Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans

• Published in: British journal of nutrition Vol. 116; no. 11; pp. 1901 - 1911
• Main Authors: Hu, Ying, McIntosh, Graeme H., Le Leu, Richard K., Somashekar, Roshini, Meng, Xing Q., Gopalsamy, Geetha, Bambaca, Libby, McKinnon, Ross A., Young, Graeme P.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.12.2016
• Subjects: Aged; Anticarcinogenic Agents - therapeutic use; Bertholletia - adverse effects; Bertholletia - chemistry; beta catenin; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - metabolism; biopsy; blood; Brazil nuts; C-reactive protein; Camellia sinensis - chemistry; carcinogenesis; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Colorectal Neoplasms - prevention & control; Dietary supplements; Dietary Supplements - adverse effects; DNA; Extraction processes; Feasibility Studies; Female; Food Handling; Functional Food - adverse effects; genes; Green tea; Health risks; histones; Human and Clinical Nutrition; Humans; inflammation; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Male; messenger RNA; Methylation; methyltransferases; Middle Aged; nutrition risk assessment; Nuts; Nuts - adverse effects; Nuts - chemistry; Plant Extracts - adverse effects; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Plant Leaves - chemistry; protein content; Rectum - metabolism; Rectum - pathology; Risk; Selenium - administration & dosage; Selenium - adverse effects; Selenium - blood; Selenium - therapeutic use; selenoproteins; signal transduction; South Australia - epidemiology; Tea; transcription factor NF-kappa B; volunteers; Biomarkers; Colorectal cancer risk; Green tea extract; Brazil nuts; Selenium; DNMT DNA methyltransferase; CRC colorectal cancer; Ac-H3 acetylated histone H3; EGCG (-)-epigallocatechin-3-gallate; SePP selenoprotein P; GTE green tea extract

Se and green tea have been shown in epidemiological, observational and preclinical studies to be inversely related to the risk of developing colorectal cancer (CRC). However, there are limited studies to evaluate their regulatory effects on genes/proteins that relate to CRC oncogenesis in human subj...