ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma

• Published in: Molecular medicine reports Vol. 17; no. 5; pp. 6293 - 6300
• Main Authors: Huang, Chuanjun, Zhang, Zewen, Wang, Liuxin, Liu, Ju, Gong, Xiaodan, Zhang, Caiqing
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.05.2018; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Airway obstruction; Asthma; Collagen; Cytokines; Extracellular matrix; Fibroblasts; Growth factors; Immunoregulation; Inflammation; Interleukin 4; Kinases; Lymphocytes T; Muscle contraction; Myosin; Myosin-light-chain kinase; Ovalbumin; Pathogenesis; Respiratory function; Respiratory tract; Respiratory tract diseases; Risk factors; Smooth muscle; Beijing China; United States > US; China; Germany

Previous studies have indicated that smooth muscle myosin light chain kinase (MLCK) has a prominent role in the regulation of smooth muscle contraction, which tends to be upregulated in asthma. In recent years, numerous studies have reported that MLCK is intimately connected with the immunoregulator...