Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational Study

• Published in: Microorganisms (Basel) Vol. 9; no. 9; p. 1896
• Main Authors: Franceschini, Erica, Cozzi-Lepri, Alessandro, Santoro, Antonella, Bacca, Erica, Lancellotti, Guido, Menozzi, Marianna, Gennari, William, Meschiari, Marianna, Bedini, Andrea, Orlando, Gabriella, Puzzolante, Cinzia, Digaetano, Margherita, Milic, Jovana, Codeluppi, Mauro, Pecorari, Monica, Carli, Federica, Cuomo, Gianluca, Alfano, Gaetano, Corradi, Luca, Tonelli, Roberto, De Maria, Nicola, Busani, Stefano, Biagioni, Emanuela, Coloretti, Irene, Guaraldi, Giovanni, Sarti, Mario, Luppi, Mario, Clini, Enrico, Girardis, Massimo, Gyssens, Inge, Mussini, Cristina
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 07.09.2021; MDPI
• Subjects: Coronaviruses; COVID-19; Cytomegalovirus; Encephalitis; Gingivostomatitis; Hepatitis; Herpes labialis; Herpes simplex; Herpes viruses; Herpesviridae; Immunosuppressive agents; Infections; Mechanical ventilation; Observational studies; Patients; Pneumonia; re-activation; Regression analysis; SARS-Cov-2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Steroid hormones; Steroids; tocilizumab; Viral diseases; Viremia; Viruses

Background: Herpes simplex 1 co-infections in patients with COVID-19 are considered relatively uncommon; some reports on re-activations in patients in intensive-care units were published. The aim of the study was to analyze herpetic re-activations and their clinical manifestations in hospitalized CO...