Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis

• Published in: Mutation research Vol. 823; pp. 28 - 44
• Main Authors: Rahman, Luna, Jacobsen, Nicklas Raun, Aziz, Syed Abdul, Wu, Dongmei, Williams, Andrew, Yauk, Carole L., White, Paul, Wallin, Hakan, Vogel, Ulla, Halappanavar, Sabina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: Animals; Bronchoalveolar Lavage Fluid - cytology; Carcinogenesis - drug effects; Cell Proliferation - drug effects; Chemical Phenomena; Comet Assay; DNA Damage - drug effects; Endpoint Determination; Female; Lung - cytology; Lung - drug effects; Mice; Nanotubes, Carbon - toxicity; Pneumonia - chemically induced; Pneumonia - pathology; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - pathology; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism

•The lung responses of straight and rigid MWCNTs, NM-401 and Mitsui-7 were tested.•Genotoxic, inflammatory, fibrotic and gene expression responses were investigated.•Both MWCNTs induce low levels of DNA breaks, p53 activation, but are not mutagenic.•Both MWCNTs perturb expression of inflammatory, fi...