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 295; no. 2; pp. R681 - R689
• Main Authors: McAllister, Sandra E, Ashrafpour, Homa, Cahoon, Neil, Huang, Ning, Moses, Michael A, Neligan, Peter C, Forrest, Christopher R, Lipa, Joan E, Pang, Cho Y
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2008
• Subjects: Adenosine Triphosphate - metabolism; Animals; Atractyloside - administration & dosage; Calcium; Calcium - metabolism; Cyclosporine - administration & dosage; Disease Models, Animal; Hogs; Infarction - metabolism; Infarction - pathology; Infarction - prevention & control; Injections, Intravenous; Mitochondria, Muscle - drug effects; Mitochondria, Muscle - metabolism; Mitochondrial Membrane Transport Proteins - drug effects; Mitochondrial Membrane Transport Proteins - metabolism; Muscle, Skeletal - blood supply; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Musculoskeletal system; Peroxidase - metabolism; Protein synthesis; Proteins; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Reperfusion Injury - prevention & control; Swine; Time Factors; Tissues

1 Research Institute, The Hospital for Sick Children and Departments of 2 Surgery and 3 Physiology, University of Toronto, Toronto, Ontario, Canada; and 4 Department of Surgery, University of Washington, Seattle, Washington Submitted 20 March 2008 ; accepted in final form 26 May 2008 We tested our h...