Effects of Insufficient Sleep on Pituitary–Adrenocortical Response to CRH Stimulation in Healthy Men

• Published in: Sleep (New York, N.Y.) Vol. 40; no. 6
• Main Authors: Guyon, Aurore, Morselli, Lisa L., Balbo, Marcella L., Tasali, Esra, Leproult, Rachel, L’Hermite-Balériaux, Mireille, Van Cauter, Eve, Spiegel, Karine
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2017
• Subjects: Adolescent; Adrenocorticotropic Hormone - blood; Adult; Animals; Corticotropin-Releasing Hormone - pharmacology; Cross-Over Studies; Female; Healthy Volunteers; Humans; Hydrocortisone - blood; Male; Original; Pituitary-Adrenal System - drug effects; Pituitary-Adrenal System - physiopathology; Random Allocation; Sheep; Sleep - drug effects; Sleep - physiology; Sleep Deprivation - physiopathology; Stress, Psychological - blood; Stress, Psychological - diagnosis; Young Adult; sleep; ACTH; CRH; cortisol; stress; HPA axis

Abstract Study Objectives: Severe sleep restriction results in elevated evening cortisol levels. We examined whether this relative hypercortisolism is associated with alterations in the pituitary–adrenocortical response to evening corticotropin-releasing hormone (CRH) stimulation. Methods: Eleven su...