R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation

• Published in: Nucleic acids research Vol. 50; no. D1; pp. D303 - D315
• Main Authors: Lin, Ruoyao, Zhong, Xiaoming, Zhou, Yongli, Geng, Huichao, Hu, Qingxi, Huang, Zhihao, Hu, Jun, Fu, Xiang-Dong, Chen, Liang, Chen, Jia-Yu
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 07.01.2022
• Subjects: Cell Line, Tumor; Chromosome Mapping; Computational Biology - methods; Database Issue; Databases, Nucleic Acid; Datasets as Topic; DNA - chemistry; DNA - genetics; DNA - metabolism; Gene Regulatory Networks; Genome; Genomic Instability; HEK293 Cells; Humans; Internet; Molecular Sequence Annotation; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Nervous System Diseases - genetics; Nervous System Diseases - metabolism; Nervous System Diseases - pathology; Protein Interaction Mapping - methods; R-Loop Structures; RNA - chemistry; RNA - genetics; RNA - metabolism; Software; Transcription, Genetic

Abstract R-loops play versatile roles in many physiological and pathological processes, and are of great interest to scientists in multiple fields. However, controversy about their genomic localization and incomplete understanding of their regulatory network raise great challenges for R-loop researc...