Gadolinium-Based Nanoparticles Can Overcome the Radioresistance of Head and Neck Squamous Cell Carcinoma Through the Induction of Autophagy

• Published in: Journal of biomedical nanotechnology Vol. 16; no. 1; p. 111
• Main Authors: Simonet, S, Rodriguez-Lafrasse, C, Beal, D, Gerbaud, S, Malesys, C, Tillement, O, Lux, F, Fayyad-Kazan, H, Rachidi, W, Ardail, D
• Format: Journal Article
• Language: English
• Published: United States 01.01.2020
• Subjects: Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Gadolinium; Head and Neck Neoplasms; Humans; Metal Nanoparticles; Squamous Cell Carcinoma of Head and Neck

Radiation therapy is a mainstay in the therapeutic management of Head and Neck Squamous Cell Carcinoma (HNSCC). Despite significant progress in this field, radioresistance still accounts for most treatment failures. Gadolinium-based nanoparticles (GBNs) have shown great promises as radiosensitizers...