HLA Class I Expression Is Associated with DNA Damage and Immune Cell Infiltration into Dysplastic and Neoplastic Lesions in Ulcerative Colitis

• Published in: International journal of molecular sciences Vol. 24; no. 17; p. 13648
• Main Authors: Okami, Haruka, Ozawa, Naoya, Sohda, Makoto, Yokobori, Takehiko, Osone, Katsuya, Erkhem-Ochir, Bilguun, Dorjkhorloo, Gendensuren, Shiraishi, Takuya, Okada, Takuhisa, Sano, Akihiko, Sakai, Makoto, Miyazaki, Tatsuya, Ogawa, Hiroomi, Yao, Takashi, Oike, Takahiro, Sato, Hiro, Shirabe, Ken, Shibata, Atsushi, Saeki, Hiroshi
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Anti-inflammatory agents; Antigen presentation; Antimitotic agents; Antineoplastic agents; Cancer; Cancer therapies; Cells; colitic cancer; Colon; Colorectal cancer; Cytotoxicity; DNA; DNA damage; Genetic aspects; Genetic research; Histocompatibility antigens; HLA histocompatibility antigens; human leukocyte antigen; immune cells; Immunohistochemistry; Inflammation; Inflammatory bowel disease; Lymphocytes; Medical colleges; Medical research; Proteins; T cells; Tumors; Ulcerative colitis; Japan

Human leukocyte antigen class I (HLA-I) is considered a genetic pathogen for ulcerative colitis (UC). This study aimed to investigate the significance of DNA damage and HLA-I expression in infiltrating immune cells and immune checkpoint protein PD-L1 expression in dysplasia/colitic cancer (CC) and s...