Acute LSD effects on response inhibition neural networks

• Published in: Psychological medicine Vol. 48; no. 9; pp. 1464 - 1473
• Main Authors: Schmidt, A., Müller, F., Lenz, C., Dolder, P. C., Schmid, Y., Zanchi, D., Lang, U. E., Liechti, M. E., Borgwardt, S.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.07.2018
• Subjects: Adult; Altered states; Alzheimer's disease; Behavior disorders; Brain; Brain Mapping; Brain research; Cerebellum; Cognition & reasoning; Cognitive ability; Cognitive impairment; Consciousness; Cortex; Cortex (cingulate); Cross-Over Studies; Double-Blind Method; Family medical history; Female; Frontal gyrus; Functional magnetic resonance imaging; Go/no-go discrimination learning; Hallucinations; Hallucinations - chemically induced; Hallucinations - physiopathology; Hallucinogens - administration & dosage; Health care; Healthy Volunteers; Hippocampus; Hippocampus - drug effects; Hippocampus - physiopathology; Humans; Induced; LSD; Lysergic acid diethylamide; Lysergic Acid Diethylamide - pharmacology; Lysergide; Magnetic Resonance Imaging; Male; Mental disorders; Mental task performance; Middle Aged; Narcotics; Neural networks; Neuroimaging; Neuropsychological Tests; Neurosciences; NMR; Nuclear magnetic resonance; Original Articles; Parahippocampal gyrus; Postcentral gyrus; Prefrontal cortex; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiopathology; Psychiatry; Psychosis; Questionnaires; Response inhibition; Schizophrenia; Serotonin; Serotonin receptors; Serotonin S2 receptors; Switzerland; Temporal gyrus; Temporal lobe; Visual cortex; Visual hallucinations; Visual imagery; Visual perception; Visual system; Switzerland; fMRI; visual hallucinations; LSD; Cognitive control

Recent evidence shows that the serotonin 2A receptor (5-hydroxytryptamine2A receptor, 5-HT2AR) is critically involved in the formation of visual hallucinations and cognitive impairments in lysergic acid diethylamide (LSD)-induced states and neuropsychiatric diseases. However, the interaction between...