Wheat bran extract alters colonic fermentation and microbial composition, but does not affect faecal water toxicity: a randomised controlled trial in healthy subjects

• Published in: British journal of nutrition Vol. 113; no. 2; pp. 225 - 238
• Main Authors: Windey, Karen, De Preter, Vicky, Huys, Geert, Broekaert, Willem F., Delcour, Jan A., Louat, Thierry, Herman, Jean, Verbeke, Kristin
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.01.2015
• Subjects: Adult; ammonia; Anticarcinogenic Agents - adverse effects; Anticarcinogenic Agents - therapeutic use; Belgium - epidemiology; Bifidobacterium adolescentis; Bioassays; Biomarkers; Biomarkers - analysis; cell viability; Colon; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - prevention & control; colorimetry; comet assay; Cross-Over Studies; Cytotoxicity; denaturing gradient gel electrophoresis; Dietary Fiber - analysis; Double-Blind Method; Dysbiosis - metabolism; Dysbiosis - microbiology; Dysbiosis - prevention & control; excretion; Feces - chemistry; Feces - microbiology; Female; Fermentation; Gastrointestinal Agents - adverse effects; Gastrointestinal Agents - therapeutic use; Gastrointestinal Microbiome; Genotoxicity; Human and Clinical Nutrition; Humans; lactose; Male; maltodextrins; metabolomics; microbial activity; Microbiology; microorganisms; nitrogen; Nutrition; nutrition risk assessment; placebos; Plant Extracts - adverse effects; Plant Extracts - therapeutic use; prebiotics; Prebiotics - adverse effects; randomized clinical trials; rats; Risk; Risk factors; Risk reduction; Seeds - chemistry; stable isotopes; Triticum - chemistry; Triticum aestivum; viability assays; volunteers; Water pollution; Wheat; Wheat bran; Young Adult; Faecal water toxicity; Arabinoxylan-oligosaccharides; Colonic fermentation; Gut microbial composition

Wheat bran extract (WBE), containing arabinoxylan-oligosaccharides that are potential prebiotic substrates, has been shown to modify bacterial colonic fermentation in human subjects and to beneficially affect the development of colorectal cancer (CRC) in rats. However, it is unclear whether these ch...