Cell Cycle Reactivation, at the Start of Neurodegeneration, Induced by Forskolin and Aniline in Differentiated Neuroblastoma Cells

• Published in: International journal of molecular sciences Vol. 24; no. 18; p. 14373
• Main Authors: Sturiale, Valentina, Bruno, Francesca, Brancato, Desiree, D’Amico, Agata Grazia, Maugeri, Grazia, D’Agata, Velia, Saccone, Salvatore, Federico, Concetta
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Advertising executives; Alzheimer's disease; Aniline; Cell culture; Cell cycle; Cell death; Cell division; Cyclin-dependent kinases; cyclins; Hypotheses; Kinases; Laboratory animals; Morphology; Neuroblastoma; Neurodegeneration; Neurons; nuclear tau; nucleolus; Parkinson's disease; Phosphorylation; Proteins; Scientific equipment and supplies industry; SH-SY5Y cell line; Tretinoin; United States; Germany; California

A characteristic hallmark of Alzheimer’s disease (AD) is the intracellular accumulation of hyperphosphorylated tau protein, a phenomenon that appears to have associations with oxidative stress, double-stranded DNA breakage, and the de-condensation of heterochromatin. Re-entry into the cell division...