Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans - Hu, Ying; McIntosh, Graeme H.; Le Leu, Richard K.; Somashekar, Roshini; Meng, Xing Q.; Gopalsamy, Geetha; Bambaca, Libby; McKinnon, Ross A.; Young, Graeme P. (British journal of nutrition, 2016)
Keywords: Aged; Anticarcinogenic Agents - therapeutic use; Bertholletia - adverse effects; Bertholletia - chemistry; beta catenin; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - metabolism; biopsy; blood; Brazil nuts; C-reactive protein; Camellia sinensis - chemistry; carcinogenesis; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Colorectal Neoplasms - prevention & control; Dietary supplements; Dietary Supplements - adverse effects; DNA; Extraction processes; Feasibility Studies; Female; Food Handling; Functional Food - adverse effects; genes; Green tea; Health risks; histones; Human and Clinical Nutrition; Humans; inflammation; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Male; messenger RNA; Methylation; methyltransferases; Middle Aged; nutrition risk assessment; Nuts; Nuts - adverse effects; Nuts - chemistry; Plant Extracts - adverse effects; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Plant Leaves - chemistry; protein content; Rectum - metabolism; Rectum - pathology; Risk; Selenium - administration & dosage; Selenium - adverse effects; Selenium - blood; Selenium - therapeutic use; selenoproteins; signal transduction; South Australia - epidemiology; Tea; transcription factor NF-kappa B; volunteers; Biomarkers; Colorectal cancer risk; Green tea extract; Brazil nuts; Selenium; DNMT DNA methyltransferase; CRC colorectal cancer; Ac-H3 acetylated histone H3; EGCG (-)-epigallocatechin-3-gallate; SePP selenoprotein P; GTE green tea extract