Orally administered simvastatin partially preserves lumbar vertebral bone mass but not integrity of intervertebral discs in ovariectomized rats

• Published in: Experimental and therapeutic medicine Vol. 13; no. 3; pp. 877 - 884
• Main Authors: Tian, Fa-Ming, Li, Shu-Yang, Yang, Kai, Luo, Yang, Dai, Mu-Wei, Liu, Guang-Yuan, Song, Hui-Ping, Zhang, Liu
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2017; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Analysis; Back pain; Biomechanics; Bone density; Bone diseases; Care and treatment; Dosage and administration; Osteoporosis; Rodents; Simvastatin; Standard deviation; Studies; Tomography; Vertebrae; Yield stress; United States > US; China; simvastatin; bone mineral density; intervertebral disc

The present study aimed to investigate the effect of orally administered simvastatin on lumbar vertebral bone mass and intervertebral disc (IVD) degeneration in ovariectomized (OVX) rats. A total of 30 female Sprague-Dawley (SD) rats were subjected to either bilateral ovariectomy (n=20) or sham surg...